August MIMS Monthly Medicine Update NEW PRODUCTS
leading to urinary glucose excretion (glucuresis).
a release liner. It is indicated for the treatment of
Gastaut epilepsy types who are not adequately
in the central nervous system with an active
Bydureon (exenatide) is an extended release
Forxiga is indicated in type 2 diabetes (with diet,
tobacco dependence by relieving nicotine craving
stabilized with their current anticonvulsant
inflammatory process, if alternative diagnoses
microsphere formulation of exenatide. Exenatide
exercise) as: monotherapy when metformin not
and withdrawal symptoms, thereby facilitating
have been excluded, and if they are determined
is a glucagon-like peptide-1 (GLP-1) receptor
tolerated; initial combination with metformin
smoking cessation in smokers motivated to quit.
to be at high risk of developing clinically definite
Galvumet (vildagliptin/metformin
agonist that exhibits several antihyperglycaemic
when diet, exercise inadequate and poor response
For smokers who are currently unable or not
multiple sclerosis. High risk can be inferred from
hydrochloride) is now indicated in combination
actions of GLP-1. Exenatide suppresses glucagon
ready to stop smoking immediately, the Nicorette
cerebral MRI with 2 or more lesions suggestive of
with a sulphonylurea (i.e. triple combination
secretion which is known to be inappropriately
combination with metformin, sulfonylurea or
25 mg/16 hour Invisipatch can also be used for
therapy) as an adjunct to diet and exercise in
elevated in type 2 diabetes. Exenatide is indicated
insulin (+/- metformin and/or sulfonylurea) when
two weeks by people who smoke 15 or more
patients inadequately controlled with metformin
Trajenta (linagliptin) is now indicated in
for the treatment of type 2 diabetes mellitus in
diet, exercise, existing therapy inadequate. It
cigarettes per day in a preparation phase to reduce
adults with type 2 diabetes mellitus to improve
combination with metformin or sulfonylurea or
is contraindicated in moderate to severe renal
the need to smoke prior to stopping smoking
glycaemic control in conjunction with diet
metformin + sulfonylurea in patients who have not
impairment. Forxiga is available as 10 mg tablets
immediately. It is contraindicated in generalised
Galvus (vildagliptin) is now indicated in triple
and exercise as monotherapy when metformin
achieved adequate glycaemic control. Exenatide
skin disease eg psoriasis, chronic dermatitis,
combination with a sulfonylurea and metformin
and sulfonylureas are not tolerated or are
is contraindicated in patients with end-stage renal
urticaria; non-tobacco users and in children <
Imojev (Japanese encephalitis vaccine) is a
when diet and exercise plus dual therapy with
contraindicated; or as add on to metformin,
disease or severe renal impairment (creatinine
12 yrs. Nicorette 16hr Invisipatch is available
monovalent, live attenuated viral vaccine specific
these agents do not provide adequate glycaemic
sulfonylureas or metformin plus sulfonylureas; or
clearance < 30 mL/min). Bydureon is available as
in 25mg/16hr (22.5cm2) in packs of 7’s, 14’s;
to the Japanese encephalitis virus. Imojev is
to insulin (with or without metformin).
a once weekly powder for injection supplied in a
15mg/16hr (13.5cm2) and 10mg/16hr (90cm2)
indicated for prophylaxis of Japanese encephalitis
in packs of 7 patches each. Each system contains
Inspra (eplerenone) is now indicated to
caused by the Japanese encephalitis virus, in
nicotine at a concentration of 1.75mg/cm2.
reduce the risk of cardiovascular mortality and
SAFETY RELATED CHANGES
Clobex (clobetasol propionate) is a topical
individuals from 12 months of age and over.
morbidity in adult patients with NYHA Class II
Daivobet 50/500 Gel (calcipotriol +
corticosteroid with anti-inflammatory, antipruritic,
Imojev is contraindicated in febrile, acute disease
NEW INDICATIONS
(chronic) heart failure and left ventricular systolic
betamethasone dipropionate) is now
and vasoconstrictive properties. It is postulated
(postpone admin); congenital, acquired immune
dysfunction (LVEF ≤ 30% or LVEF ≤ 35% in
contraindicated in perianal and genital pruritus.
that corticosteroids induce lipocortins that
Cialis (tadalafil) is now indicated in moderate
addition to QRS duration of > 130 msec), in
control the biosynthesis of potent mediators
eg chemotherapy, high systemic corticosteroid
to severe lower urinary tract symptoms (LUTS)
addition to standard optimal therapy.
