BRITISH PHARMACOPOEIA CHEMICAL REFERENCE SUBSTANCE MATERIAL SAFETY DATA SHEET
The substance to which this Safety Data Sheet relates is supplied exclusively as a British Pharmacopoeia Chemical Reference Substance (BPCRS) for chemical test and assay purposes. It is not intended to be used for any other purpose and is not for human consumption. The BPCRS is supplied in accordance with the Terms of Trade and Supply as set out in the catalogue. The information set out in this sheet is applicable solely to the substance when used as a BPCRS and is not intended to apply to any other use or preparation of the substance (e.g. at different concentrations, in drug dosage form or in bulk quantities). The information which follows has been assembled from sources considered reliable, in particular from material provided in the ordinary way by the manufacturer or supplier. It has not been independently verified by the British Pharmacopoeia. The accuracy of the information cannot therefore be guaranteed, nor does it constitute any expression of opinion by the British Pharmacopoeia concerning the substance. This information is not to be regarded as a representation or statement concerning the quality or safety of the substance except that of use as a BPCRS by professional persons having technical skill and at their own discretion and risk. All persons using BPCRS materials must determine the risks associated with the substance depending on the actual conditions of use and should take appropriate measures. Information given in sections 2, 3, 4, 5, 6, 9, 10, 11, 12 and 13 relates to the bulk substance and is not necessarily relevant to the BPCRS regarding the small quantities contained in vials. Information in sections 1, 7, 8 and 14 applies only to the BPCRS. 1. IDENTIFICATION OF THE SUBSTANCE AND OF THE COMPANY
CHLORTETRACYCLINE HYDROCHLORIDE BPCRS This substance is a mixture of antibiotics. Information given in this MSDS refers to the main component; chlortetracycline hydrochloride. British Pharmacopoeia Commission Secretariat
Telephone: +44 (0)20 70840 2561 (office hours) Emergency telephone: +44 (0)20 70840 2561 (office hours) Reference standard for laboratory use 2. HAZARDS IDENTIFICATION Irritating to eyes, respiratory system and skin. Possible risk of harm to the unborn child. May cause harm to breastfed babies. May cause an allergic reaction, especially in case of pre-existing sensitivity to similar substances. May be harmful to the environment. Symbol: Xn R phrases: R36/37/38, R63, R64 3. COMPOSITION/INFORMATION ON INGREDIENTS
C22H24Cl2N2O8 4. FIRST AID MEASURES
Inhalation: Remove to fresh air. If breathing becomes difficult, call a physician. Skin contact: Flush with copious amounts of water and soap for at least 15 minutes. Remove contaminated clothing and shoes. Eye contact: Assure adequate flushing by separating the eyelids with fingers. Flush with copious amounts of water for at least 15 minutes. Ingestion: Wash out mouth with water and administer fresh water provided that the person is conscious. In any case seek medical advice and call the nearest poison centre. Show the label and this safety data sheet.
5. FIRE FIGHTING MEASURES
Extinguishing media: Water spray. Carbon dioxide, dry chemical powder or appropriate foam. Avoid overspills into drains, surface and groundwater and soil. Dust may form explosive mixture in air. Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. Emits toxic fumes under fire conditions. Dangerous combustion products: COx, NOx, HCl and other noxious gases or vapours in case of incomplete combustion.
6. ACCIDENTAL RELEASE MEASURES
Wear self-contained breathing apparatus, rubber boots and heavy rubber gloves. Switch off sources of ignition and intense heat. Collect residues manually, wipe with sodium hypochlorite solution until residues have been removed, place in a bag and hold for waste disposal. Avoid raising dust or mist. Ventilate area and wash spill site with sodium hypochlorite after material pick up is complete. Keep away from drains, surface and groundwater and soil. 7. HANDLING AND STORAGE
Handling: Handle small quantities in fume hood. Avoid inhalation. Avoid contact with eyes, skin and clothing. Avoid prolonged or repeated exposure. Storage: Keep unopened in the original container at about 2-8 °C. Protect from heat, direct sunlight and moisture. 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Respiratory protection: Protecting mask (filter P1). Hand protection: Compatible chemical-resistant gloves. Eye protection: Wear protective chemical safety goggles. 9. PHYSICAL AND CHEMICAL PROPERTIES
Appearance: Yellow powder. Solubility: Slightly soluble in water and in alcohol. It dissolves in solutions of alkali hydroxides and carbonates. 10. STABILITY AND REACTIVITY Materials to avoid: Strong oxidizing agents. Dangerous decomposition products: COx, NOx, HCl and other substances in case of incomplete decomposition.
11. TOXICOLOGICAL INFORMATION
RTECS No: QI7800000 (chlortetracycline hydrochloride) and Q1910000 (tetracycline hydrochloride) LD50 (oral-mouse): 2314 mg/kg Reproductive toxicity (development of foetus) has been reported in humans with tetracycline hydrochloride. Toxicity to fertility and reproduction has been reported in animal studies. See actual entry in RTECS for complete information. CMR Classification: Repr. Cat. 3 12. ECOLOGICAL INFORMATION PBT index (Janus) 5 (tetracycline hydrochloride). Biodegradation is uncertain, may bioaccumulate or have direct ecotoxic effects. The substance may have inhibitory effects on the activity of micro-organisms and an impact on sewage treatment plants and environment, including risk of introducing antimicrobial resistance. Information on the mobility, biodegradability and persistence in nature is not available. 13. DISPOSAL CONSIDERATIONS
Incinerate in an approved facility. Observe all federal state and local environmental regulations.
14. TRANSPORT INFORMATION
Not classified. 15. REGULATORY INFORMATION
Symbol: Xn Risk phrases: R36/37/38, R63, R64 Safety phrases: S36/S37 CMR Classification: Repr. Cat. 3 16. OTHER INFORMATION
R36/37/38: Irritating to eyes, respiratory system and skin. R63: Possible risk of harm to the unborn child. R64: May cause harm to breastfed babies. S36/37: Wear suitable protective clothing and gloves.
nineteen years on the job Part 2 of a 2-part article by Lindy Dunagan-Groger [Volume 12 Number 2 (June 2002) features part 1 of this article] n the year that Michael turned 18 I transitioned into a new set of I am an organized documentation- issues — those of parenting and being person; I have kept all those papers and a young adult. This included officially obtaining disabili
Contraceptive Choices This leaflet gives a brief summary of the methods of contraception. A more detailed leaflet isavailable for each of the methods. All the methods of contraception listed below are effective. However, no method is 100% reliable. The reliability foreach method is given in percentages. For example, the contraceptive injection is more than 99% effective. Thismeans that les
BRITISH PHARMACOPOEIA CHEMICAL REFERENCE SUBSTANCE 
4. FIRST AID MEASURES 
13. DISPOSAL CONSIDERATIONS