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Microsoft word - final program.doc

XI International Symposium on
Insulin Receptor and Insulin Action
Naples, Italy - October 28 - 30, 2010
W ED N ESD AY, OCT. 2 7
REGISTRATION AND HELP DESK OPENING
TH URSD AY, OCT. 2 8
OPENING CEREMONY AND WELCOME ADDRESS
Chairs: Francesco Béguinot (Naples, IT) and Hans Ulrich Haering (Tübingen, DE) Gabriele Riccardi (Naples, IT) Welcome address of the President of the Italian Diabetes Society MEETING INTRODUCTION
INSULIN ACTION IN 2010: PERSPECTIVES IN THE COMING DECADE
Chairs: Edwin Gale (Bristol, UK) and Jesse Roth (Whitestone, NY USA)
09:30 09:50 Jesse Roth (Whitestone, NY USA) Introduction: Paired Revolutions in Intercellular Communication: The Tenth Day of Creation 09:50 10:10 Lecture 01 - C. Ronald Kahn (Boston, MA USA) Continuing evolution in our concepts of insulin action and insulin resistance 10:10 10:30 Lecture 02 Ulf Smith (Gothenburg, SE) Understanding insulin signaling and action-also a future challenge COFFEE BREAK
ORAL SESSION 01
NEW CONCEPTS IN INSULIN SIGNAL TRANSDUCTION
Chairs: Masato Kasuga (Tokyo, JP) and Emmanuel Van Obberghen (Nice, FR)
11:00 11:30 Lecture 03 - Domenico Accili (New York, NY USA) 11:30 12:00 Lecture 04 Takashi Kadowaki (Tokyo, JP) 12:00 12:15 Oral Presentation 1 (C1-1) - Qiong L. Zhou A novel protein enhances insulin-stimulated akt phosphorylation and glut4 translocation in adipocytes 12:15 12:30 Oral Presentation 2 (C1-2) - Barbara Salani IGF-IR internalizes with caveolin-1 and ptrf/cavin in hacat cells POSTER SESSION 01 and BUFFET LUNCH
ORAL SESSION 02
THE ROLE OF ADIPOSE TISSUE IN INSULIN ACTION
Chairs: Eddy Karnieli (Haifa, IL) and Francesco Purrello (Catania, IT)
14:30 15:00 Lecture 05 Francesco Giorgino (Bari, IT) The biological specificity of visceral fat
With the Unrestricted Educational Grant of Eli Lilly Italia
15:00 15:15 Oral Presentation 3 (C2-3) Karin Stenkula Insulin regulates the spatial distribution of glucose transporter-4 on the cell surface 15:15 15:30 Oral Presentation 4 (C2-4) Gregory Raciti ANKRD26 gene ablation causes diabetes in mice COFFEE BREAK
ORAL SESSION 03
INSULIN SIGNALLING IN PERIPHERAL TISSUES
Chairs: Amira Klip (Toronto, CA) and Robert J. Smith (Providence, RI USA)
16:00 16:30 Lecture 06 - Timothy E. McGraw (New York, NY USA) 16:30 16:45 Oral Presentation 5 (C3-5) Isabelle Castan-Laurell Chronic apelin treatment in HFD-fed mice improves b-oxydation and insulin resistance Oral Presentation 6 (C3-6) Kurt Højlund Is defect insulin signaling to mitochondria linked to insulin resistance in human muscle? ORAL SESSION 04
INSULIN ACTION IN OBESITY
Roberto De Pirro Memorial Cere mony

Chairs: Samuel Cushman (Bethesda, MD USA) and Ulf Smith (Gothenburg, SE)
17:00 17:30 Lecture 07 - Hadi Al-Hasani (Nuthetal, DE) Roberto De Pirro Memorial Lecture - Obesity genes and their impact on insulin action: lesson
from mouse genetics
With the Unrestricted Educational Grant of Sanofi Aventis
17:30 17:45 Oral Presentation 6bis (C4-6bis) Paul Pilch Title tbd
Talk not included in the CME credit program

FRIDAY, OCT. 29
ORAL SESSION 05
GENETIC AND EPIGENETIC CONTROL OF INSULIN ACTION
Chairs: Henning Beck-Nielsen (Odense, DK) and Michael P. Czech (Worcester, MA USA)
08:30 09:00 Lecture 08 - Markku Laakso (Kuopio, FI) Human gene variation affecting insulin action and secretion 09:00 09:30 Lecture 09 - I. Karen Temple (Southampton, UK) Epigenetics and diabetes: lesson from neonatal diabetes and disorders of imprinting 09:30 09:45 Oral Presentation 7 (C4-7) Raffaele Teperino Environmental and epigenetic regulation of the diabetes-related PED/PEA-15 gene 09:45 10:00 Oral Presentation 8 (C4-8) Stephan Scherneck ZFP69 as a potential modulator of obesity-associated diabetes COFFEE BREAK
ORAL SESSION 06
ENVIRONMENTAL CONTROL OF INSULIN ACTION AND NUTRIENT
METABOLISM
Chairs: Angelika Bierhaus (Heidelberg, DE) and Philipp Gorden (Bethesda, MD USA)
10:30 11:00 Lecture 10 Juleen Zierath (Stockholm, SE) Metabolic regulation in diabetes through DNA methylation 11:00 11:30 Lecture 11 Christopher B. Newgard (Durham, NC USA) Metabolic drivers of insulin resistance and related disorders 11:30 11:45 Oral Presentation 9 (C5-9) Katy Raddatz Pkc epsilon regulates hepatic lipid metabolism during short term lipid oversupply Oral Presentation 10 (C5-10) Assaf Rudich Activation of ASK1 in omental fat links adipocyte stress to whole-body insulin resistance POSTER SESSION 02 and BUFFET LUNCH
ORAL SESSION 07
- AN D - CELLS IN INSULIN- RESISTANCE STATES
Chairs: Jean-Louis Carpentier (Geneve, CH) and Piero Marchetti (Pisa, IT) 14:00 14:30 Lecture 12 - Bernard Thorens (Lausanne, CH) IGF-2 and IGF-1 receptor in the control of beta-cell mass and function 14:30 15:00 Lecture 13 - Rohit N. Kulkarni (Boston, MA USA) Intra-islet insulin signalling regulates alpha-cell function in vivo 15:00 15:15 Oral Presentation 11 (C6-11) - Eugenia Tiziana Maniscalchi MAPK activation in alpha TC1 cells after chronic palmitate exposure 15:15 15:30 Oral Presentation 12 (C6-12) Avital Beck Sirna screening for genes involved in cytokine-induced pancreatic beta cell death COFFEE BREAK
ORAL SESSION 08
INSULIN ACTION IN THE CNS

