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Hydroxycut Review
 

By Elizabeth Myers, RD
Hydroxycut is currently of the most familiar weight-loss supplements on the market. It is heavily advertised on television and sold in 70 countries worldwide. Hydroxycut claims to cause fast weight loss, increased energy, and a controlled appetite. The supplement costs $44.99/bottle for 150 capsules, which is quite expensive for a weight loss supplement, especially considering that they suggest you take 2 capsules an hour before every meal for a total of six capsules/day. Product Claims vs. Scientific Evidence
Hydroxycut’s web site states: “All the ingredients in Hydroxycut are of the highest quality and combine to make Hydroxycut one of the most effective weight-loss supplements available on the market” and, “Hydroxycut has been a trusted weight-loss product for one reason – because it works!” Also on their website, they have four research abstracts discussing the outcomes (of course, all positive) of studies that were done on the specific ingredients that are in Hydroxycut. The truth is, however, that the effectiveness of this product has not been scientifically proven. Additionally, research has not proven the long term safety or effectiveness of herbal supplements that are not regulated by the FDA. What has been reported, however, is a long list of Hydroxycut’s side effects. These include, but not limited to: nose bleeds, high blood pressure, increased heart rate, headaches, acne, blurred vision, dizziness, and restlessness.
Active Ingredients
Hydroxycut’s “synergistic blend of research-proven ingredients” consists of: • Chromium: stabilizes blood sugar and decreases cholesterol • Potassium: reduces fluid accumulation in body • Garcinia cambogia extract: hydroxycitric acid - suppresses appetite, carb-blocker • Gymnema Sylvestre extract: maintains blood sugar and insulin level • Glucomannan: a dietary fiber – delays glucose absorption • Alpha lipoic acid: an antioxidant, regulates blood sugar • Willow bark extract: an anti-inflammatory • Green Tea: an antioxidant, increases metabolism • Caffeine: enhances energy and metabolism, reduces fluid accumulation in the body • Guarana seed extra: a stimulant that is high in caffeine, which enhances energy and metabolism, and reduces fluid accumulation in the body Hydroxycut 
Hydroxycut, currently sold in the US without ephedra, is a dieting product which is touted to help 
customers lose weight. Hydroxycut is sold at major retailers such as GNC and Wal‐Mart in addition to 
direct marketing email and TV advertising. 
 
The catch is simple; increases metabolism, reduced hunger, lose weight. However, like the bulk of these 
types of products, there is little scientific evidence to back these claims up and what evidence there is is 
questionable. 
 
In 2003, Hydroxycut was brought to court for false claims. The lawsuit pointed to the company, Muscle 
Tech’s, own research stating that there was no difference in weight loss against a placebo. There was 
also the question of Hydroxycut with ephedra and the side effects, including death, which were not 
properly disclosed on the package. The lawsuit was settled with a 100,000 payout by Muscle Tech yet 
admitted no wrongdoing. 
 
The truth about Hydroxycut is a little more grey. It seems that the ephedra was really the hook; and that 
the side effects with ephedra made Hydroxycut too dangerous a product to market. 
 
Yet now that Hydroxycut has no ephedra especially, there is the question of whether there are any 
health benefits? Some of the companies marketing paint a bleak picture. Apparently the before and 
after photos of one woman in particular were rather misleading. They were taken “months apart” and in 
one she had just given birth. Not a very honest depiction. 
 
Also the past medical side effects of the Hydroxycut formula leads a person with common sense to 
believe that there really are no medical benefits and that the whole product is just a lot of hot air. 
 
