Copyright 2003. American Cavy Breeders Association. All rights reserved
ANTIBIOTICS What I Use
I will discuss the commonly used antibiotics for
kidneys and can potentially cause fatal antibiotic-
cavies and describe several medical situations where I
induced diarrhea in cavies. I personally use Amikacin
would, or have, used them. I must point out that each
because its side effects are reported to be less severe
individual medical case is unique and treatment is
than Gentocin. only use this drug when I suspect an
based on the situation in that case. I don't routinely
infection with Pseudomonas, as with cases of
use antibiotics for every cough, sniffle or runny nose.
seminal vesiculitis I've seen, and in abscesses with
I very rarely use antibiotics in pregnancy toxemia
culture results indicating such infection. I feel these
cases or for small abscesses, usually only for larger
drugs are often more harmful than helpful in other
cervical abscesses where they may impair the
situations. The dosage is lmg/#BW once daily (and it
throat/trachea, or when transmission to other animals
Tetracycline/Oxytetracyline (Terramycin): This class
of drugs is not very effective against most infections
but may have some effect on respiratory problems
Bactrim, Tribrissen): My first choice in almost all
caused by certain microorganisms. These drugs have
cases. It is a very good drug for respiratory and
been indicated in causing some antibiotic-induced
urinary tracts, as well as the skin. I also use it for
diarrhea. I have recommended oxytetracycline
diarrhea cases where the animal is obviously feeding
powder (Terramycin) as a herd treatment for
poorly. The oral suspension is usually concentrated at
nonspecific upper respiratory and eye infections
48 mg/ml, dosage is .3 -.5ml per pound (#)
affecting a large percentage of the animals, or when
bodyweight (BW) per day. It is usually available at
infection-prone animals are going to be stressed. Oral
suspension dose is 25mg/#BW divided into 4 equaldoses. Terramycin powder is mixed at Itbl/gallon of
Baytril (Enrofloxacin): My second choice when I
water. Watch for refusal of the water. Sugar can be
have a situation resistant to SMZ-TMP or can only
added to the solution to improve palatability.
use the injectable form. It has a wider spectrum thanSMZ-TMP and comes in tablet form as well. The
Tresaderm: This is an ear medication for dogs and
dosage is the same for dogs and cats, Iml/20#BW,
cats that I have used for ear infections in cavies. This
injected once daily, or tablets as noted for tablet size
combination has an antibiotic, an antifungal, an anti-
(No. 5 is per 5#BW). Tablets can be dissolved in
inflammatory steroid in it, and may be used with
water or other liquid and given orally twice daily.
caution is pregnant sows. I usually don't see too much
This should not be used in growing animals.
exudate from the ears, just a head tilt. I use 1 drop ineach ear twice daily for 3-5 days, or until the tilt
The new dosage for Baytril is 5-10mg/kg bodyweight
(or 2-4 mg/#). This drug is not effective againstStreptococcus sp. of bacteria.*
When to use antibiotics is often a judgement call. A cough, sneeze, rattle or wet nose doesn't get me
Chloramphenicol (Chloromycetin Palmitate): A very
excited unless the animal is slightly lethargic,
effective antibiotic, especially for respiratory
tapering off feed and/or drinking little. Soft stools
infections. The oral suspension has limited
aren't exciting unless the animal is gassy, crampy or
availability, but the tablet form can be obtained at
very depressed. Crying during urination doesn't
most veterinary offices. This drug has been shown to
impress me unless it reoccurs or it is accompanied by
cause aplastic anemia in humans with prolonged
lots of straining. I will sometimes treat for 1-2 days
exposure. Dosage is 25mg/#BW 3 times daily.
the cavy whose congested rattle has gone on for 34days. A very sick pig with possible pneumonia will
Gentocin/Amikacin: These two drugs are in the same
stay on SMZ-TMP if it is swallowing well, but gets
class of antibiotics and are what I consider to be the
switched to baytril if it is not Pneumonia can often
"big guns". They are extremely hazardous to the
Copyright 2003. American Cavy Breeders Association. All rights reserved
have few respiratory signs, just showing depression
will often leave them with the family group as long as
there are no bullies around. The fewer changes intheir normal routine, the better these animals will
I have often had baby pigs up to 6 weeks of age that
develop a gassy, crampy gut and diarrhea. If I cancatch them at the depressed, no diarrhea stage I'II
Some of the antibiotics that should NEVER be used
start them on simethicone drops (baby gas drops) and
are streptomcin, penicillin, amoxicillin, clindamycin,
SMZ-TMP. Once they have diarrhea it is hard to turn
cephalexin, lincomycin, erythromycin or any of their
them around - they become toxic very quickly. I often
treat the littermates on a once daily basis forprevention.
The action of these drugs affects the normal flora ofthe gut, causing a fatal and irreversible diarrhea.
If an animal is depressed, not eating/drinking and not
There is some thought that a few of these drugs cause
pregnant, I will try force-feeding first to see if it
a fatal allergic reaction. Any use of these drugs is
responds. If no improvement after 24 hours I often
always a bad choice, even when the alternative is no
start SMZ-TMP, hoping for a responsive infection. I
therapy at all. They always make the situation worse.
keep sick pigs warm and quiet, sometimes on aheating pad set on low. I prefer to avoid any
I hope I've answered some of your questions and have
injections if possible, using oral antibiotics and force-
provided a reference for future treatments. Feel free
feeding baby food and yogurt to supplement nutrition
to call me with your individual cases, advice is
and fluids. This is one of the few times I'II use
always free. Your experiences provide a greater base
iceberg lettuce, specifically as a water source. I try to
of knowledge for me to rely upon in answering the
handle them as little as possible to decrease stress. I
questions posed by others. If we all work together we
don't like to totally isolate them, but keep them within
hearing distance of other cavies - they seem to domuch better if they don't feel alone. With sick babies I
Except as specified below, no part of this publication may be reproduced in any form or by any means, including electronically, or transmitted byany means without permission in writing from the American Cavy Breeders Association (ACBA). Copying: Single copies of individual articles maybe made for private use or research providing copies bear the ACBA copyright notice. Authorization does not extend to copies made or distributedfor profit, commercial advantage, promotional purposes, to electronic storage or distribution, or to republication in any form. In all such cases,specific written permission from ACBA must be obtained. Permission for Other Use: Permission is granted for brief quotes with the customaryacknowledgment of the source. To reprint a figure, table or other excerpt requires the consent of the ACBA. For permission contact: LenoreGergen (ACBA Secretary), 16540 Hogan Avenue, Hastings, MN 55033. Opinions of individual authors are their own and do not necessarily reflectthose of the ACBA, its board or officers.
Combination Therapy of Zonisamide and Bupropion for Weight Reduction in Obese Women: A Preliminary, Randomized, Open-Label Study Kishore M. Gadde, M.D.; Gretchen M. Yonish, R.D.; Mariko S. Foust, R.D.; and H. Ryan Wagner II, Ph.D. Received July 15, 2006; accepted Nov. 27, 2006. From the Obesity Clinical Trials Program, Duke University Medical Center, Durham, N.C. There was no e
Attenuation of SSRI-induced increases in extracellular brain 5-HT by benzodiazepines Chapter 8 Attenuation of SSRI-induced increases in extracellular brain 5-HT by benzodiazepines. Abstract Enhanced serotonergic neurotransmission is generally thought to be the neurochemical basisof the antidepressant effects of Selective Serotonin Reuptake Inhibitors (SSRIs). The anxiolytic benzodiaz