International Journal of Obstetric Anesthesia (2005) 14, 147–158Ó 2004 Elsevier Ltd. All rights reserved. doi:10.1016/j.ijoa.2004.09.008
The National Institute of Clinical Excellence (NICE) guide-lines for caesarean sections: implications for the anaesthetist
Department of Anaesthesia, Poole Hospital, Dorset, Department of Obstetrics and Gynaecology,Princess Anne Hospital, Southampton, Department of Anaesthesia, St. Thomas’s Hospital, London, UK
INTRODUCTIONThe bodies involved; Background; Aims of the guidelines; Evidence and grading of recommendationsSUMMARY OF RECOMMENDATIONS AFFECTING ANAESTHETIC PRACTICEProvision of information and consentClassification of urgency of caesarean sectionPlanned caesarean sectionFactors in intrapartum care affecting likelihood of caesarean sectionFactors with no influence on caesarean section rates: Epidural analgesia; Eating in labourProcedural aspects of caesarean section: Decision-to-delivery interval for emergency caesarean section; Pre-
operative testing and preparation for caesarean section; Urinary catheterisation at caesarean section
Aspects of anaesthesia for caesarean section: Antacids and antiemetics; General versus regional anaesthesia for
caesarean section; Converting epidural analgesia to anaesthesia for caesarean section; Place of induc-tion and monitoring during caesarean section; Procedures to avoid hypotension; Failed intubation
Surgical techniques for caesarean section of relevance to the anaesthetist: Use of uterotonics; Uterine exteriorisation;
Use of antibiotics; Thromboprophylaxis for caesarean section
Care of the baby born by caesarean sectionCare of the woman after caesarean section: High dependency and intensive care admission; Routine monitoring after
Pain management after caesarean section: Intrathecal and epidural analgesia; Patient controlled analgesia (PCA)
and non-steroidal anti-inflammatory analgesics; Other local anaesthetic techniques
Post partum care: Early eating and drinking after caesarean section; Urinary catheter removal after caesarean
Keywords: NICE guidelines; Caesarean section; Anaesthesia
M.Y.K. Wee, Consultant Obstetric Anaesthetist, Department ofAnaesthesia, Poole Hospital NHS Trust, Longfleet Road, Poole, Dorset
The National Institute for Clinical Excellence (NICE)
BH 15 2JB, UK, H. Brown, Senior Specialist Registrar in Obstetrics
is part of the National Health Service (NHS) in the
and Gynaecology, Princess Anne Hospital, Coxford Road,
UK. It was established in 1999 as an independent
Southampton SO16 5YA, F. Reynolds, Emeritus Professor ofObstetric Anaesthesia, St. Thomas’s Hospital, Lambeth Palace Road,
organisation to promote clinical excellence by provid-
ing guidance on treatments and care based on the
Correspondence to: M.Y.K Wee, Consultant Obstetric Anaesthetist,
best available evidence and effective use of resources.
Department of Anaesthesia, Poole Hospital NHS Trust, Longfleet
NICE has under its wing the Confidential Enquiries
Road, Poole, Dorset BH 15 2JB, UK, Tel.: +44 120 244 2443;
into Maternal and Child Health (CEMACH). In April
2004, NICE published caesarean section guidelines;
International Journal of Obstetric Anesthesia
the aim of this review is to highlight aspects of these
the UK according to ethnicity, with higher rates reported
guidelines that may have implications for anaes-
in black African and Caribbean ethnic groups.
The five major indications for caesarean section in
Several versions of the guidelines are available and
the UK are fetal compromise (22%), Ôfailure to progress’
in labour (20%), repeat caesarean section (14%), breech
presentation (11%) and maternal request (7%).The first
indication is influenced by the use of continuous elec-
tronic fetal monitoring, which may be associated with
increased caesarean section rate unless it is used in con-
junction with fetal blood sampling to assess fetal acid-
base balance before a decision is made for caesarean
The guidelines aim to provide evidence-based informa-
Risks and benefits of caesarean section Certain specific indications for caesarean section Effective management strategies to avoid caesarean
The National Collaborating Centre for Women’s and
Anaesthetic and surgical aspects of care
Children’s Health (NCC-WCH) was commissioned by
Interventions to reduce morbidity from caesarean sec-
NICE to produce the guidelines. NICE and 60 registered
stakeholders including the Royal College of Anaesthe-
Aspects of organisation and environment that affect
tists (RCA) and Obstetric Anaesthetists’ Association
(OAA) were involved in their development. An indepen-
This does not cover all the clinical decisions and care
dent Guideline Review Panel and Patient Involvement
pathways that may lead to caesarean section. For exam-
Unit then reviewed the draft guidelines.
