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Important: please read

IMPORTANT: PLEASE READ
PART III: CONSUMER INFORMATION
When it should not be used:
Do not take APO-METOPROLOL/APO-
METOPROLOL (Type L)/APO-
PrAPO-METOPROLOL
Metoprolol Tartrate Tablets USP
PrAPO-METOPROLOL (Type L)
allergy to metoprolol tartrate and/or its Metoprolol Tartrate Film-Coated Tablets
ingredients present in APO-METOPROLOL/APOMETOPROLOL SR PrAPO-METOPROLOL SR
Metoprolol Tartrate Slow-Release Tablets
various heart conditions (please consult your This leaflet is part III of a three-part
“Product Monograph” published when APO-
METOPROLOL/APO-METOPROLOL
(Type L)/APO-METOPROLOL SR were
approved for sale in Canada and is designed
anesthesia (blocking the perception of pain specifically for Consumers. This leaflet is a
summary and will not tell you everything
about APO-METOPROLOL/APO-
METOPROLOL (Type L)/APO-
METOPROLOL SR. Contact your doctor or
METOPROLOL SR if you have a heart rate <45 pharmacist if you have any questions about
beats/min; significant heart block greater than the drug.
first degree; systolic blood pressure <100 mmHg; or moderate-to-severe heart failure.
ABOUT THIS MEDICATION
What the medicinal ingredient is:
What the medication is used for:
APO-METOPROLOL/APO-METOPROLOL (Type L)/APO-METOPROLOL SR is used to What the important nonmedicinal ingredients
reduce hypertension (high blood pressure), to treat chest pain (angina), to treat heart failure, and to reduce the risk that a heart attack will monohydrate, microcrystalline cellulose, magnesium stearate, croscarmellose sodium and METOPROLOL/APO-METOPROLOL (Type L)/APO-METOPROLOL SR for another reason. Ask your doctor if you have any questions about (Type L) tablets contain the following inactive ingredients: hydroxypropyl methylcellulose, polyethylene glycol, titanium dioxide, carnauba METOPROLOL SR has been prescribed for you.
wax, D&C Red # 30 Aluminium Lake 30% (50 mg tablet only) Sunset Yellow Aluminum Lake What it does:
tablet only) and polydextrose (100 mg tablet class of drugs called beta-blockers. Metoprolol acts by blocking the action of certain chemicals (hormones) on the heart and the bloodvessels and affects, amongst other things, the heart rate and the heart’s workload.
APO-METOPROLOL SR Tablets contain the following inactive ingredients: methylcellulose, You should avoid operating automobiles and hydroxypropyl methylcellulose, stearic acid, machinery or engaging in other tasks that colloidal silicon dioxide, magnesium stearate, require you to be alert until advised by your methylcellulose, polyethylene glycol, titanium dioxide, yellow ferric oxide and red ferric oxide You should know that liver function tests should be performed at regular intervals during long-term treatment.
What dosage forms it comes in:
APO-METOPROLOL Tablets are available in
INTERACTIONS WITH THIS
MEDICATION
available in 50 and 100 mg strengths.
METOPROLOL/APO-METOPROLOL (Type L)/APO-METOPROLOL SR, tell your doctor if (prescription, non-prescription or herbal).
WARNINGS AND PRECAUTIONS
Tell all doctors, dentists and pharmacists who are treating you that you are taking APO- METOPROLOL SR please tell your doctor if you: Drugs that may interact with APO-METOPROLOL/APO-METOPROLOL (Type antihypertensive drugs (used to treat blood pressure), calcium channel blockers (such as verapamil and diltiazem), nitroglycerin, inhalation anesthetics, prazosin, antidepressants (such as fluoxetine, paroxetine or bupropion), propafenone), antiretrovirals (such as ritonavir), antihistamines (such as diphenhydramine), antimalarials (such as hydroxychloroquine or quinine), antifungals (such as terbinafine), cimetidine or ranitidine), MAO inhibitors or catecholamine-depleting drugs, (such as reserpine or guanethidine).
Caution is indicated in elderly patients.
Digitalis glycosides, cold remedies, nasal drops, If you are an angina patient, you should not painkillers such as indomethacin, rifampin can METOPROLOL/APO-METOPROLOL (Type L)/APO-METOPROLOL SR without (Type L)/APO-METOPROLOL SR may decrease the elimination rate of alcohol from the If you get skin rashes or drying of the eye, body, therefore alcohol use is not recommended for people taking APO-METOPROLOL/APO-METOPROLOL (Type L)/APO- If you have an allergic type reaction, there may be increased difficulty in treating it while you are on this medication.
SIDE EFFECTS AND WHAT TO DO
ABOUT THEM
effect on clonidine, oral antidiabetics and lidocaine.
Like other medications, APO-METOPROLOL/APO-METOPROLOL (Type L)/APO-METOPROLOL SR can cause some side effects. These side effects are most likely to The following laboratory parameters have been be minor and temporary. However some maybe rarely elevated: transaminases, BUN, alkaline The most common side effects reported are PROPER USE OF THIS MEDICATION
exertional tiredness, gastrointestinal disorders and disturbances of sleep patterns.
Usual dose:
SERIOUS SIDE EFFECTS, HOW OFTEN
HAPPEN AND WHAT TO DO ABOUT
Your doctor will initiate treatment with increased depending on your requirement.
These should be taken in the morning and tablets is not recommended since the film This is not a complete list of side effects. For
any unexpected effects that seem unusual or
that are especially bothersome while taking
first talking to your doctor. Stopping APO- APO-METOPROLOL/APO-METOPROLOL
(Type L)/APO-METOPROLOL SR, contact
your doctor or pharmacist.
may cause your condition to become worse. HOW TO STORE IT
Overdose:
If overdosage occurs, in all cases therapy with
All medicines should be kept out of the reach of metoprolol should be discontinued and you should immediately contact your doctor or go to your nearest hospital emergency department. APO-METOPROLOL/APO-METOPROLOL (Type L) tablets should be stored at room Missed Dose:
temperature (15°C to 30°C) and protected from Take the missed dose as soon as you remember. If it is almost time for the next dose however, skip the missed dose and take only the next regularly scheduled dose. Do not take a double stored at room temperature (15°C to 30°C).
The expiry date of this medicine is printed on the package label. Do not use the medicine after this date. If your doctor tells you to stop taking APO-METOPROLOL/APO-METOPROLOL (Type L)/APO-METOPROLOL SR or you find that they have passed the expiry date, please return any left over medicine to your pharmacist.
To monitor drug safety, Health Canada collects information on serious and unexpected effects of drugs. If you suspect you have had a serious or unexpected reaction to this drug you may notify Health Canada by: toll-free telephone: 866-234-2345toll-free fax 866-678-6789By email: cadrmp@hc-sc.gc.ca By regular mail:Canadian Adverse Drug Reaction Monitoring Program(CADRMP)Health CanadaAddress Locator: 0201C2Ottawa, ON K1A 1B9 NOTE: Before contacting Health Canada, you should contact your physician or pharmacist. MORE INFORMATION
For more information, please contact your doctor, pharmacist or other healthcare professional.
This leaflet plus the full product monograph, prepared for health professionals, can be obtained by contacting DISpedia, Apotex's Drug Information Service at 1-800-667-4708 This leaflet can also be found at: http://www.apotex.ca/products.
This leaflet was prepared by Apotex Inc., Toronto, Ontario, M9L 1T9.

Source: http://www.lotusgraphic.ly/ramadamed/pdf/0133_PIL.pdf

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