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By Wendy C. Brooks, DVM, DipABVP
Educational Director,
Itch Relief
The Itching Pet: Alternatives to Steroids
Excessive licking, chewing, and scratching can make a pet’s life miserable for month after month, even year after year. For rapid relief of itch and inflammation, nothing matches thecorticosteroid hormones such as cortisone, hydrocortisone, prednisone, dexamethasone, and others.) There are some animals that seem unable to live with any degree of comfort without these medications. Unfortunately, these hormones have widespread and potentially dangerous actions throughout the body when they are used for inappropriately long periods and it is generally desirable to minimize the use of these hormones when possible to do so. Ideally, corticosteroids are used for a few really tough itch weeks and other forms of itch management are used for general itch maintenance. See more detail on long-term corticosteroid use. This is, of course, easier to write about than to actually do. When one's pet is scratching and chewing raw spots on his or her skin, practical advice is called for. The following list includes assorted non-steroidal methods for relieving itch and reducing the amount of corticosteroid hormones needed. Oral Medications
Antihistamine Trials
Histamine, a biological chemical, is the chief mediator of inflammation in humans hence the proliferation of antihistamines available for people both by prescription and over the counter.
Histamine is not the major mediator of inflammation in the dog, thus these medications are not as reliable for dogs as they are for us.
The protocol recommended by this hospital is helpful to approximately 40% of dogs who try it. Four different antihistamines are used, one at a time, at least 2 weeks each, in hope of finding onethat is acceptably effective. While the chance that an individual antihistamine will be helpful is small (about 15%), trying several antihistamines greatly increases the chance of finding one that works. Antihistamines are not free of side effects; they are notorious for drowsiness in some individuals. Still, this is vastly preferable to the systemic disruption caused by the corticosteroid group. Our hospital uses the following antihistamines in a typical antihistamine trial (click for more information): Diphenhydramine(Benadryl)Clemastine fumarate(Tavist)Hydroxyzine(Atarax)Chlorpheniramine(Chlor-Trimeton) In cats, antihistamines are substantially more reliable than in dogs so that the chances of a given antihistamine working are usually pretty good. For both cats and dogs, using antihistamines together with a corticosteroid hormone will decrease the amount of corticosteroid hormone needed to control the itching (i.e., less hormone is needed to get the job done if it is given with an antihistamine).
Fatty Acid Supplementation
The discovery of anti-inflammatory properties of evening primrose oils and fish oils in humans has led to similar products on the market for our pets. These products are not analogous to
the oil supplements that are recommended as food supplements to make a pet's coat shiny; instead; these are true anti-inflammatory drugs capable of relieving joint pain, cramps, and
itchy skin.
The supplement alone is helpful in 10% to 25% of itchy dogs; we often recommend its use in combination with antihistamines to boost the efficacy of the protocol described above. Cyclosporine (Atopica)

Cyclosporineis an immune system modulating drug originally developed for use in organ transplant patients, but which is also useful in other immune-mediated diseases. Since allergy is an
immune-mediated condition, cyclosporine was investigated as an alternative to corticosteroids and found effective for most patients. Currently this medication is being marketed only for dogsand one dog in three will develop an upset stomach when starting the drug (though this resolves or is manageable with dose modification).
Topicals to Try
When using any dip on inflamed skin one should be aware that the use of cool water is considered much more soothing than warm water. Colloidal Oatmeal Shampoos and Creme Rinse - At first, these products were only available for human use, as powdered soaks to pour into bath water. Once their value in itch management
was determined, their use quickly spread to the veterinary field. Colloidal oatmeal actually pulls inflammatory toxis out of the skin, generally yielding 1 to 3 days of relief. The
creme rinses are meant to yield longer acting relief. They are available plain or combined with local anesthetic forumlas to soothe itch.
Lime Sulfur Dip - This product kills parasites, ringworm fungi, and bacteria. It also dries moist, weeping skin lesions and helps dissolve surface skin proteins that are involved in
itchiness. Many veterinary dermatologists recommend it regularly to control itch; however, it has several disadvantages. It smells terrible. The sulfur ingredient
smells like rotten eggs and this is how your bathroom or bathing area will smell during the pet's bath. This dip can stain jewelry and clothing and will temporarily
turn white fur yellow.
Other Shampoos
Itchy skin can be the result of skin infection, excess oil accumulation, yeast infection, even parasitic infection. The list goes on. The shampoo products listed above
can be used against any itchy skin disease but it should be noted that there are many other shampoo and creme rinse products that can be used against the
specific skin diseases listed. If some other type of shampoo product has been prescribed to you for an itchy skin disease, it is important that you use it allowing at least a good 10 minutes of
skin contact time before rinsing.
Colloidal Oatmeal Sprays and Lotions - Same principle as above. These products pull inflammatory toxins out of the skin. Oatmeal products have become very popular and are available as
shampoos, creme rinses, soaks, sprays, and lotions.
Humilac Spray - This moisturizer may be applied as a spray or mixed in water as a dip. It is helpful for dry skin but can also be used in combination with lime sulfur as lime sulfur is naturally
drying to the skin.
Witch Hazel - This product has a cooling effect on the skin that is soothing for both animals and for people with sun burn. It is available as a spray or lotion.
Aloe Vera Gel - If possible, obtain 100% aloe vera gel from a health food store. Products containing aloe are much more available but are generally not as effective and not meant to be licked
away by a pet. Aloe vera gel comes from the aloe vera succulent and contains enzymes which break down inflammatory proteins and enhance healing. Pure aloe vera gel is not harmful for pets
who want to lick it off.
Topical Steroids? - It seems clear that taking steroids orally may be harmful to the body with chronic use but are topical cremes safe for long term use? We now know that topical steroids
(cortisone cremes and related products) are absorbed through the skin and into the bloodstream but the hormonal side effects with topical use do seem blunted. For small irritated areas (hot
spots), topicals can provide excellent relief without the systemic effects of hormones.
Respect the Steroid
Severe itching amounts to a reduction in life quality. It is important not to develop the mindset that corticosteroids should be avoided at all costs. This would not be fair to the itching pet. Steroids are valuable tools in the relief of pain and suffering and have an important place the therapy of the itchy pet. The goal is not to avoid steroid use if possible but to avoid long term dependence on steroids if possible. Despite all of the above management tricks, some pets will still require long term steroid use to achieve any reasonable comfort. There are monitoring protocols in place for such cases. It should also not be forgotten that underlying allergies and recurring skin infections can be addressed specifically and that as these conditions are managed, Steroid hormones have many side effects and, as helpful as they are for allergic skin diseases, it is best to reserve them for only the most itchy episodes.
It is our policy not to give dosing information over the Internet.
Date Published: 1/1/2001Date Reviewed/Revised: 6/14/2007 Copyright 2007 - 2008 by the Veterinary Information Network, Inc. All rights reserved.
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