ple, it omits advice on the risks and benefits of caesarean
The NCC-WCH established the Guideline Develop-
section in specific conditions such as preeclampsia or
ment Group (GDG) comprising a general practitioner
gestational diabetes or in rare diseases.
who chaired the group, two obstetricians, two midwives,
As well as clinical effectiveness, the guidelines were
a neonatologist, an anaesthetist and two consumers.
concerned with cost-effectiveness of caesarean section
Other members of the GDG included the director of
the NCC-WCH, chair of CEMACH, informatics special-ist, health economist and several research fellows. Theanaesthetic representative was selected from nomina-
tions submitted by the RCA and the OAA and consulted
Evidence from studies that were least subject to bias and
widely during development of the guidelines on issues
published systematic reviews or meta-analyses were
of anaesthetic interest from obstetric anaesthetist experts
used where available (Data are presented as
absolute risks, relative risks or odds ratios where rele-vant. Where data are statistically significant they arealso presented as numbers needed to treat for beneficial
outcomes or numbers needed to harm for adverse effects
as relevant. Recommendations are graded according to
(NSCSA) reported that in England and Wales, caesarean
the strength of the evidence that supports them
section rates increased from 9% of deliveries in 1980 to
21% in 2001, with similar increases in many developedcountries.The average age of women giving birth has
increased and caesarean section rates increase with
maternal age. The caesarean section rate for women intheir first pregnancy is now 24% and for women who
Bullet-points below quote from, summarise or para-
have had a previous caesarean section, it is markedly in-
phrase recommendations from the guidelines; the letter
creased (67%). The caesarean section rate also varied in
The National Institute of Clinical Excellence (NICE) guidelines for caesarean sections
Systematic review or meta-analyses of randomised controlled trials
At least one well-designed controlled study without randomisation
At least one well-designed quasi-experimental study, such as a cohort study
Well-designed non-experimental descriptive studies, such as comparative studies,
correlation studies, case controlled studies and case series
Expert committee reports, or opinions and/or clinical experience of respected authorities
Based on level 2 evidence or extrapolated from level 1 evidence
Based on level 3 evidence or extrapolated from level 1 or 2 evidence
Based on level 4 evidence or extrapolated from level 1, 2 or 3 evidence
Group practice point based on the view of the guideline development group
Recommendation taken from NICE Technology Appraisal
of caesarean section, such estimates should be derivedfrom intention to treat analysis of RCTs and systematic
Pregnant women should be given evidence-based
reviews comparing planned caesarean section with
information and support to enable them to make
planned vaginal birth.Anaesthetists should give full
information including the material risks of anaesthesia
Information about caesarean section should be given
during the antenatal period because about 1 in 5 preg-
Consent for caesarean section should be requested
nant women will have a caesarean section. [GPP]
after providing the pregnant woman with evi-
The information should be in a form that is accessi-
dence-based information and in a manner that
ble Á Á Á taking into account cultural needs of ethnic
respects the woman’s dignity, privacy, views and
minority communities Á Á Á and those with disabilities.
culture whilst taking into consideration the clinical
In 1993, the Expert Maternity Group from the
A competent pregnant woman is entitled to refuse
Department of Health released the report Changing
treatment Á Á Á even when the treatment would clearly
Childbwhich made explicit the right of women
benefit her or her baby’s health. Refusal of treatment
to be involved in decisions regarding all aspects of
needs to be one of the woman’s options. [D]
their care during pregnancy and childbirth. In orderto discuss decisions with caregivers, women requireevidence-based information. Randomised trials (RCTs)
Classification of urgency of caesarean section
on antenatal education suggest that the provision ofinformation is often seen as inadequate by women.
