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Neurodyn Inc. Acquires MemogainÂ® For Dementia in Alzheimerâ€™s Disease
Neurodyn Inc. announced today that it has acquired from Galantos Pharma GmbH, Mainz, Germany
(galantos.com) all assets related to their Alzheimerâ€™s prescription drug candidate â€“ MemogainÂ®.
MemogainÂ® has completed an extensive preclinical development program and is ready to proceed
into Phase 1 clinical trials in late 2013. The terms of the acquisition were not disclosed.
â€œWe are very pleased to complete this acquisition. MemogainÂ® is a significant improvement
over existing Alzheimerâ€™s drugs, and is staged for immediate entry into clinical trials. It has the
potential to follow a fast-track regulatory pathway in both the US and Europe,â€• said Kenneth
MemogainÂ® is a patented improvement on the generic drug, galantamine, (Nivalin, Razadyne,
Razadyne ER, Reminyl, Lycoremine). Galantamine, a plant-derived compound, is widely prescribed to
enhance cognition for the treatment of mild to moderate Alzheimer's disease, but has a limited
capacity for brain penetration and significant side effects that limit its effectiveness. MemogainÂ® was
developed to have a much higher bioavailability in the brain, without the negative gastro-intestinal
side effects that limit patient acceptance.
Neurodyn will also investigate the potential for MemogainÂ® to decrease the amyloid plaque
burden associated with Alzheimerâ€™s disease and to induce new cell growth in regions of the brain
Sales of galantamine are currently in excess of $500 million per year. The worldwide
Alzheimerâ€™s drug market is currently estimated to exceed $4.2 billion and is growing rapidly due to the
aging demographic. Current drugs on the market have significant side effects which limit their
effectiveness and reduce their usefulness.
The revenue potential for MemogainÂ® could extend beyond the current galantamine market share
due to the urgent medical need for Alzheimerâ€™s drugs that have increased efficacy and decreased
side effects compared to the current anti-dementia drugs.
Neurodyn Inc. (www.neurodyn.ca) is a Canadian biotechnology company focused on identifying,
validating and developing natural bioactives into both prescription drugs and natural products for the
early treatment of neurological diseases. Neurodyn examines historically-proven natural products to
discover key bioactives which can either be reformulated or repurposed to provide more effective
Neurodynâ€™s lead technologies include ND1208, a neuroprotectant for use in early stage
Parkinsonâ€™s disease, which is incorporated into both a nutrition supplement (in market) and a
US-FDA Medical Food product (under development), Progranulin (ND602), a novel therapeutic
demonstrating pre-clinical efficacy in ALS, Parkinsonâ€™s disease, Alzheimer's disease and Spinal
Muscular Atrophy, and a natural product derived Nerve Pain Treatment (NQ1123), which is being
developed as a prescription drug for a topical nerve pain condition.
Galantos Pharma GmbH (www.galantos.com) is a German biotechnology company founded in
2005 by Professors Alfred Maelicke (Mainz) and Ulrich Jordis (Vienna). Both have been intimately
involved in the original development of galantamine, and in bringing the drug to market. Realizing the
limited brain penetration of the plant-derived drug galantamine, they set out to develop a
pro-galantamine with much higher bioavailability in the brain and without compliance-compromising
gastro-intestinal side effects. In addition, their new drug candidate MemogainÂ® has the potential of both
neuroprotection and disease-modification. Prof. Maelicke will continue with Neurodyn as Managing
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