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SIGMA-ALDRICH MATERIAL SAFETY DATA SHEET Date Printed: 09/04/2003 Date Updated: 12/19/2002 Version 1.5 Section 1 - Product and Company Information Product Name TETRACYCLINE HYDROCHLORIDE CRYSTALLINE Product Number T3383 Brand SIGMA Company Sigma-Aldrich Street Address 3050 Spruce Street City, State, Zip, Country SAINT LOUIS MO 63103 US Technical Phone: 314 771 5765 Emergency Phone: 414 273 3850 Ext. 5996 Fax: 800 325 5052 Section 2 - Composition/Information on Ingredient Substance Name CAS # SARA 313 TETRACYCLINE HYDROCHLORIDE 64-75-5 Yes Formula C22H24N2O8.ClH Synonyms Achromycin hydrochloride,ALA TET,Amycin, hydrochloride,Artomycin,Bristacycline, Cancycline-250,Cefracycline tablets, Chlorhydrate de tetracycline (French), Chlorowodorku tetracykliny (Polish),Cyclopar, Diacycine,Dumocyclin,Hostacycline,Medamycin, Mephacyclin,NCI-C55561,Neocycline B,Paltet, Panmycin hydrochloride,Partrex,Piracaps, Polycycline hydrochloride,Polyotic ointment, Qidtet,Quadracycline,Quatrex,Remicyclin,Ricycline, Ro-Cycline,Sanclomycine,Steclin,Stilciclina, Subamycin,Sumycin,Supramycin,Tefilin,Teline, Telotrex,Tet-Cy,Tetrabakat,Tetrabid,Tetrablet, Tetracaps,Tetrachel, Tetraciclina cloridrato (Italian),Tetracompren, Tetracycline chlorohydrate, Tetracycline hydrochloride,Tetra-D,Tetrakap, Tetralution,Tetramavan,Tetra-wedel,Tetrosol, Topicycline,Triphacyclin,U-5965,Unicin,Unimycin, Vetquamycin-324 RTECS Number: QI9100000 Section 3 - Hazards Identification EMERGENCY OVERVIEW Irritant.
Irritating to eyes, respiratory system and skin.
Photosensitizer. Calif. Prop. 65 reproductive hazard. Target organ(s): Liver. Teeth. Bones.
HMIS RATING HEALTH: 3* FLAMMABILITY: 0 REACTIVITY: 1 NFPA RATING HEALTH: 3 FLAMMABILITY: 0 REACTIVITY: 1 *additional chronic hazards present.
For additional information on toxicity, please refer to Section 11.
Section 4 - First Aid Measures ORAL EXPOSURE If swallowed, wash out mouth with water provided person is conscious. Call a physician.
INHALATION EXPOSURE If inhaled, remove to fresh air. If not breathing give artificial respiration. If breathing is difficult, give oxygen.
DERMAL EXPOSURE In case of contact, immediately wash skin with soap and copious amounts of water.
EYE EXPOSURE In case of contact, immediately flush eyes with copious amounts of water for at least 15 minutes.
Section 5 - Fire Fighting Measures FLASH POINT N/A AUTOIGNITION TEMP N/A FLAMMABILITY N/A EXTINGUISHING MEDIA Suitable: Water spray. Carbon dioxide, dry chemical powder, or appropriate foam.
FIREFIGHTING Protective Equipment: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes.
Specific Hazard(s): Emits toxic fumes under fire conditions.
Section 6 - Accidental Release Measures PROCEDURE(S) OF PERSONAL PRECAUTION(S) Wear respirator, chemical safety goggles, rubber boots, and heavy rubber gloves.
METHODS FOR CLEANING UP Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete.
Section 7 - Handling and Storage SIGMA - T3383 www.sigma-aldrich.com Page 2 HANDLING User Exposure: Do not breathe dust. Avoid contact with eyes, skin, and clothing. Avoid prolonged or repeated exposure.
STORAGE Suitable: Keep tightly closed.
Store at -20°C Section 8 - Exposure Controls / PPE ENGINEERING CONTROLS Safety shower and eye bath. Mechanical exhaust required.
PERSONAL PROTECTIVE EQUIPMENT Respiratory: Government approved respirator.
Hand: Compatible chemical-resistant gloves.
Eye: Chemical safety goggles.
GENERAL HYGIENE MEASURES Wash thoroughly after handling.