Caesarean section has traditionally been classified as
The use of evidence-based information leaflets has
elective and emergency. The Ôemergency’ category,
been shown to improve maternal satisfaction.As
however, does not differentiate between true emergen-
about one in five women in the UK are delivered by
cies where the life of the woman or fetus is threatened,
caesarean section (the majority unplanned),all of
and situations in which there is no imminent threat to
them need information on both vaginal and caesarean
life. A four-point classification has been piloted, used
delivery. The Obstetric Anaesthetists’ Association has
in a national survey and shown to predict baby out-
produced evidence-based leaflets and a related video
come.Its adoption is recommended to aid clear com-
on anaesthesia for caesarean section that can be used
munication between healthcare professionals about the
Provision of information is a prerequisite to consent
Category 1: immediate threat to the life of the woman or
and should cover the patient’s condition, possible inves-
fetus. This includes caesarean section for acute severe
tigations and treatment options, their risks and benefits
fetal bradycardia, cord prolapse, uterine rupture, fetal
and the risk of refusing treIdeally, in the case
International Journal of Obstetric Anesthesia
Category 2: maternal or fetal compromise that is not
Consultant obstetricians should be involved in the
immediately life-threatening. There is a degree of
decision-makingÁ Á Á because this reduces the likeli-
urgency to deliver the baby in order to prevent further
deterioration of either the mother’s or the baby’s con-
Electronic fetal monitoring is associated with an
dition. Examples include antepartum haemorrhage
increased likelihood of caesarean section. When cae-
and failure to progress in labour with maternal or
sarean section is contemplated because of an abnor-
mal fetal heart rate pattern Á Á Á Á Á Á fetal blood
Category 3: no maternal or fetal compromise but needs
sampling should be offered if possible. [B]
early delivery. Examples include a situation in whichcaesarean section is planned but the woman is admit-ted in early labour or with ruptured membranes.
Factors with no influence on caesarean section
Category 4: delivery timed to suit woman or staff. This
includes all planned elective caesarean sections.
A woman who mistakenly believes that epidural anal-
gesia increases the likelihood of caesarean section will
The guidelines recommend that planned caesarean sec-
be prejudiced against it. Fortunately there is ample
with breech presentation at term if external cephalic
meta-analyses ) that epidural analgesia during
version has been unsuccessful or is contraindicated
labour does not influence the likelihood of caesarean
to HIV-positive women at term [A].
Aspects of care in labour with no influence on the
to women with grade 3 or 4 placenta praevia [D]
likelihood of caesarean section include walking,
The evidence for other indications is less sound, for
non-supine position during the second stage, immer-
example it is uncertain whether caesarean section
sion in water, epidural analgesia and raspberry leaf
confers any additional benefit in twin pregnancies
at term where the first twin is cephalic, pretermbabies or small for gestational age babies.
Maternal request is not on its own considered an
indication for caesarean section. Whether an indi-
Eating in labour is an issue much debated between
vidual clinician has the right to decline a request
healthcare professionals, some midwives believing it
for a caesarean section is of concern to anaesthe-
will reduce the need for intervention. The debate is rel-
tists. Individual women may request caesarean sec-
evant to obstetric anaesthesia. One RCT comparing a
tion because of fear of pain in childbirth. The
group given a light diet in labour with a starved group
guideline recommends counselling for this, but the
given water only (the guidelines erroneously state that
logical inference that a discussion with an anaesthe-
the starved group were given water, tea, coffee or co-
tist about epidural analgesia could form part of this
coa), showed that while maternal ketosis was improved,
gastric volume and vomiting were both increased by eat-ing.Another RCT substituted an isotonic sport drinkfor solids and showed that it reduced ketosis without
Factors in intrapartum care affecting likelihood of
increasing gastric Neither study was powered
to examine obstetric outcome, which is the subject of an
The indications for emergency caesarean section should
on-going study. The recommendation in the guidelines
surely feature prominently in the guidelines, as one of
the aims is to provide effective management strategies
Women should be informed that eating a low residue
to avoid caesarean section, and the majority of caesar-
diet during labourÁ Á Á results in larger gastric volumes,
ean sections are unplanned. Yet this topic is addressed
but the effect on the risk of aspiration if anaesthesia is
only under the heading Factors reducing the likelihood
required is uncertainÁ Á Á having isotonic drinks during
of (caesarean section). The recommendations related
labour prevents ketosis without a concomitant
A partogram with a 4-h action line should be used to
This surely misses the point; we know larger gastric
