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Herald of Medicine Vol124 No12 February 2005 Beuers U , Boyer J L , Paumgart ner G1 Ursodeoxycholic acid in cho2 lestasis: potential mechanisms of action and t herapeutic application [J ]1 Hepatology , 1998 , 28 (6) : 1449 - 14531 Poupon R , Chazouilleres O , Poupon R E1 Chronic cholestatic dis2 eases[J ]1 J Hepatol , 2000 ,32 (Suppl 1) : 129 - 1401 Van C M , Elerink R P , Groen A K , et al1 Effects of ursodeoxy2 cholate and cholate feeding on liver disease in FVB mice wit h a disrupted mdr2 P2glycoprotein gene [J ] 1 Gast roenterology , 1996 , Paumgart ner G , Beuers U1 Ursodeoxycholic acid in cholestatic liver disease: mechanisms of action and t herapeutic use revisited [ J ] 1 Hepatology , 2002 , 36 (3) : 525 - 5311 Alpini G , Baiochchi l , Glaster S , et al1 Ursodeoxycholate and taur2 oursodeoxycholate inhibit cholangiocyte growt h and secretion of BDL rates t hrough activation of P KC alpha [J ] 1 Hepatology , 2002 , 35 Beuers U , Bilzer M , Chittatt u A , et al1 Tauroursodeoxycholic acid insert s t he apical conjugate export pump , Mrp2 , into canalicular membranes and stimulates organic anion secretion by protein kinase c2dependent mechanisms in cholestatic rat liver [ J ] 1 Hepatology , Fichert P , Zollner G , Fuchsbichler A , et al1 Effects of ursodeo2 xycholic and cholic acid feeding on hepatocellular t ransporter expression in mouse liver [ J ] 1 Gast roenterology , 2001 , 121 ( 1 ) : Kurz A K , Graf D , Schmitt M , et al1 Tauroursodeoxycholate2 1995-2006 Tsinghua Tongfang Optical Disc Co., Ltd. All rights reserved. induced choleresis involves p38 ( MAP K) activation and t ranslocation Brites D , Rodrigues C M , Oliveira N , et al1 Correction of maternal of t he bile salt export pump in rat s [J ] 1 Gast roenterology , 2001 , serum bile acid profile during ursodeoxycholic acid t herapy in cholestasis of pregnancy[J ]1 J Hepatol , 1998 , 28 (1) : 91 - 981 Noe J , Hagenbuch B , Meier P J , et al1 Characterization of the Brites D , Rodrigues C M1 Elevated levels of bile acids in colostrum mouse bile salt export pump over expressed in t he baculovirus of patient s wit h cholestasis of pregnancy are decreased following system[J ]1 Hepatology , 2001 , 33 (5) : 1223 - 12311 ursodeoxycholic acid t herapy[J ]1 J Hepatol , 1998 , 29 (5) : 743 - Lazaridis K N , Gores G J , Lindor K D1 Ursodeoxycholic acid mec2 hanisms of action and clinical use in hepatobiliary disorders [J ] . J Rodrigues C M , Marin J G , Brites D1 Bile acid patterns in meco2 Hepatol , 2001 , 35 (1) : 134 - 1461 nium are influenced by cholestasis of pregnancy and not altered by Benz C , Angermuller S , Tox U , et al1 Effect of taurorusodeoxy2 ursodeoxycholic acid t reat ment [J ]1 Gut , 1999 , 45 (3) : 446 - 4521 cholic acid on bile2acid2induced apoptosis and cytolysis in rat Mazzella G , Rizzo N , Azzaroli F , et al1 Ursodeoxycholic acid admi2 hepatocytes [J ]1 J Hepato , 1998 , 28 (1) : 99 - 1061 nist ration in patient s wit h cholestasis of pregnancy : effect s on Rodrigues C , Fan G , Wong P , et al1 Ursodeoxycholic acid may primary bile acids in babies and mot hers[J ]1 Hepatology , 2001 , 33 mitochondrial t ransmembrane potential and reactive oxygen species Williamson C , Gorelid J , Eaton B M , et al1 The bile acid taurocho2 production[J ]1 Mol Med , 1998 ,4 (3) : 165 - 1781 late impairs rat cardiomyocyte function : a proposed mechanism for Qiao L , Yacoub A , St uder E , et al1 Inhibition of the MAP K and int rauterine fetal deat h in obstet ric cholestasis [J ]1 Cli n Sci , 2001 , PI3 K pat hways enhances UDCA2induced apoptosis in primary rodent hepatocytes[J ]1 Hepatology , 2002 , 35 (4) : 779 - 7891 Lee W Y , Han S H , Cho T S , et al1 Effect of ursodeoxycholic acid Laifer S A , Stiller R J , Siddiqui D S , et al1 Ursodeoxycholic acid on ischemia/ reperfusion injury in isolated rat heart [J ]1 A rch Pharm for t he t reat ment of int rahepatic cholestasis of pregnancy [ J ] 1 J M atern Fet al Med , 2001 , 10 (2) : 131 - 1351 Serrano M A , Brites D , Larena M G , et al1 Beneficial effect of Berkane N , Cocheton J J , Brehier D , et al1 Ursodeoxycholic acid in urso2deoxycholic acid on alterations induced by cholestasis of int rahepatic cholestasis of pregnancy1 A retrospective study of 19 pregnancy in bile acid t ransport across t he human placenta [J ] 1 J cases[J ]1 Acta Obstet Gynecol Scand , 2000 , 79 (11) : 941 - 946 1 Hepatol , 1998 , 28 (5) : 829 - 8391 Nicast ri P L , Diaferia A , Tartagni M1 A randomised placebocontr2 Zapata R1 UDCA in the treatment of intrahepatic cholestasis of preg2 olled t rial of ursodeoxycholic acid and sadenosylmet hionine in t he nancy1 A 102year experience on it efficacy , safety and the perinatal t reat ment of int rahepatic cholestasis of pregnancy [J ] 1 B r J Obstet outcome[J ]1 Gast roentenrology , 2000 ,118 (Suppl 4) : 1001 Gy naecol , 1998 , 105 (11) : 1205 - 1207 1 1995-2006 Tsinghua Tongfang Optical Disc Co., Ltd. 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