Chloroform MSDS Number: C2915 * * * * * Effective Date: 07/02/09 * * * * * Supercedes: 05/04/07 Synonyms: Trichloromethane; Methyl trichloride; Methane trichlorideCAS No.: 67-66-3Molecular Weight: 119.38Chemical Formula: CHCl3Product Codes:J.T. Baker: 9174, 9175, 9180, 9181, 9182, 9183, 9184, 9186, 9187, 9188, 9257Mallinckrodt: 1473, 2175, 4432, 4434, 4439, 4440, 4441, 4443, 4444, H407, V551 2. Composition/Information on Ingredients Ingredient CAS No Percent Hazardous --------------------------------------- ------------ ------------ --------- Chloroform 67-66-3 98 - 100% Yes Ethyl Alcohol 64-17-5 0 - 1% Yes Emergency Overview--------------------------DANGER! MAY BE FATAL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. CAUSESIRRITATION TO SKIN, EYES AND RESPIRATORY TRACT. MAY AFFECT CENTRAL NERVOUS SYSTEM,CARDIOVASCULAR SYSTEM, LIVER AND KIDNEYS. SUSPECT CANCER HAZARD. MAY CAUSECANCER. Risk of cancer depends on level and duration of exposure.
SAF-T-DATA(tm) Ratings (Provided here for your convenience)-----------------------------------------------------------------------------------------------------------Health Rating: 3 - Severe (Poison)Flammability Rating: 1 - SlightReactivity Rating: 1 - SlightContact Rating: 3 - Severe (Life)Lab Protective Equip: GOGGLES & SHIELD; LAB COAT & APRON; VENT HOOD; PROPER GLOVESStorage Color Code: Blue (Health)----------------------------------------------------------------------------------------------------------- Potential Health Effects---------------------------------- Inhalation:Acts as a relatively potent anesthetic. Irritates respiratory tract and causes central nervous system effects, includingheadache, drowsiness, dizziness. Exposure to higher concentrations may result in unconsciousness and even death. Maycause liver injury and blood disorders. Prolonged exposure may lead to death due to irregular heart beat and kidney andliver disorders.
Ingestion:Causes severe burning in mouth and throat, pain in the chest and vomiting. Large quantities may cause symptoms similarto inhalation.
Skin Contact:Causes skin irritation resulting in redness and pain. Removes natural oils. May be absorbed through skin.
Eye Contact:Vapors causes pain and irritation to eyes. Splashes may cause severe irritation and possible eye damage.
Chronic Exposure:Prolonged or repeated exposure to vapors may cause damage to the nervous system, the heart and the liver and kidneys.
Contact with liquid has defatting effect and may cause chronic irritation of skin with cracking and drying, andcorresponding dermatitis. Chloroform is a suspected human carcinogen.
Aggravation of Pre-existing Conditions:Persons with pre-existing skin disorders or eye problems, or impaired liver, kidney or respiratory function may be moresusceptible to the effects of the substance.
Inhalation:Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medicalattention.
Ingestion:If swallowed, DO NOT INDUCE VOMITING. Give large quantities of water. Never give anything by mouth to anunconscious person. Get medical attention immediately.
Skin Contact:Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Getmedical attention immediately. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eye Contact:Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Getmedical attention immediately.
Note to Physician:Because kidney and liver effects may be delayed, keep victim under observation for 24 to 48 hr. Administration of fluidsmay help to prevent kidney failure. Obtain blood glucose, urinalysis, liver function tests, chest x-ray, and monitor cardiacfunction and fluid/electrolyte status. Monitor liver and kidney function for 4 to 5 days after exposure. Disulfiram, itsmetabolites, and a high carbohydrate diet appear to protect somewhat against chloroform toxicity. Do not give adrenalin!Tests may show increased bilirubin, ketosis, lowered blood prothombin, and fibrogen.
Fire:Slight fire hazard when exposed to high heat; otherwise, practically not flammable.
Explosion:Sealed containers may rupture when heated.
Fire Extinguishing Media:Use any means suitable for extinguishing surrounding fire.