monitor progress in women in spontaneous labour with
volumes are associated with increased likelihood of
an uncomplicated singleton pregnancy at term, because
vomiting, but not whether calorie intake affects the pro-
it reduces the likelihood of caesarean section. [A]
The National Institute of Clinical Excellence (NICE) guidelines for caesarean sections
Women having caesarean section for antepartum
haemorrhage, placenta abruption, uterine rupture
Decision-to-delivery interval for emergency caesarean
and placenta praevia are at increased risk of blood
loss >1000 mL and should be delivered at a maternity
Earlier guidelines on electronic fetal heart monitoring
unit with on-site blood transfusion services. [C]
recommended that where acute fetal compromise was
Grouping and saving of serum, cross-matching and a
suspected, delivery should occur as soon as possible,
clotting screen are unnecessary before caesarean sec-
ideally within 30 min, taking into account fetal and
maternal factorResearch to underpin this 30-minrule is limited.Poor outcome among babies deliv-
Urinary catheterisation at caesarean section
ered rapidly prompted the misapprehension that rapiddelivery may itself be causative, overlooking the fact
A survey of UK obstetricians reported that for caesarean
that the most compromised babies are commonly deliv-
section under regional anaesthesia the majority (82%)
ered with the least delay.However, general anaes-
use an indwelling urinary catheter for both the procedure
thesia to allow rapid delivery has been a cause of
and postoperatively, with a minority using the catheter
for the procedure only or an in-out cathet
The association between decision-to-delivery interval
Women having caesarean section with regional
and neonatal and maternal outcomes was examined
anaesthesia require an indwelling urinary catheter to
using data from NSCSA.Babies who were delivered
prevent over-distension of the bladder because the
with short (<30 min) or long (>75 min) decision-to-de-
anaesthetic block interferes with normal bladder
livery intervals were more likely to require special care.
These findings are consistent with previous studies.A delay of more than 75 min, particularly of course in
Aspects of anaesthesia for caesarean section
the presence of fetal or maternal compromise, is associ-ated with poorer outcomes.
The options for anaesthesia and analgesia should be dis-
The guidelines suggest that although 30 min is an
cussed with the woman before her caesarean section using
arbitrary limit, it remains important that the obstetric
obstetric anaesthesia and analgesia information media.
team can respond safely within this time to Category1 caesarean section. The 75-min decision-to-delivery
time should be added as a clinically important stan-dard. [C]
Aspiration pneumonitis is now a rare event associatedwith general anaesthesia for caesarean section. In theUK 99% of units routinely use drugs to reduce the
Pre-operative testing and preparation for caesarean
gastric volume and acidity for elective caesarean sec-
tion and 98% for emergency caesarean sect99%use H2 receptor blockers (ranitidine, cimetidine), 2%
Women who are anaemic are less able to tolerate blood
proton pump inhibitors (omeprazole) and 99% non-
Recommendations for antenatal screening in-
particulate antacid (sodium citrate). RCTs have shown
clude measuring haemoglobin at booking and at 28
that sodium citrate reduces acidity without affecting
gastric that ranitidine combined with sodium
It has been estimated that, of all women giving birth,
citrate reduces gastric volume and increases that
1.3% have blood loss >1000 mL while 0.7% have blood
omeprazole also reduces the risk of aspiration
loss >1500 mL.Haemorrhage remains an important
and that omeprazole results in higher mean pH than
cause of maternal mortaAlthough caesarean section
ranitidine, although ranitidine with sodium citrate is
in labour is associated with greater blood loss than vaginal
or planned caesarean deliverthere may be little differ-
Nausea and vomiting may be provoked by hypoten-
ence in blood loss between planned caesarean section and
sion during regional anaesthesia for caesarean section.
planned vaginal birth,while factors such as placental
Treatment of the cause will alleviate the symptom. Var-
abruption or antepartum haemorrhage contribute. Women
ious RCTs and a meta-analysis showed reduced nausea
who have caesarean section for antepartum haemorrhage,
and vomiting with metoclopramide, propofol, droperidol
placenta praevia or uterine rupture account for 21% of
and ondansetron in women having caesarean section un-
Women should be offered a haemoglobin assessment
pressure and metoclopramide were equally effective in
before caesarean section to identify those who have
this context.Ondansetron appears to be more effective
than metoclopramide but the latter is cheaper, while
International Journal of Obstetric Anesthesia
ondansetron is not advised for use during pregnancy and
caine alone, 2% lidocaine plus epinephrine and a mix-
ture of the two found no difference between the
To reduce the risk of aspiration pneumonitis, women
groups in time to adequate block.Another found that
should be offered drugs to reduce gastric volume and
the addition of bicarbonate accelerated the onset of 2%
lidocaine plus epinephrine and fentanyl.