We need honesty in advertising and marketing. Especially for weight loss supplements; the people who 
have resorted to these measures are either extreme in their beliefs or they are desperate to have 
something work, so they shouldn’t be lied to or shown false results as they will automatically think that 
they too can be that same person, by merely taking the supplement. Words and the truth are things that 
shouldn’t ever be minced with. 
J Med. 2004;35(1‐6):33‐48. Links  An overview of the safety and efficacy of a novel,
natural(-)-hydroxycitric acid extract (HCA-SX) for
weight management.
Preuss HG, Rao CV, Garis R, Bramble JD, Ohia SE, Bagchi M, Bagchi D. 
Department of Physiology, Medicine and Pathology Georgetown University Medical Center, Washington, DC 20057, USA. Garcinia cambogia-derived (-)-hydroxycitric acid (HCA) is a safe, natural supplement for weight management. HCA is a competitive inhibitor of ATP citrate lyase, a key enzyme which facilitates the synthesis of fatty acids, cholesterol and triglycerides. Previous studies in our laboratories have demonstrated the superior bioavailability of a novel calcium-potassium salt of HCA derived from Garcinia cambogia (HCA-SX, Super CitriMax). Greater bioavailability of HCA-SX was observed when taken on an empty stomach. HCA-SX was also shown to exhibit concentration-dependent release of serotonin in isolated rat brain cortex, which may explain its appetite suppressive action. Acute oral, acute dermal, primary dermal irritation, primary eye irritation and 90-day chronic toxicity studies, as well as Ames bacterial reverse mutation and mouse lymphoma tests, were assessed to determine the safety of HCA-SX. In the 90-day toxicity study, dose- and time-dependent effects of HCA-SX were assessed on body weight, selected organ weights, hepatic and testicular lipid peroxidation and DNA fragmentation, hematology and clinical chemistry, and histopathology in male and female Sprague-Dawley rats. No remarkable toxicity results were detected, demonstrating the safety of HCA-SX. Furthermore, clinical studies to evaluate the safety and efficacy of HCA-SX over a period of eight weeks were conducted in 60 human volunteers. Subjects were given a 2,000 kcal diet/day, participated in a 30 min walking exercise program 5 days/week and given an oral dose of placebo or 4666.7 mg HCA-SX (providing 2,800 mg HCA) in three equally divided doses 30-60 min before meals, Body weight, BMI, lipid profiles, serum leptin, serotonin and excretion of urinary fat metabolites were determined at 0, 4 and 8 weeks of treatment. At the end of 8 weeks, body weight and BMI decreased by 5.4% and 5.2%, respectively. Food intake, total cholesterol, LDL, triglycerides and serum leptin levels were significantly reduced, while HDL and serotonin levels, and excretion of urinary fat metabolites (a biomarker of fat oxidation) significantly increased. No significant adverse effects were reported. These results demonstrate the safety, bioavailability and efficacy of HCA-SX in weight management. Hypertensive retinopathy associated with use of the
ephedra-free weight-loss herbal supplement
Hydroxycut.
Willis SL, Moawad FJ, Hartzell JD, Iglesias M, Jackson WL. 
Department of Internal Medicine, Walter Reed Army Medical Center, Washington, DC, USA. scott.willis2@na.amedd.army.mil The use of performance-enhancing and weight-loss supplements is prevalent in the United States, and over the past decade, there has been growing concern with regard to the safety and efficacy of these products. It is well documented that ephedra-based products are associated with adverse reactions, including serious cardiovascular and neurologic injuries. With new restrictions placed on such products, companies are now marketing caffeine-based ephedra-free herbal supplements. Less is known about the potential side effects of these products. We present the case of a 42-year-old, previously healthy man who developed malignant hypertension and hypertensive retinopathy while taking Hydroxycut, a caffeine-based ephedra-free supplement. To our knowledge, this is the first documented case of hypertensive retinopathy associated with the use of Hydroxycut. Given the lack of investigative studies in regard to their safety and efficacy, judicious care should be taken with the use of all herbal supplements, including those designated as ephedra-free. J Med. 2002;33(1‐4):247‐64. Links  Citrus aurantium as a thermogenic, weight-reduction
replacement for ephedra: an overview.
Preuss HG, DiFerdinando D, Bagchi M, Bagchi D. 
Department of Physiology, Medicine and Pathology, Georgetown University Medical Center, Washington, DC 20057, USA. preusshg@georgetown.edu Obesity is a serious health problem throughout the world. More than half of U.S. adults are overweight (61%) and more than a quarter (26%) of U.S. adults are obese. The inability of many individuals to keep their weight in check by diet and exercise has created a need for additional therapeutic means to combat obesity. Despite great effort, the pharmaceutical industry has not come up with the solution; because most weight-loss drugs to date have serious adverse effects to health and well-being. The theory that beta agonists, especially beta 3 agonists, can affect body weight and fat mass is well accepted. Ephedrine has proven time and time again that it is an effective weight loss agent through its ability to increase thermogenesis and quench appetite. However, the publicity concerning adverse reactions has led to its gradual withdrawal from use by many despite the perceived consequences of obesity. Many companies are now substituting Citrus aurantium for ephedra in their formulations. Citrus aurantium, an agent containing beta agonists, has been reported to aid in weight loss in two studies and increase thermogenesis, at least to some extent, in three studies. Colker et al. (1999) reported that in a double-blind, placebo-controlled, randomized study the subjects receiving a combination of Citrus aurantium, caffeine and St John's Wort, lost significant amounts of total body weight while on a strict diet and exercise. Those in the placebo and control groups who also were on the same restricted diet did not. However, intergroup analysis showed no statistical significance among the weight changes in the three groups. In contrast, the