Special Information:In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with fullfacepiece operated in the pressure demand or other positive pressure mode. Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Isolate hazardarea. Keep unnecessary and unprotected personnel from entering. Contain and recover liquid when possible. Collect liquidin an appropriate container or absorb with an inert material (e. g., vermiculite, dry sand, earth), and place in a chemicalwaste container. Do not use combustible materials, such as saw dust. Do not flush to sewer! US Regulations (CERCLA)require reporting spills and releases to soil, water and air in excess of reportable quantities. The toll free number for the USCoast Guard National Response Center is (800) 424-8802.
J. T. Baker SOLUSORB® solvent adsorbent is recommended for spills of this product.
Keep in a tightly closed light-resistant container, stored in a cool, dry, ventilated area. Protect against physical damage.
Isolate from incompatible substances. Wear special protective equipment (Sec. 8) for maintenance break-in or whereexposures may exceed established exposure levels. Wash hands, face, forearms and neck when exiting restricted areas.
Shower, dispose of outer clothing, change to clean garments at the end of the day. Avoid cross-contamination of streetclothes. Wash hands before eating and do not eat, drink, or smoke in workplace. Containers of this material may behazardous when empty since they retain product residues (vapors, liquid); observe all warnings and precautions listed forthe product. Chloroform odor threshold: 250 mg/m3. The odor threshold only serves as a warning of exposure; notsmelling it does not mean you are not being exposed.
Airborne Exposure Limits:Chloroform:-OSHA Permissible Exposure Limit (PEL):50 ppm (TWA) Ceiling-ACGIH Threshold Limit Value (TLV):10 ppm (TWA), Listed as A3 animal carcinogen For Ethyl Alcohol:- OSHA Permissible Exposure Limit (PEL):1,000 ppm (TWA)- ACGIH Threshold Limit Value (TLV):1,000 ppm (STEL), A3 - Confirmed animal carcinogen with unknown relevance to humans.
Ventilation System:A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne ExposureLimits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at itssource, preventing dispersion of it into the general work area. Please refer to the ACGIH document, IndustrialVentilation, A Manual of Recommended Practices, most recent edition, for details.
Personal Respirators (NIOSH Approved):If the exposure limit is exceeded and engineering controls are not feasible, wear a supplied air, full-facepiece respirator,airlined hood, or full-facepiece self-contained breathing apparatus. Breathing air quality must meet the requirements ofthe OSHA respiratory protection standard (29CFR1910.134). This substance has poor warning properties.
Skin Protection:Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skincontact.
Eye Protection:Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Appearance:Clear, colorless liquid.
Odor:Characteristic ethereal odor.
Solubility: 0.8g/100g water @ 20C (68F).
Specific Gravity:1.48 @ 20C/4CpH:No information found.
% Volatiles by volume @ 21C (70F):100Boiling Point:62C (144F)Melting Point:-63.5C (-83F)Vapor Density (Air=1):4.1Vapor Pressure (mm Hg):160 @ 20C (68F)Evaporation Rate (BuAc=1):11.6 Stability:Stable under ordinary conditions of use and storage. pH decreases on prolonged exposure to light and air due to formationof HCl.
Hazardous Decomposition Products:May produce carbon monoxide, carbon dioxide, hydrogen chloride and phosgene when heated to decomposition.
Hazardous Polymerization:Will not occur.
Incompatibilities:Strong caustics and chemically active metals such as aluminum, magnesium powder, sodium, or potassium; acetone,fluorine, methanol, sodium methoxide, dinitrogen tetroxide, tert-butoxide, triisopropylphosphine.
Conditions to Avoid:Light, heat, air and incompatibles.
Toxicological Data:Chloroform: oral rat LD50: 908 mg/kg; skin rabbit LD50: > 20 gm/kg; inhalation rat LC50: 47702 mg/m3/4H; irritationdata: skin rabbit 10 mg/24H open mild; eye rabbit: 20 mg/24H moderate; investigated as a tumorigen, mutagen,reproductive effector.
Reproductive Toxicity:Birth defects have been seen in rats and mice exposed by inhalation of chloroform at concentrations greater than 100 ppmin air. Ingestion of chloroform by pregnant laboratory animals has resulted in fetotoxicity but not birth defects, and only atlevels causing severe maternal effects.
