Proposition 65 no significant risk levels (nsrls) for carcinogens and maximum allowable dose levels (madls) for chemicals causing reproductive toxicity
Office of Environmental Health Hazard Assessment Proposition 65 No Significant Risk Levels (NSRLs) for Carcinogens and Maximum Allowable Dose Levels (MADLs) for Chemicals Causing Reproductive Toxicity
Below is a list of NSRLs and MADLs that provide "safe harbor" for businesses subject to the requirements of Proposition 65. These NSRLs and MADLs are established in regulation in Title 27, Cal. Code of Regulations, Sections 25705, 25709 and 25805. These safe harbor levels do not preclude the use of alternative levels that can be demonstrated by their users as being scientifically valid. A hyperlink is provided for those NSRLs or MADLs for which the documentation of their derivation is electronically available. Chemical NSRL (µg/day)a MADL (µg/day)a
A-alpha-C (2-Amino-9H-pyrido[2,3-b]indole)
AF-2;[2-(2-furyl)-3-(5-nitro-2-furyl)]acrylamide
2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole
Office of Environmental Health Hazard Assessment Proposition 65 No Significant Risk Levels (NSRLs) for Carcinogens and Maximum Allowable Dose Levels (MADLs) for Chemicals Causing Reproductive Toxicity Chemical NSRL (µg/day)a MADL (µg/day)a
Chlorinated paraffins (Average chain length, C12;approximately 60 percent chlorine by weight)
Chloromethyl methyl ether (technical grade)
Office of Environmental Health Hazard Assessment Proposition 65 No Significant Risk Levels (NSRLs) for Carcinogens and Maximum Allowable Dose Levels (MADLs) for Chemicals Causing Reproductive Toxicity Chemical NSRL (µg/day)a MADL (µg/day)a
Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone)
4,4'-Diaminodiphenyl ether (4,4'-Oxydianiline)
Office of Environmental Health Hazard Assessment Proposition 65 No Significant Risk Levels (NSRLs) for Carcinogens and Maximum Allowable Dose Levels (MADLs) for Chemicals Causing Reproductive Toxicity Chemical NSRL (µg/day)a MADL (µg/day)a
trans-2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2-furyl)vinyl]-1,3,4-oxadiazole
Office of Environmental Health Hazard Assessment Proposition 65 No Significant Risk Levels (NSRLs) for Carcinogens and Maximum Allowable Dose Levels (MADLs) for Chemicals Causing Reproductive Toxicity Chemical NSRL (µg/day)a MADL (µg/day)a
2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole
Glu-P-1 (2-Amino-6-methyldipyrido[1,2- a:3',2'-d]imidazole)
Glu-P-2 (2-Aminodipyrido[1,2-a:3',2'-d]imidazole)
Gyromitrin (Acetaldehyde methylformylhydrazone)
IQ (2-Amino-3-methylimidazo[4,5-f] quinoline)
Me-A-alpha-C (2-Amino-3-methyl-9H-pyrido[2,3-b]indole)
MeIQ (2-Amino-3,4-dimethylimidazo[4,5-f]quinoline
MeIQx (2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline)
Office of Environmental Health Hazard Assessment Proposition 65 No Significant Risk Levels (NSRLs) for Carcinogens and Maximum Allowable Dose Levels (MADLs) for Chemicals Causing Reproductive Toxicity Chemical NSRL (µg/day)a MADL (µg/day)a
4,4'-Methylene bis(N,N-dimethyl)benzenamine
2-Methyl-1-nitroanthraquinone (of uncertain purity)
5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)-amino]-2-oxazolidinone
MX (3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone)
Nickel refinery dust from the pyrometallurgical process
Nitrilotriacetic acid, trisodium salt monohydrate
1-[(5-Nitrofurfurylidene)-amino]-2-imidazolidinone
N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide
Office of Environmental Health Hazard Assessment Proposition 65 No Significant Risk Levels (NSRLs) for Carcinogens and Maximum Allowable Dose Levels (MADLs) for Chemicals Causing Reproductive Toxicity Chemical NSRL (µg/day)a MADL (µg/day)a
4-(N-Nitrosomethylamino)-1-(3-pyridyl)1-butanone
Office of Environmental Health Hazard Assessment Proposition 65 No Significant Risk Levels (NSRLs) for Carcinogens and Maximum Allowable Dose Levels (MADLs) for Chemicals Causing Reproductive Toxicity Chemical NSRL (µg/day)a MADL (µg/day)a
2,3,7,8-Tetrachlorodibenzo-p -dioxin (TCDD)
Tris(1-aziridinyl)phosphine sulfide (Thiotepa)
Tris(1,3-dichloro-2-propyl) phosphate (TDCPP)
Vinyl trichloride (1,1,2-Trichloroethane)
a Where a source or product results in exposures by multiple routes, the total exposure must be considered. For example, the MADL for benzene is exceeded when the absorbed dose exceeds 24 µg/day. If only inhalation and oral exposure occurs, the benzene MADL is exceeded when: (oral dose ÷ 24 µg/day) + (inhalation dose ÷ 49 µg/day) > 1.0.
b Butyl benzyl phthalate MADL was adopted June 25, 2013, but pursuant to Government Code section 11343.4 it becomes effective October 1, 2013.
c Levels for male children and adolescents were calculated by application of the default bodyweights specified in Section 25703(a)(8) to the procedure specified in Sections 25801 and 25803, Title 27, California Code of Regulations. Office of Environmental Health Hazard Assessment Proposition 65 No Significant Risk Levels (NSRLs) for Carcinogens and Maximum Allowable Dose Levels (MADLs) for Chemicals Causing Reproductive Toxicity Chemical NSRL (µg/day)a MADL (µg/day)a
d Level represents absorbed dose (rounded from 6,525 µg/day ). Since 100% of ingested toluene is absorbed, oral dose is equivalent to administered dose. It is assumed that roughly 50% of the dose administered by the inhalation route is absorbed. Therefore the MADL for inhaled toluene is 13,000 µg/day (rounded from 13,050 µg/day ), corresponding to an absorbed dose of 6,525 µg/day.
WHO 6-stappenplan voor therapie/farmacotherapieGeneesmiddelen bij verminderde nierfunctieBeknopt overzicht van de referentiewaarden van het centraal klinisch-chemisch laboratorium van het Erasmus Medisch Centrum te RotterdamBeknopt overzicht van de referentiewaarden van concentratiesvan geneesmiddelen in bloed bij toepassing van gebruikelijketherapeutische doseringenGeneesmiddeleninteracties v
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