The combination of Erbitux (cetuximab (rmc))
of inflammation such as prostaglandins and
for 14 days (wait for at least 1 month after
associated with benign prostatic hyperplasia
with oxaliplatin containing chemotherapy is
leukotrienes by inhibiting the release of their
interruption of therapy) and HIV infection
Janumet (sitagliptin phosphate monohydrate/
contraindicated for patients with mutant K-RAS
common precursor, arachidonic acid. Clobex
(symptomatic or asymptomatic when associated
metformin hydrochloride) is now indicated
Daivobet 50/500 Gel (calcipotriol +
metastatic colorectal cancer (mCRC) or for whom
is indicated as a topical treatment of moderate
with impaired immune function). Imojev is also
betamethasone dipropionate) K-RAS mCRC status is unknown.
to severe scalp psoriasis in adults. Clobex is
contraindicated in pregnancy and lactation.
in the topical treatment of mild to moderate
Protos (strontium ranelate) is now
contraindicated in skin areas affected by bacterial,
Imojev is available as a powder for injection with
sulfonylurea does not provide adequate glycaemic
plaque psoriasis on the body in adults.
contraindicated in patients with a history of
viral (varicella, herpes simplex, herpes zoster),
ischaemic heart disease, peripheral arterial
fungal or parasitic infections and specific skin
Menitorix (haemophilus b conjugate vaccine
Eliquis (apixaban) is now indicated in stroke,
Januvia (sitagliptin phosphate monohydrate)
disease or cerebrovascular disease. It is also
diseases (skin tuberculosis, skin diseases caused
+ neisseria meningitidis vaccine) is indicated
systemic embolism prevention in patients with
is now indicated as triple combination therapy
contraindicated in those with a systolic blood
by lues). Clobex must not be applied to the eye
for the prevention of invasive diseases caused
nonvalvular atrial fibrillation and at least 1
pressure greater than or equal to 160 mmHg, or
and eyelids (risk of glaucoma, risk of cataract)
by Haemophilus influenzae type b (Hib) and
combination therapy with both agents does not
diastolic blood pressure greater than or equal to
or to ulcerous wounds. It is also contraindicated
Neisseria meningitidis serogroup C (MenC).
Erbitux (cetuximab (rmc)) is now indicated
in children less than 2 years of age. Clobex is
Menitorix is contraindicated in those who are
in combination with infusional 5-fluorouracil/
available as a 125 ml shampoo for 16 days of
allergic to the tetanus toxoid. Menitorix is
Mabthera (rituximab) in combination with
folinic acid plus irinotecan. It is also indicated in
Rimycin (rifampicin) use is now contraindicated
available as a powder for injection vial with 0.5
glucocorticoids is now indicated for the induction
combination with irinotecan in patients who are
when given concurrently with the combination of
of remission in patients with severely active
Forxiga (dapagliflozin propanediol
ml of diluent in a pre-filled syringe in packs of
refractory to first-line chemotherapy, and as first-
Granulomatosis with polyangiitis (GPA, also
monohydrate) is an orally active inhibitor of
line treatment in combination with FOLFOX.
known as Wegener’s granulomatosis) and
the human renal sodium glucose cotransporter 2
This list is a summary of only some of the
Nicorette 16hr Invisipatch (nicotine) contains
Frisium (clobazam) is now indicated in children
(SGLT2), with nanomolar potency that improves
changes that have occurred over the last month.
nicotine in a thin, semi-transparent multi-layered
(4 years of age and over) as adjunctive therapy
glycemic control in patients with type 2 diabetes
Before prescribing, always refer to the full product
patch, comprising of a pre-coated backing layer,
Rebif (interferon beta-1a) is now indicated
in patients with partial refractory and Lennox-
mellitus by reducing renal glucose reabsorption
a nicotine source layer, a skin adhesive layer and
in patients with a single demyelinating event
Research in Autism Spectrum Disorders 4 (2010) 526–538J o u r n a l h o m e p a g e : h t t p : / / e e s . e l s e v i e r . c o m / R A S D / d e f a u l t . a s pAn in-depth examination of optimal outcome children with a history ofautism spectrum disordersElizabeth Kelley Letitia Naigles, Deborah FeinUniversity of Connecticut, Department of Psychology, Storrs, CT 06269-1020, USAPrevi
Tranexamic Acid (CyclokapronR) This is only taken during bleeding and can reduce the menstrual flow by up to half. It is not a hormone but acts on blood clotting inside the womb. It does not increase the risk of thrombosis (unwanted blood clots) elsewhere in the body although you would not be offered it if you have had a thrombosis in the past. Some people feel nauseous with the tablets but oth