To reduce the incidence of nausea and vomiting, women
having caesarean section should be offered antiemetics(either pharmacological or acupressure). [A]
Place of induction and monitoring during caesareansection
General versus regional anaesthesia for caesarean
One non-obstetric RCT comparing induction in the oper-
ating theatre with that in an anaesthetic room showed no
Regional anaesthesia is reportedly used in 77% of
difference in patient anxiety between the two groups
emergency and 91% of elective caesarean sect
A survey of 115 women having elective caesarean sec-
In category 1 caesarean sections, general anaesthesia
tion under regional anaesthesia reported that stress was
was used in 41%, regional anaesthesia in 54% and
related to anxiety about pain and the baby rather than
to the environment.The controversy relating to top-
anaesthesia in 3%. A UK survey of anaesthetic tech-
ping up other than in the environs of the operating the-
niques for caesarean section reported an overall fail-
atre was not addressed. The recommendations state:
For caesarean section under regional block continu-
combined spinal epidural 2% and for single-shot
ous pulse oximetry, non-invasive blood pressure
spinal anaesthetic 1.9%. Failure of regional anaesthe-
capable of one-minute cycles and electrocardiogra-
sia accounted for 10% of general anaesthetics for cae-
phy are recommended; for general anaesthesia there
should be full monitoring as recommended in the
The guidelines cite three RCTs comparing the effect
national guidelinesThe fetal heart rate should
of general versus regional anaesthesia for elective caesar-
be recorded during the initiation of regional block
ean section on maternal and neonatal morAt
and until the abdominal skin preparation is begun in
least three more were published in 2003. The document
asserts that no difference in neonatal outcomes was
Regional anaesthesia for caesarean section should be
detected between general and regional anaesthesia
induced in theatre because this does not increase
groups, and overlooks the adverse effect that spinal as
opposed to general or epidural anaesthesia may have
They do not mention that the important fact that this
allows continuous monitoring throughout induction and
General anaesthesia has commonly been found to re-
sult in increased blood loss.The same applies to cae-sarean section for placenta praevia.The authors cite
one RCT comparing general with regional anaesthesiafor severe preeclampsia, which found little difference
Lateral tilt of the operating table is standard practice
in maternal and/or fetal complications.
in the UK for the prevention of hypotension caused
by aortocaval compresA systematic review of
Women Á Á Á should be offered regional anaesthesia
three early studies, and one more recent one found
because it is safer and results in less maternal and
no differences in Apgar scores or umbilical artery
neonatal morbidity than general anaesthesia. This
pH with lateral tilt,which is odd because early
includes women who have a diagnosis of placenta
studies certainly detected a benefit. Another RCT
comparing lateral with no tilt at emergency caesarean
This may be misleading in relation to spinal anaesthe-
section found no differences in maternal or neonatal
outcomes.Two RCTs comparing the effect of thefull lateral position (described incorrectly as laternal
Converting epidural analgesia to anaesthesia for
tilt) versus 15° wedge found no difference in inci-
dence of hypotension between the methods.A sys-tematic review that included 20 RCTs reported that
Conversion of an analgesic epidural to one suitable for
the following interventions reduce the incidence of
anaesthesia in the shortest time possible is desirable in
hypotension under spinal anaesthesia for caesarean
category 1 and 2 caesarean sections because this avoids
section: pre-load with crystalloid 20 mL/kg versus
general anaesthesia. One RCT comparing 0.5% bupiva-
control, pre-emptive colloid versus crystalloid, ephe-
The National Institute of Clinical Excellence (NICE) guidelines for caesarean sections
drine versus control and lower limb compression ver-
sus control.No differences in maternal or neonatalside effects were reported. The use of crystalloid has
Only a minority of obstetricians in the UK exteriorise
been shown by systematic review to be inconsistent
the uterus.One RCT found that uterine exteriorisa-
in its ability to prevent maternal hypotension [see
tion did not increase nausea, vomiting, sensation of
tugging or pain scores,although two women in
The guidelines recommend the use of phenyl-
the exteriorised group had their epidurals converted
to general anaesthesia because of pain. This has
equally effective as vasopressors, but fail to mention
implications for the anaesthetist as supplementary
that mothers given phenylephrine may have fewer
analgesia or conversion to general anaesthesia may
episodes of nausea and vomiting and that their babies
be needed and there may be medico-legal implica-
are less likely to be acidotic.The recommenda-
tions. No surgical advantage has been found for the
The operating table for caesarean section should have
Exteriorisation of the uterus is not recommended
a lateral tilt of 15° because this reduces maternal
because it is associated with more pain and does
not improve operative outcomes such as haemorrhage
Intravenous ephedrine or phenylephrine should be
used in the management of hypotension during cae-sarean section. [A]
Prophylactic antibiotics reduce the incidence of fever,
endometritis, wound, urinary tract and other infection.There is no advantage in using multiple doses compared
The document points out that failed intubation has a re-
with a single dose.Ampicillin and first generation
ported incidence of 1/249and is still an occasional
cephalosporins are equally effective.
