Wednesday, july 24, 2002
What is FSGS?
FSGS is a disease of the kidney. It can only be
FSGS usually causes protein in the urine
diagnosed by a kidney biopsy. Its name describes
(proteinuria). This may be mild enough that it
Not all of the glomeruli (filtering units)
are involved; scarring in even 1 can make the
produces swelling from the nephrotic syndrome.
Scarring involves only a portion of
nothing that could have prevented it. While it
the filtering unit. If the whole glomerulus were
may respond to treatment, many cases do not.
About half of children with FSGS will develop
This is the medical term
permanent kidney failure within 5 years of their
for scarring of the filtration units (glomeruli) of
FSGS is more common now than it was 30 years
Other findings may be present on the kidney
ago, perhaps because of rising rates of childhood
biopsy that will help predict how your kidneys
are going to do.
How do you diagnose FSGS?
FSGS is diagnosed by kidney biopsy in patients
Other patients may have gene mutations that
with unusual forms of nephrotic syndrome or
contribute to the disorder. You may be asked to
heavy proteinuria with no obvious cause.
have blood tests to examine these possibilities.
Some patients with FSGS have a protein in their
blood that causes the kidney to leak protein.
How do you treat HUS?
The nephrotic syndrome can be treated with
mycophenolate (Cellcept™), another drug that
suppresses the immune system. Another drug,
hydrochlorothiazide (Diuril) or furosemide
rituximab (Rituxan™), can be given by IV. It has
(Lasix) to control swelling. If very severe, a
produced long-lasting remissions in patients with
protein called albumin may be given through the
FSGS, even when the disease occurs after
vein with furosemide to remove swelling. While
transplant. This medication may not be covered
these may control the swelling, they do not treat
In about half of all patients, none of these
Some cases of FSGS will resolve with treatment
treatments work to cure the FSGS. In this case,
with oral steroids (drugs such as prednisone).
blood pressure medications are very important to
Often this does not work and other agents are
keep the kidneys working as long as possible.
used including chemotherapy drugs such as
Other drugs may be needed to control swelling
drugs such as cyclosporine (Neoral™) or
If the kidneys do fail, a kidney transplant can be
tacrolimus (Prograf™). Control of high blood
done. Unfortunately, FSGS may affect the
pressure is also very important in preventing
transplanted kidney and cause it to fail. This does
kidney failure. Drugs such as ACE inhibitors or
not happen every time, and when it does there
others may be used to control this complication.
are therapies that may help delay or reverse
Some newer drugs may produce remission in
patients with FSGS. These include
Nierenfunktionsszintigraphie mit Captopril® und Basisuntersuchung Ziel und Zweck Arbeitsanweisung zur Durchführung einer Nierenfunktionsszintigraphie (ING). Anwendung Allgemeines Mit dem Einsatz tubulär sezernierter Radiopharmaka (MAG3, Hippursäure) kann nicht-invasiv, seitengetrennt die Nierenfunktion bestimmt und mit der zusätzlichen Gabe von ACE-Hemmern (Captopril) die häm
Small Animal Benchmark — November 2008 1) Proposed modified Duke system: The ‘Modified Duke criteria’ were originally proposed by Li et al in 2000, to try to aid the diagnosis of infectious endocarditis in humans. These criteria have been altered for more practical relevance in the diagnosis of infectious endocarditis in canines. These criteria are described by MacDonald (in Kirks Cu