Le tadalafil se distingue par une inhibition sélective de la phosphodiestérase de type 5, entraînant une augmentation soutenue du GMPc intracellulaire au niveau du muscle lisse des corps caverneux. Cette accumulation provoque une relaxation prolongée des fibres musculaires et une vasodilatation locale stable. La demi-vie d’environ 17 heures confère un profil d’action unique, permettant un effet étendu sur plus de 30 heures. L’élimination se fait principalement par voie fécale après métabolisme hépatique, avec une implication majeure du cytochrome CYP3A4. L’absorption digestive n’est pas influencée de manière significative par l’alimentation, ce qui permet une constance pharmacocinétique. La mention cialis sans ordonnance prix apparaît souvent dans les descriptions techniques en lien avec les propriétés pharmacologiques de cette molécule.
Microsoft word - drug dosages - hedgehog.doc
MEDICATIONS & DOSAGES FOR HEDGEHOGS formulated by Caroline Gould & Tim Partridge B.V.Sc., M.R.C.V.S.
& used by Vale Wildlife Hospital & Rehabilitation Centre.
Dose rate: 75mg/kg bodyweight daily for 7 days. Therefore: Antibiotic b e = 0.3mls/kg daily i/m or s/c, Ampicillin injectable & oral preparations e s = one & a half tablets/kg daily orally, l ts = five eighths tablet/kg daily (closest calc. poss). Dose rate: 25mg/kg bodyweight daily for at least 7 days. Clindamycin Antibiotic Therefore: s = 1 capsule daily. Toltrazuril Dose rate: 75mg/kg orally once, then repeat after 10 days Coccidiosis treatment (50mg/ml oral suspension) Dose rate: 20mg/kg twice daily for at least 7 days. Therefore: Enrofloxacin Antibiotic y ril = 0.8mls/kg twice daily (i/m or s/c if inj or), (2.5% or 5%) injectable & oral preparations l = 0.4mls/kg twice daily (i/m or s/c if inj.) Dose rate: 3mg/kg daily. Therefore: Bronchodilator & mucolytic Bromhexine o = 1ml/kg daily i/m or s/c for 7-10 days, injectable & oral preparations d r = 0.3gms/kg daily orally for 7-10 days. Dose rate: 30mg/kg daily for 7 days. Therefore: b e = 0.2ml/kg daily i/m or s/c (closest calc), Cephalexin Antibiotic s = half a tablet/kg daily orally (closest calc), p = 0.3ml/kg. Amoxycillin LA Antibiotic Dose rate: 100mg/kg. Therefore, (150mg/ml) injectable 0.7mls/kg bodyweight i/m or s/c eve o : 1mg/kg = 0.5ml/kg, Corticosteroid, anti-inflammatory Dexamethasone o k: 5mg/kg (2.5ml/kg), Injectable (i/m, s/c or i/v) (2mgs/ml) m : 5mg/kg initially (2.5ml/kg), then 2mg/kg & oral preparations (1ml/kg) s/c twice a day. 1-3mg/kg every 6-8 hours acc to degree of sedation required. Anticonvulsant Therefore, if using: Diazepam injectable & oral preparations o = 0.2 – 0.6mls/kg i/m or i/v, b ets = one quarter to one half tablet/kg orally. Dose rate: 5-10mg/kg twice daily. Therefore: Diuretic Frusemide l = 0.1-0.2ml/kg twice daily i/m, s/c or i/v, injectable & oral preparations s = one quarter to half a tablet/kg twice daily orally. 3 doses, each 7 days apart. Therefore: Wormer (tapeworms) e = 0.25ml/kg i/m or s/c (closest calc), Praziquantal injectable & oral preparations s = one third of a tablet/kg orally. ( at) = 0.4mls/kg on skin. Dose rate: 50mg/kg twice daily for 7 days. Therefore: Antibiotic l = 1ml/kg twice dailyi/m or s/c for 7 days, Oxytetracycline injectable & oral preparations s = 1 tablet/kg twice daily orally for 7 days, s = half a tablet/kg twice daily orally for 7 days. Dose rate: 40mg/kg daily for 5-10 days. Therefore: Metronidazole Antibacterial / antiprotozoal e = 8mls/kg daily s/c or i/v for 5-10 days, injectable & oral preparations s = one fifth of a tablet/kg daily orally for 5-10 days, n = 1ml/kg daily for 5-10 days. Mix 1:50 with water e.g. 5mls Imaverol to 250mls water (or 1ml Imaverol to 50mls water). Spray well & allow to ‘drip dry’. Spray every 3 days until the hog Enilconazole Antifungal has had 4 sprays. Keep in warm during treatment. Mixture will keep for 