cause of maternal The place of the laryngeal
Women having caesarean section should be offered
mask and the importance of a failed intubation drill
prophylactic antibiotics Á Á Á to reduce the risk of post-
operative infections, which occur in about 8% of
General anaesthesia for caesarean section should
include preoxygenation, cricoid pressure and rapidsequence induction to reduce the risk of aspiration[GPP]
Each maternity unit should have a drill for failed intu-
The reported incidence of pulmonary thromboembolismis 6 per 10 000 maternities but varies with maternal age,obesity and smoking.It is the leading direct cause of
Surgical techniques for caesarean section of
maternal death in the UKVarious interventions have
been explored for its prevention but the trials were toosmall to evaluate outcoIncreased risk is associated
with emergency versus elective caesarean section,
The authors remind us that the licensed dose of oxytocin
maternal age >35 years, weight >80 kg and medical
for caesarean section is 5 units by slow intravenous
complications. Recommended thromboprophylaxis in-
injection; problems associated with the use of larger bo-
cludes hydration, early mobilisation, graduated elastic
lus doses given rapidly are highliOne RCT
comparing different oxytocin infusion concentrations
(20 versus 160 units/L) showed no difference in the inci-
Women having caesarean section should be offered
dence of hypotension but the lower-concentration group
thromboprophylaxis because they are at increased
were more likely to need additional utertoEvi-
risk of thromboembolism. The chosen method of pro-
dence is divided about whether prostaglandins are as
phylaxis. should take into account risk of thrombo-
effective as oxytoOxytocin, however, has a
Oxytocin 5 units by slow intravenous injection should
be used at caesarean section to encourage contraction
Care of the baby born by caesarean section
of the uterus and to decrease blood loss. [C]Perhaps ill-advisedly, there is no mention of the need
The guidelines state that infants born by caesarean sec-
to follow this with an oxytocin infusion.
tion under general anaesthesia are at an increased risk of
International Journal of Obstetric Anesthesia
1-and 5-min Apgar scores <7 when compared with those
guidelines state that the postoperative care of a caesar-
born with regional anaesthesia, but most studies find that
ean section patient should meet the same standard of
only the one-minute score is affected.
care as that required for any postoperative patient.
An appropriately trained practitioner skilled in
After caesarean section, women should be observed
resuscitation of the newborn should be present at
on a one-to-one basis by a properly trained member
caesarean section performed under general anaes-
of staff until they have regained airway control and
thesia or where there is evidence of fetal compro-
cardiorespiratory stability and are able to communi-
After recovery from anaesthesia, observations (respi-
Care of the woman after caesarean section
ratory rate, heart rate, blood pressure, pain and seda-tion) should be continued every half hour for two
High dependency and intensive care admission
hours and hourly thereafter provided that the observa-tions are stable or satisfactory. If these observations
The incidence of severe morbidity among parturients has
are not stable, more frequent observations and medi-
been reported to be 12 per 1000 deliveries.A small
proportion of women (0.1–0.9%) develop complicationsof pregnancy that require admission to intensive
The NSCSA reported that 10% of women who had cae-sarean section required admission to a high dependency
unit; 3.5% of these women were transferred to intensivecare.shows the proportion of women who re-
Morphine is commonly used in countries other than the
quired admission to intensive care following caesarean
UK,where diamorphine is available and used with
section, according to the reason for caesarean section.
