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Wadie B. S., Badawi A.M.*, Ghoneim M. A.
Mansoura Urology & Nephrology Center, Mansoura University, Mansoura, Egypt
* Biomedical Engineering dept., Faculty of Engineering, Cairo University
Abstract: INTRODUCTION: I-PSS is to be the prototype of symptom scores,
which are exclusively used in the evaluation of porstatic patients and
follow up of different treatment modalities. Many studies demonstrated
poor or no correlation between BOO as diagnosed by pressure flow study
and symptom severity as projected by I-PSS. This is the reason we tried
the application of Artificial Neural Network (ANN) model in the
evaluation patients with LUTS. PATIENTS AND METHODS: 460
patients were prospectively enrolled in this study, all of them had I-PSS,
free flow PSA, TRUS and pressure flow plotting. ANN model (Prostatic
Obstruction Predictor; POP) was designed. RESULTS: In the training set
(305 patients), the model can predict obstruction in 94% (sensitivity of 94
% and specificity of 68 %). While in the test set (155), the model could
predict obstruction in 87% of cases (sensitivity of 87% and specificity of
DISCUSSION: ANN is a relatively new modality in urologic diagnosis.
Similar models were used in differentiation between benign and
malignant prostatic enlargement as well in the diagnosis of prostatic
adenocarcinoma. The accuracy of the model in the diagnosis of
obstruction based on I-PSS is accepted, considering that statistical models
failed to demonstrate more than poor correlation between symptoms and
objective obstruction. CONCLUSION: POP is an ANN model that helps
in solving the conflict between symptoms and BOO; as objectively
I-PSS is a symptom score based on the AUA symptom index 1, which is
designed for evaluation of males with LUTS due to benign prostatic
Many studies relied on I-PSS as an objective tool used in the evaluation
of patients with BPH and in the follow up after different treatment
Many studies failed to demonstrate a significant correlation between I-
PSS and obstruction; as diagnosed by pressure flow studies 5, 6
The use of Artificial Neural Network (ANN) was tried in the evaluation
of patients with LUTS, aiming at optimizing the use of symptom scores.
Between 1997 and 1999, 520 patients were prospectively included in a
protocol designed to evaluate the correlation of prostate symptom score
with different objective parameters used in the evaluation of prostatic
Inclusion criteria are : males aged 45 years or more, having a total I-PSS
score of 7 or more, and not being treated for BPH before.
Men with indwelling urethral catheter, associated urerthral stricture or
bladder pathology i.e. malignancy or stone, as well as associated
neuropathic bladder or major neurologic disease e.g. stroke, were
All patients had complete clinical examination, including DRE, and a
neuro-urologic examination, serum total PSA, free flow rate, TRUS;
sextant biopsy was done only if total PSA is over 4 ng/ml, the DRE is
suspicious or the TRUS reveals suspicious nodules.
Out-patient cystoscopy, invasive urodynamic testing ( in the form of
filling and voiding water cystometry) are routinely carried out.
The clinical examination included the DRE and the sensations in the
saddle area, the anal tone and the bulbocavernosus reflex.
Serum PSA is requested. The test was done using the IMx technique
Free flow was carried out using a rotating drum flowmeter (Urodyn 1000,
Dantec, Denmark). Only averaged value of three separate readings was
Outpatient cystoscopy was carried out under local anaethesia (20 ml of 2
% Lidocaine gel instillation), using 17 F. rigid cystoscope.
The urethra was examined for strictures, the prostate for the type and
degree of enlargement and the bladder for associated pathology.
Urodynamic testing was carried out using a multichannel computerized
Examination data are stored as database files, with a modification of the
Filing water cystometry was done using 8 F. dual urodynamic catheter
with terminal hole and one side hole (Porges, France).
The initial part of the test was measurement of the post –voiding residua
urine (PVR); measured within 5 minutes of the patient’s last free void;
Rate of filling is 50 ml/min, sometimes increased to 100 ml/min, if there
is an evidence of low amplitude uninhibited contractions.
This is followed by voiding cystometry in erect position, with the
Technique and specifications of the urodynamic testing was conforming
Results are filtered and saved with interpretation of the pressure flow
pattern with the use of the linear Passive Urethral Resistance Relation
Grades 0 and 1 are considered non- obstructed, grade 2 is equivocal and
grades 3,4,5and 6 are considered obstructed in ascending manner9
On the same day of the urodynamic testing, the patient was asked to
answer a standardized, validated Arabic form of the I-PSS questionnaire.
Four hundred and sixty patients were evaluable.
Data of the patients were fed to an ANN specially designed to accomplish
this task, using MATLAB software (Mathworks, USA).
ANN is a complex computational system capable of undertaking a large
In doing so, it mimics the functions of the human brain, hence the name “
A Multilayer Perceptron (MLP), in its simplest description, is a network
consisting of series of processing elements (neurons) arranged in layers.
Each of these neurons is capable of simple computational processes, data
are being presented in the back –propagation model to different neurons
for a large number of times (epochs or iterations) 10
In the POP model, a back propagation MLP is established
Unsupervised learning, using the K- means and fuzzy logic principles
This is followed by back propagation supervised learning.
662,000 iterations were needed to develop a model that has the lowest
The network consists of 8 neurons in the input layer, 25 neurons in the
hidden layer and 3 neurons in the output layer.