--------\Cancer Lists\------------------------------------------------------ ---NTP Carcinogen--- Ingredient Known Anticipated IARC Category ------------------------------------ ----- ----------- ------------- Chloroform (67-66-3) No Yes 2B Ethyl Alcohol (64-17-5) No No None Environmental Fate:When released into the soil, this material is expected to leach into groundwater. When released into the soil, this materialis expected to quickly evaporate. When released to water, this material is expected to quickly evaporate. When releasedinto the water, this material is expected to have a half-life between 1 and 10 days. This material has a log octanol-waterpartition coefficient of less than 3.0. This material is not expected to significantly bioaccumulate. When released into theair, this material may be moderately degraded by reaction with photochemically produced hydroxyl radicals. Whenreleased into the air, this material may be moderately degraded by photolysis. When released into the air, this material may be removed from the atmosphere to a moderate extent by wet deposition. When released into the air, this material isexpected to have a half-life of greater than 30 days.
Environmental Toxicity:This material is not expected to be toxic to aquatic life. The LC50/96-hour values for fish are over 100 mg/l.
Whatever cannot be saved for recovery or recycling should be handled as hazardous waste and sent to a RCRA approvedwaste facility. Processing, use or contamination of this product may change the waste management options. State andlocal disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents inaccordance with federal, state and local requirements.
Domestic (Land, D.O.T.)-----------------------Proper Shipping Name: RQ, CHLOROFORMHazard Class: 6.1UN/NA: UN1888Packing Group: IIIInformation reported for product/size: 52L International (Water, I.M.O.)-----------------------------Proper Shipping Name: CHLOROFORMHazard Class: 6.1UN/NA: UN1888Packing Group: IIIInformation reported for product/size: 52L --------\Chemical Inventory Status - Part 1\--------------------------------- Ingredient TSCA EC Japan Australia ----------------------------------------------- ---- --- ----- --------- Chloroform (67-66-3) Yes Yes Yes Yes Ethyl Alcohol (64-17-5) Yes Yes Yes Yes --------\Chemical Inventory Status - Part 2\--------------------------------- --Canada-- Ingredient Korea DSL NDSL Phil.
----------------------------------------------- ----- --- ---- ----- Chloroform (67-66-3) Yes Yes No Yes Ethyl Alcohol (64-17-5) Yes Yes No Yes --------\Federal, State & International Regulations - Part 1\---------------- -SARA 302- ------SARA 313------ Ingredient RQ TPQ List Chemical Catg.
----------------------------------------- --- ----- ---- -------------- Chloroform (67-66-3) 10 10000 Yes No Ethyl Alcohol (64-17-5) No No No No --------\Federal, State & International Regulations - Part 2\---------------- -RCRA- -TSCA- Ingredient CERCLA 261.33 8(d) ----------------------------------------- ------ ------ ------ Chloroform (67-66-3) 10 U044 No Ethyl Alcohol (64-17-5) No No No Chemical Weapons Convention: No TSCA 12(b): No CDTA: NoSARA 311/312: Acute: Yes Chronic: Yes Fire: No Pressure: NoReactivity: No (Mixture / Liquid) WARNING:THIS PRODUCT CONTAINS A CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE CANCER.
Australian Hazchem Code: 2ZPoison Schedule: S6WHMIS:This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR) and theMSDS contains all of the information required by the CPR.
Risk of cancer depends on level and duration of exposure.
Label Precautions:Do not breathe vapor.
Do not get in eyes, on skin, or on clothing.
Keep container closed.
Use only with adequate ventilation.
Wash thoroughly after handling.
Label First Aid:In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removingcontaminated clothing and shoes. Wash clothing before reuse. If inhaled, remove to fresh air. If not breathing, giveartificial respiration. If breathing is difficult, give oxygen. If swallowed, DO NOT INDUCE VOMITING. Give largequantities of water. Never give anything by mouth to an unconscious person. In all cases get medical attentionimmediately.
Product Use:Laboratory Reagent.
Revision Information:MSDS Section(s) changed since last revision of document include: 8.
Disclaimer:************************************************************************************************Mallinckrodt Baker, Inc. provides the information contained herein in good faith but makes no representation asto its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionaryhandling of the material by a properly trained person using this product. Individuals receiving the informationmust exercise their independent judgment in determining its appropriateness for a particular purpose.
************************************************************************************************Prepared by: Environmental Health & SafetyPhone Number: (314) 654-1600 (U.S.A.)


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