Section 9 - Physical/Chemical Properties Appearance Physical State: Solid Property Value At Temperature or Pressure Molecular Weight 480.91 AMU pH N/A BP/BP Range N/A MP/MP Range 220 - 223 °C Freezing Point N/A Vapor Pressure N/A Vapor Density N/A Saturated Vapor Conc. N/A Bulk Density N/A Odor Threshold N/A Volatile% N/A VOC Content N/A Water Content N/A Solvent Content N/A Evaporation Rate N/A Viscosity N/A Surface Tension N/A Partition Coefficient N/A Decomposition Temp. N/A Flash Point N/A Explosion Limits N/A Flammability N/A Autoignition Temp N/A Refractive Index N/A Optical Rotation N/A Miscellaneous Data N/A Solubility N/A N/A = not available Section 10 - Stability and Reactivity STABILITY Stable: Stable.
Conditions of Instability: May discolor on exposure to light.
SIGMA - T3383 www.sigma-aldrich.com Page 3 Materials to Avoid: Strong oxidizing agents.
HAZARDOUS DECOMPOSITION PRODUCTS Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide, Nitrogen oxides, Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION Hazardous Polymerization: Will not occur Section 11 - Toxicological Information ROUTE OF EXPOSURE Skin Contact: Causes skin irritation.
Skin Absorption: May be harmful if absorbed through the skin.
Eye Contact: Causes eye irritation.
Inhalation: Material is irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled.
Ingestion: May be harmful if swallowed.
SENSITIZATION Sensitization: Prolonged or repeated exposure may cause allergic reactions in certain sensitive individuals.
TARGET ORGAN(S) OR SYSTEM(S) Liver. Teeth. Bones.
SIGNS AND SYMPTOMS OF EXPOSURE Can cause phototoxic reactions, gastrointestinal disturbances, turn teeth yellow and reduce mineralization.
TOXICITY DATA Oral Rat 6443 mg/kg LD50 Intraperitoneal Rat 318 MG/KG LD50 Subcutaneous Rat 700 MG/KG LD50 Remarks: Gastrointestinal:Hypermotility, diarrhea.
Intravenous Rat 128 MG/KG LD50 Oral Mouse 2759 mg/kg LD50 Intraperitoneal Mouse 368 MG/KG LD50 SIGMA - T3383 www.sigma-aldrich.com Page 4 Intravenous Mouse 157 MG/KG LD50 CHRONIC EXPOSURE - CARCINOGEN Result: This product is or contains a component that is probably not carcinogenic based on its IARC, ACGIH, NTP, or EPA classification.
NTP CARCINOGEN LIST Rating: No evidence.
Species: Mouse/rat Route: Feed CHRONIC EXPOSURE - TERATOGEN Result: Possible risk of congenital malformation in the fetus.
Species: Rat Dose: 14 GM/KG Route of Application: Oral Exposure Time: (3D MALE/3D PRE-22D PREG) Result: Specific Developmental Abnormalities: Musculoskeletal system. Specific Developmental Abnormalities: Urogenital system.
Species: Rat Dose: 240 MG/KG Route of Application: Subcutaneous Exposure Time: (16-20D PREG) Result: Effects on Embryo or Fetus: Other effects to embryo.
Species: Rat Dose: 240 MG/KG Route of Application: Intramuscular Exposure Time: (10-15D PREG) Result: Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus).
Species: Mouse Dose: 600 MG/KG Route of Application: Intraperitoneal Exposure Time: (8-13D PREG) Result: Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus).
Species: Mouse Dose: 150 MG/KG Route of Application: Intraperitoneal Exposure Time: (10D PREG) Result: Specific Developmental Abnormalities: Musculoskeletal system.
Species: Mouse Dose: 2250 MG/KG Route of Application: Subcutaneous Exposure Time: (10-18D PREG) Result: Specific Developmental Abnormalities: Urogenital system.
Effects on Newborn: Viability index (e.g., # alive at day 4 per # born alive). Effects on Newborn: Growth statistics (e.g., reduced weight gain).
SIGMA - T3383 www.sigma-aldrich.com Page 5 CHRONIC EXPOSURE - MUTAGEN Species: Human Dose: 500 UMOL/L Cell Type: fibroblast Mutation test: DNA damage Species: Human Dose: 750 UMOL/L Cell Type: fibroblast Mutation test: Unscheduled DNA synthesis Species: Human Dose: 1250 UMOL/L Cell Type: fibroblast Mutation test: DNA inhibition Species: Rat Dose: 200 UMOL/L Cell Type: liver Mutation test: DNA damage Species: Mouse Dose: 31600 UG/L Cell Type: mammary gland Mutation test: DNA inhibition Species: Mouse Dose: 31600 UG/L Cell Type: mammary gland Mutation test: Other mutation test systems Species: Mouse Dose: 31600 UG/L Exposure Time: 24H Cell Type: mammary gland Mutation test: Cytogenetic analysis Species: Mouse Dose: 120 MG/L Cell Type: lymphocyte Mutation test: Mutation in mammalian somatic cells.
