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SIGMA-ALDRICH
sigma-aldrich.com
SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006 GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
: Sigma-Aldrich (Shanghai) Trading Co.,Ltd 22A-B Century Ba-Shi Building, 398 Huai Hai Zhong Road 200020 SHANGHAI CHINA
2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
According to Regulation (EC) No1272/2008 Reproductive toxicity (Category 1B) According to European Directive 67/548/EEC as amended. May cause harm to the unborn child. Label elements
May damage fertility or the unborn child. IF exposed or concerned: Get medical advice/attention. Avoid exposure - obtain special instructions before use. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Other hazards - none
Sigma - F4381


3. COMPOSITION/INFORMATION ON INGREDIENTS
5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid 4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid Furosemide
54-31-9 200-203-6
For the full text of the H-Statements mentioned in this Section, see Section 16.
4. FIRST AID MEASURES
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing give artificial respiration Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

5. FIRE-FIGHTING MEASURES
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special protective equipment for fire-fighters
Wear self contained breathing apparatus for fire fighting if necessary.

6. ACCIDENTAL RELEASE MEASURES
Personal precautions
Use personal protective equipment. Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation.
Evacuate personnel to safe areas.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Keep in suitable, closed containers for disposal.

7. HANDLING AND STORAGE
Precautions for safe handling
Avoid formation of dust and aerosols.Avoid exposure - obtain special instructions before use.
Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire
protection.
Conditions for safe storage
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Sigma - F4381

8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Personal protective equipment
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator
type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the
respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and
components tested and approved under appropriate government standards such as NIOSH (US) or CEN
(EU).
Hand protection
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the
standard EN 374 derived from it.

Eye protection
Safety glasses with side-shields conforming to EN166
Skin and body protection
Choose body protection according to the amount and concentration of the dangerous substance at the
work place.
Hygiene measures
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the
product.

9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance
Safety data

10. STABILITY AND REACTIVITY
Chemical stability
Stable under recommended storage conditions.
Conditions to avoid
Avoid moisture. Light.
Materials to avoid
Strong oxidizing agents
Sigma - F4381
Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides, nitrogen oxides (NOx),
Sulphur oxides, Hydrogen chloride gas

11. TOXICOLOGICAL INFORMATION
Acute toxicity
LD50 Oral - rat - 2.600 mg/kg
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity

no data available
Carcinogenicity
This product is or contains a component that is not classifiable as to its carcinogenicity based on its IARC, ACGIH, NTP, or EPA classification. IARC: 3 - Group 3: Not classifiable as to its carcinogenicity to humans (Furosemide) Reproductive toxicity
May cause congenital malformation in the fetus.
Presumed human reproductive toxicant
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation
May be harmful if inhaled. May cause respiratory tract irritation. Ingestion
May be harmful if absorbed through skin. May cause skin irritation. Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly
investigated.
Additional Information
RTECS: CB2625000

12. ECOLOGICAL INFORMATION
Toxicity
Persistence and degradability
no data available
Sigma - F4381
Bioaccumulative potential
no data available
Mobility in soil
no data available
PBT and vPvB assessment
no data available
Other adverse effects
no data available

13. DISPOSAL CONSIDERATIONS
Product
Observe all federal, state, and local environmental regulations. Contact a licensed professional waste
disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

14. TRANSPORT INFORMATION
ADR/RID
Not dangerous goods

IMDG
Not dangerous goods

IATA
Not dangerous goods

15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
16. OTHER INFORMATION
Text of H-code(s) and R-phrase(s) mentioned in Section 3
May damage fertility or the unborn child. Further information
Copyright 2010 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only.
The above information is believed to be correct but does not purport to be all inclusive and shall be used
only as a guide. The information in this document is based on the present state of our knowledge and is
applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee
of the properties of the product. Sigma-Aldrich Co., shall not be held liable for any damage resulting from
handling or from contact with the above product. See reverse side of invoice or packing slip for additional
terms and conditions of sale.
Sigma - F4381

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