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Microsoft word - 120906 gf irb handbook e regulation 2
THE 2013 PROHIBITED LIST. WORLD ANTI-DOPING CODE
In accordance with Article 4.2.2 of the World Anti-Doping Code, all Prohibited Substances
shall be considered as “Specified Substances” except Substances in classes S1, S2, S4.4, S4.5, S6.a, and Prohibited Methods
M1, M2 and M3.
SUBSTANCES AND METHODS PROHIBITED AT ALL TIMES
(IN- AND OUT-OF-COMPETITION)
S0. NON-APPROVED SUBSTANCES
Any pharmacological substance which is not addressed by any of the subsequent sections of the List and with no current approval by any governmental regulatory health authority for human therapeutic use (e.g drugs under pre-clinical or clinical development or discontinued, designer drugs, substances approved only for veterinary use) is prohibited at all times.
S1. ANABOLIC AGENTS
Anabolic Androgenic Steroids (AAS)
(5α-androst-1-ene-3β,17β-diol ); 1-androstenedione
(estr-4-ene-3β,17β-diol ); bolasterone; boldenone; boldione
diene-3,17-dione); calusterone; clostebol; danazol
(19-norpregna-4-en-17α-ol); fluoxymesterone; formebolone; furazabol
methyl[1,2,5]oxadiazolo[3',4':2,3]-5α-androstan-17β-ol); gestrinone; 4-hydroxytestosterone
(4,17β-dihydroxyandrost-4-en-3-one); mestanolone; mesterolone; metenolone; methandienone
(17β-hydroxy-17α-methylandrosta-1,4-dien-3-one); methandriol; methasterone
(methyltrienolone, 17β-hydroxy-17α-methylestra-4,9,11-trien-3-one); mibolerone;
(estr-4-ene-3,17-dione); norboletone; norclostebol;
norethandrolone; oxabolone; oxandrolone; oxymesterone; oxymetholone; prostanozol
[(tetrahydropyran-2-yl)oxy]-1'H-pyrazolo[3,4:2,3]-5α-androstane); quinbolone; stanozolol;
and other substances with a similar chemical structure or similar biological effect(s).
b. Endogenous** AAS when administered exogenously:
DHEA, 3β-hydroxyandrost-5-en-17-one); testosterone;
and their metabolites and isomers, including but not limited to:
5α-androstane-3α,17α-diol; 5α-androstane-3α,17β-diol; 5α-androstane-3β,17α-diol; 5α-
androstane-3β,17β-diol; androst-4-ene-3α,17α-diol; androst-4-ene-3α,17β-diol; androst-4-ene-
3β,17α-diol; androst-5-ene-3α,17α-diol; androst-5-ene-3α,17β-diol; androst-5-ene-3β,17α-diol;
epi-dihydrotestosterone; epitestosterone; etiocholanolone; 3α-hydroxy-5α-androstan-17-one;
3β-hydroxy-5α-androstan-17-one; 7α-hydroxy-DHEA ; 7β-hydroxy-DHEA ; 7-keto-DHEA;
2. Other Anabolic Agents, including but not limited to:
Clenbuterol, selective androgen receptor modulators (SARMs), tibolone, zeranol, zilpaterol.
* “exogenous” refers to a substance which is not ordinarily capable of being produced by the body naturally.
** “endogenous” refers to a substance which is capable of being produced by the body naturally.
S2. PEPTIDE HORMONES, GROWTH FACTORS AND RELATED SUBSTANCES
The following substances and their releasing factors are prohibited:
1. Erythropoiesis-Stimulating Agents [
e.g. erythropoietin (EPO), darbepoetin (dEPO),
hypoxia-inducible factor (HIF) stabilizers, methoxy polyethylene glycol-epoetin beta
(CERA), peginesatide (Hematide)];
2. Chorionic Gonadotrophin (CG) and Luteinizing Hormone (LH)
4. Growth Hormone (GH), Insulin-like Growth Factor-1 (IGF-1), Fibroblast Growth
Factors (FGFs), Hepatocyte Growth Factor (HGF), Mechano Growth Factors
(MGFs), Platelet-Derived Growth Factor (PDGF), Vascular-Endothelial Growth
as well as any other growth factor affecting muscle, tendon or ligament
protein synthesis/degradation, vascularisation, energy utilization, regenerative capacity or
fibre type switching;
and other substances with similar chemical structure or similar biological effect(s).