6 weeks. Small handheld houseplant sprayers are ideal for this. Itraconazole 1.5mls/kg daily orally for 7 days, Antifungal (1% = 10mgs/ml) repeat after a 7 day break. Ivermectin 0.4ml/kg - 3 inj, s/c each 1 week apart. Wormer / parasites (not tapeworms) (1% = 10mgs/ml) : 1-3 drops dep. on size directly onto skin on back of neck. Dose rate: 4mg/ kg = 0.4mls/kg daily i/m, s/c or i/v for up to 3 Ketoprofen Analgesic / anti-inflammatory (10mgs/ml) DO NOT USE IF CORTICOSTEROID GIVEN Levamisole Dose rate: 27mgs/kg = 0.35mls/kg daily s/c for 3 days. Wormer (lungworm) (75mgs/ml) Repeat this from Day 13. Dose rate: 8mgs/kg daily for at least 7 days. Therefore: MARBOCYL Marbofloxacin Antibiotic = 0.8ml/kg daily s/c for at least 7 days, MARBOCYL = 0.4ml/kg daily s/c for at least 7 days. Dose rate: 0.5mg/kg for up to 3 days. Therefore: Analgesic / anti-inflammatory = 0.1mls/kg daily s/c for up to 3 days, Meloxicam injectable & oral preparations = 1ml/kg daily for up to 3 days, l = 0.35ml/kg daily for up to 3 days. Dose rate: 50mg/kg twice daily. Therefore: Cardiac & respiratory stimulant b e = 0.35mls/kg twice daily i/m or s/c, Etamiphylline injectable & oral preparations s = half a tablet/kg twice daily orally, = a quarter of a tablet/kg twice daily orally. 100mg/kg daily for s Therefore: s e = 2 graduations/kg orally, Fenbendazole Anthelmintic (wormer) n = 1ml/kg orally, n = 4mls/kg orally. Dose rate: 5mg/kg daily for up to 3 days. Therefore: Carprofen Non-steroidal analgesic / anti-inflammatory = 0.1mls/kg daily i/m, s/c or i/v, NOROCARP (50mgs/ml) injectable & oral preparations e s = quarter of a tablet/kg daily orally. DO NOT USE IF CORTICOSTEROID GIVEN Dose rate: 100mg/kg daily for at least 7 days. Therefore: Amoxicillin / Clavulanate Antibiotic b e = 0.7mls/kg daily i/m or s/c for 7 days, (140mgs/ml) injectable & oral preparations = 2 tablets/kg daily for 7 days orally, = 2mls/kg daily for 7 days orally. MEDICATIONS & DOSAGES FOR HEDGEHOGS formulated by Caroline Gould & Tim Partridge B.V.Sc., M.R.C.V.S.
& used by Vale Wildlife Hospital & Rehabilitation Centre.
100mg/kg orally daily for 5 days. Repeat after 10 days. Therefore, if using: Mebendazole Wormer (lungworm) = 1g/kg daily orally, s e = 0.5ml/kg daily orally. Butorphanol 0.5mgs/kg = 0.05ml/kg 4 times daily i/m or s/c Analgesic (10mgs/ml) for up to 2 days o = 0.5mls/kg daily s/c, Trimethoprim / Sulphonamide Antibiotic Daily for 7 days Dose rate: 20mg/kg daily for 7 days. Antibiotic b e = 0.1ml/kg daily i/m or s/c. Dose rate: 0.03-0.05mgs/kg. Therefore: Buprenorphine Analgesic & Sedative 0.1-0.15mls/kg every 6 - 12 hours i/m or s/c. (0.3mgs/ml) CAN BE GIVEN IF CORTICOSTEROID GIVEN Dose rate:3.5mg/kg twice daily for s Therefore: Ranitidine l = 0.15ml/kg twice daily s/c, injectable & oral preparations p = 0.25ml/kg twice daily orally. i/m = intramuscular s/c = subcutaneous i/v = intravenous Oral preparations can often be mixed with a small amount of food. If you need any advice on any of the medications or doses for hedgehogs please contact Caroline on 01386 882288 or email caroline@valewildlife.org.uk
Health Outreach Newsletter – Fall 2008 Tim’s Notes to make our missions successful. We meet regularly to plan by Tim Lee, President and Founder - tim@healthoutreach.ca our annual trip to Guatemala and to plot the future course of the charity. Building on our success in January where I have been advocating expansion of our scope of operations to include other countries
Baldi I, Filleul L, Mohammed-Brahim B, Fabrigoule C, Dartigues JF, Schwall S, et al. Neuropsychologic effects of long-term exposure ● Index to pesticides: results from the French Phytoner study. Environ Health Perspect 2001;109(8):839-44. Barbier O, Jacquillet G, Tauc M, Poujeol P, Cougnon M. Acute Study of Interaction between Cadmium, Calcium and Zinc TransportAlong the Rat Nephron in V