Species: Mouse Dose: 100 MG/L Cell Type: mammary gland Mutation test: Mutation in mammalian somatic cells.
Species: Hamster Dose: 3 MG/L Cell Type: Embryo Mutation test: Sister chromatid exchange CHRONIC EXPOSURE - REPRODUCTIVE HAZARD Species: Rat Dose: 6 GM/KG Route of Application: Oral Exposure Time: (9-14D PREG) Result: Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants).
SIGMA - T3383 www.sigma-aldrich.com Page 6 Species: Rat Dose: 425 MG/KG Route of Application: Intraperitoneal Exposure Time: (14-18D PREG) Result: Effects on Fertility: Abortion. Effects on Embryo or Fetus: Extra embryonic structures (e.g., placenta, umbilical cord).
Species: Rat Dose: 450 MG/KG Route of Application: Unreported Exposure Time: (7-15D PREG) Result: Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus).
Species: Rat Dose: 765 MG/KG Route of Application: Unreported Exposure Time: (7-15D PREG) Result: Effects on Fertility: Abortion.
Species: Rat Dose: 100 MG/KG Route of Application: Intrauterine Exposure Time: (1D PRE) Result: Maternal Effects: Uterus, cervix, vagina.
Species: Mouse Dose: 900 MG/KG Route of Application: Intraperitoneal Exposure Time: (8-13D PREG) Result: Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants).
Effects on Embryo or Fetus: Fetal death. Specific Developmental Abnormalities: Musculoskeletal system.
Species: Mouse Dose: 750 MG/KG Route of Application: Subcutaneous Exposure Time: (1-6D PREG) Result: Effects on Fertility: Abortion.
Species: Mouse Dose: 2250 MG/KG Route of Application: Parenteral Exposure Time: (10-18D PREG) Result: Effects on Newborn: Growth statistics (e.g., reduced weight gain).
Species: Rabbit Dose: 9 GM/KG Route of Application: Oral Exposure Time: (8-16D PREG) Result: Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of implants).
Section 12 - Ecological Information No data available.
SIGMA - T3383 www.sigma-aldrich.com Page 7 Section 13 - Disposal Considerations APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local environmental regulations.
Section 14 - Transport Information DOT Proper Shipping Name: None Non-Hazardous for Transport: This substance is considered to be non-hazardous for transport.
IATA Non-Hazardous for Air Transport: Non-hazardous for air transport.
Section 15 - Regulatory Information EU ADDITIONAL CLASSIFICATION Symbol of Danger: Xi Indication of Danger: Irritant.
R: 36/37/38 Risk Statements: Irritating to eyes, respiratory system and skin.
S: 26 36 Safety Statements: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.
US CLASSIFICATION AND LABEL TEXT Indication of Danger: Irritant.
Risk Statements: Irritating to eyes, respiratory system and skin.
Safety Statements: In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Wear suitable protective clothing.
US Statements: Photosensitizer. Calif. Prop. 65 reproductive hazard. Target organ(s): Liver. Teeth. Bones.
UNITED STATES REGULATORY INFORMATION SARA LISTED: Yes DEMINIMIS: 1 % NOTES: This product is subject to SARA section 313 reporting requirements.
TSCA INVENTORY ITEM: Yes UNITED STATES - STATE REGULATORY INFORMATION CALIFORNIA PROP - 65 California Prop - 65: This product is or contains chemical(s) known to the state of California to cause developmental toxicity.
CANADA REGULATORY INFORMATION WHMIS Classification: This product has been classified in accordance with the hazard criteria of the CPR, and the MSDS contains all the information required by the CPR.
DSL: Yes NDSL: No SIGMA - T3383 www.sigma-aldrich.com Page 8 Section 16 - Other Information DISCLAIMER For R&D use only. Not for drug, household or other uses.
WARRANTY The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide.
Sigma-Aldrich Inc., shall not be held liable for any damage resulting from handling or from contact with the above product.
See reverse side of invoice or packing slip for additional terms and conditions of sale. Copyright 2003 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only.
SIGMA - T3383 www.sigma-aldrich.com Page 9

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