S3. BETA-2 AGONISTS
All beta-2 agonists, including all optical isomers (e.g. d-
) where relevant, are prohibited except inhaled salbutamol (maximum 1600 micrograms over 24 hours), inhaled formoterol (maximum delivered dose 54 micrograms over 24 hours) and salmeterol when taken by inhalation in accordance with the manufacturers’ recommended therapeutic regimen.
The presence in urine of salbutamol in excess of 1000 ng/mL or formoterol in excess of 40 ng/mL is presumed not to be an intended therapeutic use of the substance and will be considered as an Adverse Analytical Finding
unless the Athlete
proves, through a controlled pharmacokinetic study, that the abnormal result was the consequence of the use of the therapeutic inhaled dose up to the maximum indicated above.
S4. HORMONE AND METABOLIC MODULATORS
1. Aromatase inhibitors
including, but not limited to: aminoglutethimide, anastrozole,
androsta-1,4,6-triene-3,17-dione (androstatrienedione), 4-androstene-3,6,17 trione (6-
oxo), exemestane, formestane, letrozole, testolactone.
2. Selective estrogen receptor modulators (SERMs)
including, but not limited to:
raloxifene, tamoxifen, toremifene.
3. Other anti-estrogenic substances
including, but not limited to: clomiphene, cyclofenil,
4. Agents modifying myostatin function(s)
including, but not limited, to: myostatin
5. Metabolic modulators:
b) Peroxisome Proliferator Activated Receptor δ (PPARδ) agonists (e.g. GW 1516),
PPARδ-AMP-activated protein kinase (AMPK) axis agonists (e.g. AICAR)
S5. DIURETICS AND OTHER MASKING AGENTS
Masking agents are prohibited. They include:
Diuretics, desmopressin, plasma expanders (
; intravenous administration of
albumin, dextran, hydroxyethyl starch
and mannitol), probenecid;
and other substances with
similar biological effect(s).
Local administration of felypressin in dental anaesthesia is not prohibited.
Acetazolamide, amiloride, bumetanide, canrenone, chlorthalidone, etacrynic acid, furosemide,
indapamide, metolazone, spironolactone, thiazides (
e.g. bendroflumethiazide, chlorothiazide,
; and other substances with a similar chemical structure or
similar biological effect(s) (except drospirenone, pamabrom and topical dorzolamide and
brinzolamide, which are not prohibited).
The use In-
as applicable, of any quantity of a substance subject to threshold limits (i.e. formoterol, salbutamol, cathine, ephedrine, methylephedrine and pseudoephedrine) in conjunction with a diuretic or other masking agent requires the deliverance of a specific Therapeutic Use Exemption for that substance in addition to the one granted for the diuretic or other masking agent.
M1. MANIPULATION OF BLOOD AND BLOOD COMPONENTS
1. The administration or reintroduction of any quantity of autologous, homologous or
heterologous blood or red blood cell products of any origin into the circulatory system.
2. Artificially enhancing the uptake, transport or delivery of oxygen, including, but not limited
to, perfluorochemicals, efaproxiral (RSR13) and modified haemoglobin products (e.g. haemoglobin-based blood substitutes, microencapsulated haemoglobin products), excluding supplemental oxygen.
3. Any form of intravascular manipulation of the blood or blood components by physical or
M2. CHEMICAL AND PHYSICAL MANIPULATION
or attempting to tamper, in order to alter the integrity and validity of Samples
collected during Doping Control
. These include but are not limited to urine substitution and/or adulteration (e.g. proteases).
Intravenous infusions and/or injections of more than 50 mL per 6 hour period except for those legitimately received in the course of hospital admissions or clinical investigations.
M3. GENE DOPING
The following, with the potential to enhance sport performance, are prohibited:
The transfer of polymers of nucleic acids or nucleic acid analogues;
The use of normal or genetically modified cells.
SUBSTANCES AND METHODS
In addition to the categories S0 to S5 and M1 to M3 defined above, the following categories
are prohibited In-Competition:
All stimulants, including all optical isomers (e.g. d-
) where relevant, are prohibited, except imidazole derivatives for topical use and those stimulants included in the 2013 Monitoring Program*.
