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Les effets secondaires du vaccin antivariolique

Les effets secondaires du vaccin antivariolique
Les effets secondaires du
vaccin antivariolique
- Documentation - Les différents effets secondaires des vaccins - Le vaccin antivariolique - Date de mise en ligne : vendredi 4 juin 2010 Description :
Quels sont les effets secondaires du vaccin antivariolique ?
Les effets secondaires du vaccin antivariolique
La vaccination antivariolique est, de loin, la vaccination qui a entraîné les accidents à court terme les plus graves, en particulier l'encéphalite postvaccinale.
Aujourd'hui, elle n'est plus d'actualité, sauf peut-être chez les militaires.
1. L'encéphalite postvaccinale (MIRAVALLE 2003) [
La fréquence varie selon les pays et les estimations : 2. Les allergies (JACQUELIN 1955) [
eczema vaccinatum provenant :
• soit du développement rapide d'une vaccine généralisée consécutive à la vaccination • soit du développement rapide d'une vaccine généralisée consécutive au contact d'un eczémateux avec un poussées d'allergies chez les allergiques recevant une re-vaccination antivariolique :
• poussées d'asthme
• poussée d'urticaire géant
• poussée de psoriasis
3. La survenue de cancers
lymphosarcome (HELMAN 1957) [
tumeurs cutanées à l'endroit des scarifications de vaccination]
mélanomes sur la cicatrice de vaccination antivariolique
possibilité de cancer
Les effets secondaires du vaccin antivariolique
Miravalle, A., & Roos, K. L. (2003). Encephalitis complicating smallpox vaccination. Arch Neurol, 60(7), 925-928.
Abstract: A smallpox vaccination program has been initiated. The vaccine is a live virus that was used in the last century. Postvaccinal encephalitis is a complication of this
vaccine. The clinical presentation, course, neuroimaging findings, and spinal fluid abnormalities are similar to a disorder that physicians are familiar with, acute disseminated encephalomyelitis. This complication can be prevented with the administration of antivaccinia gamma globulin at the time of vaccination. Antivaccinia gamma globulin is not efficacious once this complication occurs. Intravenous methylprednisolone is the recommended therapy, although intravenous immunoglobulin and plasmapheresis should be investigated in the treatment of postvaccinal encephalitis.
Keywords: Animals; Encephalomyelitis, Acute Disseminated/diagnosis/*epidemiology/*etiology/physiopathology/therapy; Humans; Incidence; Smallpox Vaccine/*adverse
Miravalle, A., Biller, J., Schnitzler, E., & Bonwit, A. (2010). Neurological complications following vaccinations. Neurol Res, 32(3), 285-292.
Abstract: OBJECTIVE: To review the most common neurological disorders associated with various vaccines, and offer suggestions aiming at a better understanding if a
causal relationship between the neurological complications and the vaccination is feasible. METHODS: A literature search was conducted in PubMed using combination of the following items: vaccines, vaccination, immunization and neurological complications. Review of reports and publications from the World Health Organizations, US Centers for Disease Control and the Vaccine Adverse Event Reporting System regarding safety and common neurological complications following vaccinations. Especial attention was given to the incidence of complications in various Latin American countries. RESULTS: Neurological complications following vaccination are rare, and in most cases, represent a monophasic neurological event with good clinical recovery. However, serious and fatal complications have been reported. In general, neurological adverse events may not be causally related to the vaccine, and occur at much lower rates than same events following natural disease. DISCUSSION: Recent climatic changes and frequent international travel have changed the epidemiological spectrum of some infectious diseases. In view of the rapidly growing number of vaccines available and the need to implement massive immunization campaigns in several regions of the world, it is imperative to understand the potential adverse reactions of vaccinations. Neurological disorders are among the most serious, and on rare occasions, life-threatening complications after vaccination.
Les effets secondaires du vaccin antivariolique
Rey, M. (1978). [Smallpox and anti-smallpox measures in 1978: myths and realities]. Nouv Presse Med, 7(22), 1965-1970.
Keywords: Child, Preschool; France; Humans; Infant; Smallpox/epidemiology/*prevention & control; Smallpox Vaccine/administration & dosage/adverse effects; Somalia;
Seelemann, K. (1960). [Cerebral complications after smallpox vaccination with special reference to age disposition in Hamburg from 1939 to 1958.]. Dtsch Med Wochenschr, 85, 1081-1089.