good effect.Both are effective but diamorphine
The indications for caesarean section that were most
has fewer and less severe side effBoth morphine
likely to lead to admission to intensive care accounted
and diamorphine may be given both epidurally and
for <20% of all caesarean sections. Maternal disease
intratand relative efficacy and side effects
produced the largest number of women. The recommen-
Women should be offered diamorphine (0.3–0.4 mg
Health professionals caring for women after caesar-
intrathecally) for intra- and postoperative analgesia
ean section should be aware that, although it is rare
because it reduces the need for supplemental analge-
for women to need intensive care following childbirth
sia after caesarean section. Epidural diamorphine
this occurs more frequently after caesarean section
(2.5–5.0 mg) is a suitable alternative. [A]
Patient controlled analgesia (PCA) and non-steroidal
Routine monitoring after caesarean section
Poor postoperative care is a recurring factor in maternal
In the absence of intrathecal or epidural opioid analge-
deaths.The national obstetric anaesthetic service
sia, opioid PCA may be used for postoperative analge-sia. There is little difference among the variousrecipes.
Admission to intensive therapy unit (ITU) according to
Rectal diclofenac administered immediately after
caesarean section is regularly found to reduce the need
Patient controlled analgesia using opioid analgesics
Providing there is no contraindication, non-steroidal
anti-inflammatory drugs should be offered after cae-
sarean section as an adjunct to other analgesics,
because they reduce the need for opioids. [A]
Data from The National Sentinel Caesarean Section Audit Report.
As an alternative to systemic analgesia, wound infiltra-
The odds ratio was calculated in relation to the proportion of women
tion and ilioinguinal nerve block have been found
with breech presentation who were admitted to ITU, but by extrapo-
equally effective in relieving pain after caesarean
lation it appears that this proportion was similar to that in the caesareansection population taken as a whole, which is lucky.
The National Institute of Clinical Excellence (NICE) guidelines for caesarean sections
and the use of regional anaesthesia and analgesia toimprove safety and quality of care. One might quibble
Early eating and drinking after caesarean section
with the view that spinal is safer than general anaes-
A systematic review of six RCTs comparing early with de-
thesia for the babythat ephedrine or phenylephrine
layed oral fluids and food after caesarean section found
may be “offered” indiscrimior that crystal-
that early eating and drinking were associated with re-
loid is effective to prevent maternal hypotensio
duced time to return of bowel sounds and reduced hospital
and with the omission of any mention of maternal
stay.There was no difference between the groups with
oxygen during regional anaesthesia or of oxytocin
respect to nausea and vomiting, abdominal distension,
time to bowel action, paralytic ileus or need for analgesia. Women who are recovering well and who do not
have complications Á Á Á can eat and drink when they
1. Thomas J, Paranjothy S., Royal College of Obstetricians and
Gynaecologists Clinical Effectiveness Support Unit. The National
Urinary catheter removal after caesarean section
Sentinel Caesarean Section Audit Report. London: RCOG Press,2001.
The best time to remove a urinary catheter and the value
2. Department of Health. Changing Childbirth. Report of the Expert
Maternity Group. Part 1. London: HMSO, 1993.
of routine indwelling catheterisation are currently uncer-
3. Audit Commission for Local Authorities and the NHS in England
tain.No difference has been detected in the inci-
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Onderzoeksgroep Ontwikkelingsstoornissen In de loop van 2005-2006 ondersteunde Sig een onderzoek in het UZ Gent. Het doel was na te gaan wat het effect is van Atomoxetine (Strattera ®) op het gedrag en een aantal cognitieve functies van kinderen met ADHD, kinderen met dyslexie, en kinderen met ADHD+dyslexie. Hierbij willen we u graag op de hoogte stellen van de belangrijkste resultaten. Opzet va
NORLEVO ® PATIENT INFORMATION LEAFLET Read all of this leaflet carefully before you take this medicine. This medicine is available without a doctor’s prescription, for you to treat a condition. Nevertheless you still need to use NORLEVO® carefully to get the best results from it. Keep this leaflet. You may need to read it again. Ask your pharmacist if you need more information o