Adrafinil; amfepramone; amiphenazole; amphetamine; amphetaminil; benfluorex;
benzphetamine; benzylpiperazine; bromantan; clobenzorex; cocaine; cropropamide;
crotetamide; dimethylamphetamine; etilamphetamine; famprofazone; fencamine; fenetylline;
fenfluramine; fenproporex; furfenorex; mefenorex; mephentermine; mesocarb;
methamphetamine(d-); p-methylamphetamine; methylenedioxyamphetamine;
methylenedioxymethamphetamine; modafinil; norfenfluramine; phendimetrazine;
phenmetrazine; phentermine; 4-phenylpiracetam (carphedon); prenylamine; prolintane.
A stimulant not expressly listed in this section is a Specified Substance.
Adrenaline**; cathine***; ephedrine****; etamivan; etilefrine; fenbutrazate; fencamfamin;
heptaminol; isometheptene; levmetamfetamine; meclofenoxate; methylephedrine****;
methylhexaneamine (dimethylpentylamine); methylphenidate; nikethamide; norfenefrine;
octopamine; oxilofrine (methylsynephrine); parahydroxyamphetamine; pemoline;
pentetrazol; phenpromethamine; propylhexedrine; pseudoephedrine*****; selegiline;
sibutramine; strychnine; tuaminoheptane;
and other substances with a similar chemical structure
or similar biological effect(s).
* The following substances included in the 2013 Monitoring Program (bupropion, caffeine, nicotine, phenylephrine, phenylpropanolamine, pipradol, synephrine) are not considered as Prohibited Substances
** Local administration (e.g. nasal, ophthalmologic) of Adrenaline
or co-administration with local
anaesthetic agents is not prohibited.
is prohibited when its concentration in urine is greater than 5 micrograms per milliliter.
**** Each of ephedrine
is prohibited when its concentration in urine is greater
than 10 micrograms per milliliter.
is prohibited when its concentration in urine is greater than 150 micrograms
Buprenorphine, dextromoramide, diamorphine (heroin), fentanyl and its derivatives,
hydromorphone, methadone, morphine, oxycodone, oxymorphone, pentazocine, pethidine.
Natural (e.g. cannabis, hashish, marijuana) or synthetic delta 9-tetrahydrocannabinol (THC) and cannabimimetics (e.g. “Spice”, JWH018, JWH073, HU-210) are prohibited.
All glucocorticosteroids are prohibited when administered by oral, intravenous, intramuscular or rectal routes.
SUBSTANCES PROHIBITED IN PARTICULAR SPORTS
Alcohol (ethanol) is prohibited In-Competition
only, in the following sports. Detection will be conducted by analysis of breath and/or blood. The doping violation threshold (haematological values) is 0.10 g/L.
Unless otherwise specified, beta-blockers are prohibited In-Competition
only, in the following sports.
Archery (FITA) (also prohibited Out-of-Competition
Shooting (ISSF, IPC) (also prohibited Out-of-Competition
Skiing/Snowboarding (FIS) in ski jumping, freestyle aerials/halfpipe and snowboard
Beta-blockers include, but are not limited to, the following:
Acebutolol, alprenolol, atenolol, betaxolol, bisoprolol, bunolol, carteolol, carvedilol, celiprolol,
esmolol, labetalol, levobunolol, metipranolol, metoprolol, nadolol, oxprenolol, pindolol,
propranolol, sotalol, timolol.
Jer. 35:1 ¶ The word which came unto Jeremiah from the LORD in the days of Jehoiakim the son of Josiah king of Judah, saying, Jer. 35:2 Go unto the house of the Rechabites, and speak unto them, and bring them into the house of the LORD, into one of the chambers, and give them wine to drink. Jeremiah’s record is obviously not recorded chronologically. This message from the LORD jum
Chronische lymphatische Leukämie Stand 13.12.2006 Deutsche Gesellschaft für Hämatologie und Onkologie Chronische lymphatische Leukämie Autoren: M. Hallek, B. Eichhorst, P. Dreger Expertengruppe: H. Döhner, P. Dreger, B. Eichhorst, B. Emmerich, M. Hallek 1. Definition und Basisinformation Die WHO-Klassifikation (s. B-9.1) beschreibt die chronische lymphatische Leukämie (CL