09.45 Key lecture: Vladimir Uversky: Did you mis- it or non-? Protein folding, 10.25 Pierre Goloubinoff - University of Lausanne, Switzerland: Oxana V. Galzitskaya - Institute of Protein Research, Russia: How to determine the size of folding nuclei of protofibrils from the concentration dependence of the rate and lag-time of aggregation? Experimental application for insulin and LysPro insulin 11.30 Claudio M. Gomes, Universidade Nova de Lisboa, Portugal: Small molecules at the rescue of misfolded proteins Alberto Barbiroli, University of Milan, Italy: Dissecting the stabilizing effects of polyols on protein structure Rajiv Bhat, Jawaharlal Nehru University, India: Understanding solvent-mediated protein stability effects: spectroscopic and calorimetric studies on glucose oxidase in the presence of polyols Jianxing Song, National University of Singapore, Singapore: Why are Aggregated Proteins Toxic? Secrets of “Insoluble Proteins” Eduardo P. Melo, University of Algarve, Portugal:Osmolytes induce compaction of the protein tertiary structure preventing amyloid fiber formation and protein aggregation below the freezing temperature 15.00 Liel Sapir - The Hebrew University of Jerusalem, Israel: How osmolytes induce enthalpic protein stabilization Marina Rubini - University of Konstanz, Germany: (4R)- and (4S)- Fluoroproline in the Conserved cis-Prolyl Peptide Bond of the Thioredoxin Fold: Tertiary Structure Context Dictates Ring Puckering Josè Luis Vázquez-Ibar - Autonomous University of Barcelona: A general strategy to build stability in a membrane transport protein for Pannuru Venkatesu, University of Delhi, India: Ammonium ionic liquids as biocompatible co-solvents for the structure and stability of proteins 16.50 Reinhard Boysen, Monash University, Australia: Effects of salt types on protein shape determined by small angle X-ray scattering Paul Dalby, University College London, UK: Rapid measurement of protein stability in nanolitre samples using optically induced thermal Andreas Zimmer, University of Graz, Austria: Thermostability of protein formulations: Screening in combination with design of Ulrich Roessl, Graz University of Technology, Austria: Probing conformational stability of pharmaceutical proteins in the frozen state Anna Oom, Biolin Scientific, Sweden: QCM-D in protein drug formulation and storage 18.50 Welcome Cocktail @ poster session 3. Methods to improve stability and solubility: Protein engineering 09.00 Key lecture: Donald Hilvert, ETH, Zurich, Switzerland: Directed evolution of intrinsically disordered enzymes Vladimir I. Tishkov, Lomonosov Moscow State University, Russia: Engineering stability and catalytic properties of D-amino acid oxidase Ayelet Fishman, Technion, Haifa, Israel: Different means of stabilizing enzymes in organic solvents – a tale of two enzymes Javier Sancho, University of Zaragoza, Spain: The divide and combine approach for protein thermostabilization Anastasia Alekseeva, Lomonosov Moscow State University, Russia: Synergetic effect of several single point mutations on stability and kinetic properties of plant formate dehydrogenase 4. Methods to improve stability and solubility: media and supports Key lecture: Karl-Erich Jaeger, Düsseldorf, Germany: CATIBs – highly stable, catalytically-active enzyme inclusion bodies Rafael Vazquez-Duhalt, Universidad Nacional Autonoma de Mexico, Mexico:Virus-like nanoparticles As potential carriers of cytochrome P450 for chemotherapy pro-drug activation Carmen Boeriu, Biobased Products, The Netherlands: Increasing operational stability of oleate hydratase by immobilization Tamo Fukamizo, Kinki University, Japan: Unusual stabilization effects of oligosaccharide binding on chitosan-binding proteins 15.30 Imre Hegedus - University of Pannonia, Hungary: Enzyme stabilization as single enzyme nanoparticles for hydrolysis of Christophe Tribet - Ecole Normale Superieure, France: Toward artificial photo-chaperons: unfolding of model enzymes upon interaction with light-responsive polymers in water Ipsita Roy - Natl Institute of Pharmaceutical Education and Res., India: Nucleic acid aptamers as potential ‘universal’ stabilizers of proteins Christopher Schoene - University of Oxford, UK: SpyTag/SpyCatcher ligation confers resistance to boiling to a mesophilic enzyme 17.20 Giuseppe Bellavia - Université Lille, France: Role of glycerol on trehalose to enhance biostability in relation with fast anharmonic and quasi-harmonic motion Valentina Aina - University of Torino, Italy: Novel smart bio-nanomaterials for protein immobilization: bioactive glasses containing metal nanoparticles conjugated with proteins 09.00 Key lecture: Paolo Carloni - Forschungszentrum Jülich, Germany: Investigating the stability of proteins against aggregation by simulation Vytas Švedas - Lomonosov Moscow State University, Russia: Computational design of stabilized penicillin acylase to improve its catalytic performance in alkaline medium George Makhatadze - Rensselaer Polytechnic Institute, USA: Effect of ionizable residues on the folding energy landscape of globular proteins: linking experiment and computation. Koen Beerens - Masaryk University, Czech Republic: Reliable in silico design of highly stable multiple-point mutants of haloalkane dehalogenase Juergen Pleiss - University of Stuttgart, Germany: Simulation of activity and stability of C.antarctica lipase B under non-natural conditions 6. Stability towards industrial applications 11.30 Key lecture: Massimo Morbidelli, ETH, Zurich, Switzerland Role of Aggregation in the Manufacturing and Formulation of Jan Jezek - Arecor, Cambridge, UK: Innovative approaches to Alessandra Basso - Purolite, South Wales UK: Designing immobilized transaminases for fast screening for hits in the development of new pharmaceutical molecules 15.00 Frank Hollmann - TU Delft, The Netherlands: On the mutual inactivation of transition metals and enzymes Marc Vanhove, Thrombogenics N.V., Belgium: Inactivation of ocriplasmin in eye vitreous: a complex mechanism unraveled by Sebastiana Angelaccio, University of Roma, Italy: Cofactor binding as protein stability determinant in psychrophilic SHMT Willem J.J. van Berkel, Wageningen University, The Netherlands: Bifunctional immobilization of a hyperthermostable endo ß 1,3 Mariam M. Nuhu, University of Manchester, UK: Effect of dipeptides as novel formulation excipients in insulin aggregation and stabilization Christopher Sayer, University of Exeter, UK: Thermostable Enzymes for Industrial Biocatalysis


UPDATED PROTOCOL OF THE EUROCARE HIGH RESOLUTION STUDIES ON CARE OF CANCER PATIENTS INTRODUCTION Eurocare is a “Concerted Action” of European population-based cancer registries (CRs) which deals with survival and care of cancer patients. On the basis of the past experience of Eurocare, the collection of some clinical variables (stage and basic diagnostic investigations p

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