Figure 1 shows the arbitrary description of a back propagation MLP
Training set consists of the records of 305 patients and the testing set
consists of the records of 155 patients.
According to the symptom severity, 38 patients (8.3%) were found to
have mild symptoms, 241 (52.4%) moderate symptoms and 180 (39.1%)
The mean values for the patients’ answers of the individual questions are
The mean value of the individual question scores range from 2.03 to 3.03
and the mean value of the quality of life index is 4.4 “Unhappy”
The mean value of the total score as well as the voiding (obstructive)
score (the sum of questions 1,3,5,and 6) and the storage (irritative) score
(the sum of questions 2, 4 and 7) are demonstrated in table 1.
The output of the model is classified into obstructed, equivocal and non-
Although the original pressure flow analysis was interpreted in terms of
LinPURR, which is a seven-band nomogram, yet, for simplicity, a
categorical classification of the nomogram was used (grades 0 and 1 are
non- obstructed, grade 2 is equivocal and grades 3, 4, 5, and 6 are
The overall number of patients having Schafer grade of 3 or more is 285
(60%), grade 2 (considered to be equivocal) is 88 (18%), and grade 0 and
1 are 85 (22%). Table 2 demonstrates the distribution of different grades
of obstruction among the training and testing groups.
In the training set, the sensitivity and specificity of the model to predict
Sensitivity and specificity to predict non-obstruction are 68% and 85%;
sensitivity and specificity to predict equivocal cases are 56% and 86%
Mean sensitivity of the model in training set is 72.7% and specificity is
Table 3 shows the confusion matrix of the training set
While in the test set, the sensitivity and specificity of the model to predict
obstruction are 87% and 40%, sensitivity and specificity to predict non-
obstruction are 60% and 82%, sensitivity and specificity to predict
equivocal cases are 49% and 83% respectively.
Mean sensitivity of the model in testing set is 65.3% and specificity is
Confusion matrix of this group is demonstrated in table 4
Although it is used by many urologists to evaluate treatment outcome of
BPH, I-PSS did not correlate to objective parameters customarily used in
To date, the gold standard of the diagnosis of BOO is pressure flow
Based on conventional statistics, it was demonstrated that correlation
between I-PSS and BOO as diagnosed by pressure flow studies, is
The method of LinPURR was considered the standard for analysis of the
pressure flow plots, as it is considered more sensitive than other available
methods in the quantification of obstruction.15
Besides, the size of the equivocal zone (grade II) is comparable to the ICS
method, which is smaller than other comparable nomograms 9
In an earlier report, statistical analysis revealed no correlation between
the severity of symptoms and BOO, as rated by pressure flow study.
This is the rational behind using ANN to verify if there could be an
improvement in diagnostic yield of the I-PSS.
In the POP model, a back pro pagation MLP is established
In medicine, ANN was exclusively used in decision-making and
classification systems in different fields.
Fuzzy logic was used to differentiate between cirrhotic liver and normal
or fatty. An eight dimensional vector was fed to this model and the output
In urology, the diagnosis and prognostication of prostatic
adenocarcinoma had a considerable share of ANN applications17 18
One of the well-known applications of ANN, the ProstAsure Index (PI),
In the original paper, Stamey et al described a MLP model capable of
differentiating benign from malignant prostate with a sensitivity of 815
The index depends on 4 input parameters (patient’s age, serum PSA,
prostatic acid phosphatase, and total creatine kinase)
The output consists of a mathematical scale; 0 or less, 0.1-0.5, 0.5-1 and 1
or more which correspond to normal, BPH, suspicious of malignancy and
Our results demonstrate that, using ANN, I-PSS could be used in the
diagnosis of BOO with an overall sensitivity of 65% and a specificity of
The lowest sensitivity is encountered with equivocal cases.
Among our patients, 19% are classified by the LinPURR to be
Since all pressure flow nomogram have an equivocal zone 9, 12, this may
explain the relatively low overall sensitivity of the model, as the
sensitivity in the equivocal zone is only 49%.
Compared to ordinary statistical regression models, the POP model is a
step forward in the way to diagnose BOO based on symptom scores.
POP model is a helpful tool in objectifying non-nominal symptom score.
The utilization of the ANN’s ability of making decision boundaries from
nonlinear data has made possible the evolution of a fairly reliable
The architecture of a back-propagation MLP model
A simple back-propagation neural network
Mean value of the score of individual questions
Mean score +/- Standard
*Sum of questions1, 3, 5&6, total is 20 § Sum of questions 2,4 &7, total is 15
Number of cases
The distribution of different LinPURR grades among training and
Obstruction ( determined by urodynamics)
Obstruction (projected by the POP)
Training set, Confusion matrix %
Obstruction ( determined by urodynamics)
Obstruction (projected by POP)
Testing set, confusion matrix %
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CURRICULUM VITAE SILVIA LUCIA CUFFINI EDUCACIÓN B.Sc. University of Córdoba. Argentine. 1989 Ph.D. University of Córdoba. Argentine. 1994 POSITIONS -CONICET – Full-time Researcher (since 1997) -Responsible Researcher of X-Ray Diffraction Sector-Radiation Laboratory CEPROCOR (Technological Center of Cordoba) (2000-2010) -Visited Professor in Universidade Federal de Santa C