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P E D I AT R I C N E W S • D e c e m b e r 2 0 0 5
Ototoxicity Not Seen With Brief Trial of Cortisporin
B Y P AT R I C E W E N D L I N G
An analysis showed the total cost for us-
ing Cortisporin or a generic was $15,500 at
equivalent for 5 days after ventilation tube
L O S A N G E L E S — Cortisporin Otic did
“The motivation for this study began af-
if Floxin (ofloxacin otic solution 0.3%) had
not cause ototoxicity and was cost effec-
ter our entire group felt significant pres-
$49,500 if Ciprodex (ciprofloxacin 0.3% and
to a large retrospective review at a tertiary
hearing loss was found in 33 ears (3.6%).
sion) had been prescribed at $99 per bottle.
in 19 cases (2.1%). The loss existed prior
tional trial lawyer associations and found
fective, but the cost is significant, Leonard
no evidence of clinical ototoxicity in 500
to surgery in all 19 cases, and there was no
no ototoxicity cases settled in or out of
P. Berenholz, M.D., reported at the annu-
deterioration postoperatively, he said.
aminoglycosides such as Cortisporin indi-cate the potential risk when there is anopen tympanic membrane,” said PaulCockrum, Pharm.D., manager of clinical
The total cost of
or a generic was
$15,500 at $31
a bottle. That
$45,000 if Floxin
prescribed at $90
was formed in 2004 at the request of theAmerican Academy of Otolaryngolo-gy–Head and Neck Surgery Foundationdue to rising legal claims against physi-cians, recommendations by British andCanadian medical organizations to limitthe use of potentially ototoxic ototopicalantibiotics, the availability of nonototox-ic preparations, and a lack of an evidence-based review of these issues.
The panel said, when possible, topical an-
Supporting your pediatric vaccine needs
tibiotic preparations free of potential oto-
every step of the way
toxicity should be used. But the academy haselected not to convert the recommendationsto official policy, said Kenneth Satterfield,media relations director for the academy.
Otic states that, “Neomycin can inducepermanent sensorineural hearing loss dueto cochlear damage, mainly destruction ofhair cells in the organ of Corti” and that“ototoxicity and nephrotoxicity have alsobeen reported,” commented MelvynBloom, M.D., director of medical servicesand safety for Daiichi PharmaceuticalCorp., which markets Floxin Otic.
Based on his findings, Dr. Berenholz rec-
ommends using Cortisporin for less than1 week and reserving the tertiary charac-
To order Sanofi Pasteur Inc. pediatric vaccines, log on to www.vaccineshoppe.com
or call 1-800-VACCINE
ter of fluoroquinolones for resistant oracute cases or difficult chronic ears.
Before administering, please see full Prescribing Information for DAPTACEL, ActHIB, IPOL, Tripedia, and TriHIBit vaccines.
DAPTACEL vaccine is manufactured by Sanofi Pasteur Limited (formerly Aventis Pasteur Limited) and
distributed by Sanofi Pasteur Inc. (formerly Aventis Pasteur Inc.).
ActHIB and IPOL vaccines are manufactured by Sanofi Pasteur SA (formerly Aventis Pasteur SA) and
distributed by Sanofi Pasteur Inc. (formerly Aventis Pasteur Inc.). Tripedia and TriHIBit vaccines are manufactured and distributed by Sanofi Pasteur Inc.
ate children who had ear tubes placedwithout postoperative topical antibioticdrops and those who received Cortisporinor Ciprodex.
U.O. di CHIRURGIA GENERALE Servizio di Gastroenterologia ed Endoscopia Digestiva Responsabile: Dott.ssa Roberta Motta PREPARAZIONE PER COLONSCOPIA CON ISOCOLAN 34,8 GR NORME DI CARATTERE GENERALE 1. Nei tre giorni precedenti l’esame evitare di mangiare frutta, verdura e legumi. 2. Acquistare in farmacia una confezione di ISOCOLAN 34,8 gr che contiene 8 buste. La
CAMP CENTERLAND Date Received ______________________________ HEALTH FORM Reviewed & Initialed Camp Nurse_______________ Reviewed & Initialed by Camp Director___________ PARENTS: PLEASE PRINT, COMPLETE AND SIGN Camper’s Name: ________________________________ Birth Date: ___/___/___ Age: _____ Sex: M F Custodial Parent: ____________________________________________ P