Keywords: *Encephalomyelitis, Acute Disseminated; Smallpox/*immunology; *Encephalitis, Post-Vaccinal; *SMALLPOX/immunology
Collectif. (1966). Rapport d'un groupe scientifique de l'OMS sur les vaccins contre les maladies humaines à virus et à rickettesies. OMS, (325).
Jacquelin, A. (1955). [Dangers of smallpox vaccination in allergy.]. Sem Hop, 31(56), 2913-2916.
Abstract: Dangers de la vaccination antivariolique chez les allergiques
Keywords: Smallpox/*prevention & control; *Vaccination; *Vaccines; *SMALLPOX/prevention and control; *Vaccines And Vaccination
Helman, J. (1957). Vaccinia as a possible carcinogen. The Lancet, 272(1), 50.
Keywords: Keywords: *Carcinogens; Humans; Infant; Middle Aged; Neoplasms/*etiology; Vaccinia/*complications
Les effets secondaires du vaccin antivariolique
Helman, J. (1968). Vaccinia as a possible carcinogen. S Afr Med J, 42(17), 428.
Keywords: *Carcinogens; Humans; Infant; Middle Aged; Neoplasms/*etiology; Vaccinia/*complications
Marmelzat, W. L. (1968). Malignant tumors in smallpox vaccination scars: a report of 24 cases. Arch Dermatol, 97(4), 400-406.
Keywords: Adolescent; Adult; Aged; Carcinogens; Carcinoma, Basal Cell/*etiology; Carcinoma, Squamous Cell/*etiology; Female; Humans; Male; Melanoma/*etiology;
Middle Aged; Neoplasm Recurrence, Local; Skin Neoplasms/*etiology/therapy; Smallpox/*prevention & control; Vaccination/*adverse effects; Vaccinia virus/pathogenicity; Marmelzat, W. L., & Martel, S. (1964). Malignant Melanomas In Smallpox Vaccination Scars. Report Of Six Cases. Arch Dermatol, 89, 823-826.
Keywords: *Arm; *Carcinoma, Squamous Cell; *Cicatrix; *Geriatrics; *Melanoma; *Neoplasm Metastasis; *Nose Neoplasms; *Pathology; *Pregnancy; *Smallpox Vaccine;
*Thigh; *Vaccination; *Arm; *Carcinoma, Epidermoid; *Cicatrix; *Geriatrics; *Melanoma; *Neoplasm Metastasis; *Nose Neoplasms; *Pathology; *Pregnancy; *Smallpox Andersen, H. J., Nilsson, L. R., & Lund, E. (1965). Acute Leukaemia Following Smallpox Vaccination In A Ten-Month-Old Infant. Acta Paediatr Scand, 54, 383-386.
Keywords: *Blood; *Hemoglobinometry; *Infant; *Leukemia; *Leukocyte Count; Neoplasms/*etiology; *Smallpox Vaccine; Vaccination/*adverse effects; *Blood;
*Hemoglobinometry; *Infant; *Leukemia; *Leukocyte Count; *Neoplasm Etiology; *Smallpox Vaccine; *Vaccination; *Vaccination Complications Les effets secondaires du vaccin antivariolique
Michel, N., Aguilera, A., Miller, A., & Miller, A. O. (1976). Vaccinia virus: the possibilities of its oncogenicity in humans. Cancer Lett, 1(4), 225-230.
Abstract: Contrary to the earlier generally accepted view that vaccinia virus replicates in the cytoplasm only of suitable target cells, steadily accumulating data show that the
viral genome spends a limited period of time in the nucleus. This, together with the many cases where a close association has been suspected or established between skin cancer and vaccination, suggests that vaccinia virus may, under certain yet undefined physiological conditions, act as an oncogenic virus in humans.
Keywords: Cell Nucleus/metabolism; DNA Replication; DNA, Viral/biosynthesis; Humans; Immunity, Cellular; Immunotherapy; Melanoma/immunology/therapy; Skin
Neoplasms/*etiology; Smallpox Vaccine/*adverse effects; Transformation, Genetic; Vaccinia virus/immunology/metabolism/*pathogenicity


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