loss of fat mass in the test group was significantly greater compared to the placebo and control groups. Jones describes an open labeled study performed on 9 women. The subjects showed a mean of 0.94 kg lost during the first week when no product was given and 2.40 kg during the second week when a Citrus aurantium product was taken. Body weight losses were statistically greater during the second week compared to the first week. Since most clinicians would agree that the most weight loss should occur initially coinciding with a greater fluid loss during the first week, these differences are even more remarkable. Three studies reported increased metabolic rates when ingesting Citrus aurantium products, however, at least two of these studies were acute. At present, Citrus aurantium may be the best thermogenic substitute for ephedra. However, more studies are needed to establish this definitively. Web sites to visit for unbiased opinions on popular weight loss supplements. http://seniorjournal.com/NEWS/Alerts/2007/7-01-05-WeightLossPills.htm http://www.ncbi.nlm.nih.gov/pubmed/17406200?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum http://altmedicine.about.com/od/popularhealthdiets/a/hoodia1.htm The U.S. Food and Drug Administration rang in the New Year with a ban on the controversial supplement ephedra. Spurred by the death of Baltimore Orioles pitcher Steve Bechler and the rising concerns of health professionals, the agency made the sale of products containing the dangerous substance illegal. Yet, as millions of athletes continue to look for the competitive edge, what are the "ephedra-free" alternatives? What's in them? How are they being marketed? And, more importantly, what should you know about them? Here's a brief recap.   Not long ago, a colleague showed me a new product being marketed as an ephedra-free dietary supplement specifically for athletes. Press materials claimed the product complied with National Collegiate Athletic Association (NCAA) guidelines. A closer look at the ingredients, however, revealed a compound called Citrus Aurantium (also known as Bitter Orange). This compound is similar to ephedrine, which is banned by the NCAA and the International Olympic Committee (IOC), and pseudoephedrine, which is banned by the IOC.* Yet, it is doubtful most athletes would make this connection. * The IOC identifies a positive test for pseudoephedrine as a concentration in urine greater than 25 micrograms per milliliter. Unfortunately this scenario is all too familiar, adding to the already growing concern that some ephedra-free products may be as harmful as those that actually contain the substance. While athletes continue to seek a competitive advantage via supplements, sports health professionals must know and educate players about the risks associated with ephedra-free products. After all, in light of the FDA's recent actions, they're bound to proliferate in an already flooded market. Still, many of the purported uses of these supplements lack solid research. Some supplements have the potential to interact poorly with certain medications and foods to produce potentially dangerous side effects. To help you help your athletes navigate the options during training and competition, here is a list of ingredients and effects to watch out for:1 Back to Top
 Manufacturers of ephedra‐free products also commonly combine stimulants with aspirin‐like substances in an attempt to mimic the "ECA Stack" (i.e., blend of ephedrine, caffeine and aspirin). But that can be risky. Some products contain more than the recommended limit of 300 mg of caffeine per serving. And, in some cases, more than three times that amount is suggested throughout the day.   Back to Top
With the plethora of new "ephedra-free" supplements on the market, athletes will no doubt be interested in using them in misguided attempts to improve performance. As responsible professionals, we can help athletes understand the pros and cons of taking "ephedra-free" supplements and be a resource for providing accurate and up-to-date information. Back to Top
• Reinforce the fact that dietary supplements are not regulated. Some manufacturers may use potentially unsafe ingredients and make inaccurate claims on labels. • Explain the lack of consistency in products. You can cite a recent study from the University of Minnesota in which researchers found that, of 92 Echinacea products reviewed, two-thirds did not meet expectations for recommended • Help athletes understand that "ephedra-free" may still contain banned ingredients, no matter how the products are marketed. This puts players at risk for being noncompliant with NCAA rules and other important guidelines. • Educate athletes on risky combinations, contraindications and potential side effects. Back to Top
Susan Kundrat, M.S., R.D., L.D., is the owner of Nutrition on the Move in Urbana, Ill., and the sports nutrition consultant for the Northwestern University Wildcats athletic teams in Evanston, Ill. References: 1 Natural Medicines Comprehensive Database: www.naturaldatabase.com 2 Archives of Internal Medicine, 2003;163:2290-2295 GSSI Sports Science News is designed to provide up-to-date information on current topics in sports nutrition and exercise science. For further information on this or other topics, please visit the Gatorade Sports Science Institute Web site at www.gssiweb.com or The Gatorade Company at www.gatorade.com. We also encourage you to register for your free online membership with GSSI to receive the latest research on sports science topics. In an effort to provide current and useful information via GSSI Sports Science News, comments and suggestions on this or future topics are highly valued and encouraged. Please email any feedback to gssi_update@fleishman.com. This message was sent to you from GSSI Sports Science News. To unsubscribe, click here. By unsubscribing, you are electing not to receive future GSSI Sports Science Newsletters. It could take up to two weeks to remove your name from the mailing list. If you would prefer to unsubscribe through Postal Mail, please send your request (including your email address) to: Gatorade Professional Marketing Email Series, 555 West Monroe St., Chicago, IL 60661. This information is current at time of publication.

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