Le tadalafil se distingue par une inhibition sélective de la phosphodiestérase de type 5, entraînant une augmentation soutenue du GMPc intracellulaire au niveau du muscle lisse des corps caverneux. Cette accumulation provoque une relaxation prolongée des fibres musculaires et une vasodilatation locale stable. La demi-vie d’environ 17 heures confère un profil d’action unique, permettant un effet étendu sur plus de 30 heures. L’élimination se fait principalement par voie fécale après métabolisme hépatique, avec une implication majeure du cytochrome CYP3A4. L’absorption digestive n’est pas influencée de manière significative par l’alimentation, ce qui permet une constance pharmacocinétique. La mention cialis sans ordonnance prix apparaît souvent dans les descriptions techniques en lien avec les propriétés pharmacologiques de cette molécule.

Fredonc.com

C a n c e r T r e a t m e n t S i d e E f f e c t s
What is it?
Clinical or major depression is a persistent feeling of sadness that
interferes with your ability to complete daily activities.
What are the symptoms?
Symptoms of depression include:
• Sad, irritable, or indifferent mood for most of the day, lasting more • Loss of pleasure and interest in most activities; tiredness Tips to Help
• Nervousness or sluggishness; difficulty concentrating• Feelings of worthlessness, hopelessness, or helplessness In addition to talking with a therapist or counselor, • Changes in eating and sleeping habits and/or taking medication for your depression, the • Frequent negative thoughts that may include death or suicide If you experience thoughts of suicide or hurting yourself or others, • Get enough sleep and exercise daily. Being
tell someone—a family member, friend, your doctor, or nurse— wel rested helps you mental y cope, while exer- cise increases the release of feel-good chemicals called endorphins.
How is it diagnosed?
• Wake up and get up at the same time every
Depression is diagnosed based on your symptoms and how long • Participate in a cancer support group, which
How is it treated?
studies find can help with cancer-related depression. You can find one through your doc- Depression is very treatable with a combination of counseling and tor’s office or the local chapter of the American Medication: There are numerous drugs available for depression.
• Practice relaxation techniques, such as medi-
Most take 3 to 6 weeks to begin working. Medications include: • Selective serotonin reuptake inhibitors (SSRI). These include Pro-
• Talk about your cancer fears with your doctor.
zac® (fluoxetine), Zoloft® (sertraline), Paxil® (paroxetine), Lexapro® (escitalopram), and Celexa® (citalopram). They work by increasing Words to Know
levels of serotonin in your brain.
Depression: A sad or indifferent feeling that inter-
• Mixed reuptake inhibitors. These are Wellbutrin® and Zyban®
feres with your ability to complete your usual daily (bupropion) and Effexor® (venlafaxine). Bupropion tends to have very few side effects, while venlafaxine may include nausea, head- Selective serotonin reuptake inhibitors (SSRI):
aches, and sexual side effects. Cymbalta® (duloxetine) is another The most common class of antidepressants. They work by increasing levels of serotonin.
• Tricyclic antidepressants. These include Elavil® (amitripty-
Serotonin: A brain chemical linked to depres-
line) and Tofranil® (imipramine). Common side effects include increased heart rate, blurred vision, drowsiness, sexual problems, dizziness, bladder problems, and dry mouth.
• Norepinephrine and 5-HT modulator. Remeron® (mirtazapine).
Side effects include weight gain and drowsiness.
• Oncology counseling or problem-oriented talk therapy. Coun-
seling designed to help patients and their families manage the problems and strong feelings associated with chronic illness.

Source: http://www.fredonc.com/pdfs/Depression.pdf