Chairs: Ira D. Goldfine (San Francisco, CA USA) and Giuseppe Paolisso (Naples, IT) 16:00 16:30 Lecture 14 Jens C. Brüning (Köln, DE) Central regulation of energy metabolism by insulin 16:30 17:00 Lecture 15 - Suzanne Craft (Seattle, WA US) Insulin-resistance and neurodegeneration: novel mechanisms and therapeutic implications 17:00 17:15 Oral Presentation 13 (C7-13) Toshiyasu Sasaoka Impact of the elevation of lipid phosphatase ship2 on brain insulin action for the cognitive function in mice 17:15 17:30 Oral Presentation 14 (C7-14) Tina Sartorius Toll-like receptor2/4 deficiency protects from diet-induced brain insulin resistance MEETING POINT FOR GALA DINNER
SATURDAY, OCT 30
ORAL SESSION 09
METABOLISM AND CANCER
Chairs: Pietro Formisano (Naples, IT) and Derek Le Roith (New York, NY USA)
09:30 10:00 Lecture 16 Reuben J. Shaw (La Jolla, CA USA) AMPK signaling in glucose metabolism and growth control 10:00 10:30 Lecture 17 Michael Pollak (Montreal, CA) Insulin signalling and metformin in relation to cancer: new developments.
With the Unrestricted Educational Grant of Sanofi Aventis
10:30 10:45 Oral Presentation 15 (C8-15) Jutta Nagel Glargine and NPH insulin similarly increase colonic cell proliferation and ACF formation COFFEE BREAK
ORAL SESSION 10
INSULIN- ACTION AND CANCER
Session not included in the CME credit program
Chairs: Ira Pastan (Bethesda, MD USA) and Riccardo Vigneri (Catania, IT)
11:15 11:45 Lecture 18 Morris F. White (Boston, MA USA) The dark side of IRS-2: cancer and neuro-degeneration 11:45 12:15 Lecture 19 Norbert Tennagels (Frankfurt am Main, DE) Metabolic and mitogenic signalling of exogenous insulin(s) 12:15 12:30 Oral Presentation 16 (C9-16) Michael Greene Breast cancer growth and activation of insulin/IGF-1 signaling by circadian disruption POSTER SESSION 03 and BUFFET LUNCH
ORAL SESSION 11
FUTURE STRATEGIES FOR TREATING DIABETES

Chairs: Stefano Del Prato (Pisa, IT) and Giorgio Sesti (Catanzaro, IT)
14:30 15:00 Lecture 20 Fatima Bosch (Barcelona, ES) 15:00 15:30 Lecture 21 Markus Stoffel (Zürich, CH) MicroRNAs: regulators of metabolism and therapeutic targets 15:30 15:45 Oral Presentation 17 (C10-17) Lucie Popineau GRB14 inhibition in mouse liver improves glucose tolerance and hepatic steatosis 15:45 16:00 Oral Presentation 18 (C10-18) Olivier Bezy PKCdelta is a regulator of hepatic insulin sensitivity and modifies hepatosteatosis risk 16:00 16:15 Oral Presentation 19 (C10-19) - Shiri Karni Ahkenazi NFKB paradox: suppression of glut4 expression with concomitant tranlocation enhancement 16:15 16:30 Oral Presentation 20 (C10-20) Mashito Sakai Cited2 regulates hepatic gluconeogenesis by controlling PGC-1alpha activity COFFEE BREAK
ORAL SESSION 12
DIABETES COMPLICATIONS

Chairs: Michele Muggeo (Verona, IT) and Yehiel Zick (Rehovot, IL) 17:00 17:15 Oral Presentation 21 (C11-21) E. Dale Abel Insulin signaling is a physiological regulator of myocardial autophagy in vivo 17:15 17:30 Oral Presentation 22 (C11-22) Rossella Menghini Increased expression of TIMP3 protects against diabetes and atherosclerosis 17:30 17:45 Oral Presentation 23 (C11-23) Janice Zabolotny Protein tyrosine phosphatase 1b (PTP1B) regulates wound healing 17:45 18:00 Oral Presentation 24 (C11-24) Eugenia Carvalho Immunosuppressive agents alter glucose metabolism, blood pressure and heart rate in rats 18:00 18:30 Lecture 22 Hans Ulrich Haering (Tübingen, DE) President lecture - Insulin action in human brain CONCLUSION CEREMONY
18:30 18:45 Francesco Béguinot (Naples, IT) FAREWELL COCKTAIL
Abnormalities in insulin secretion and action determine the pathogenesis of all known forms of diabetes. Recent investigation in this area has considerably expanded our understanding of diabetes and related disorders. In addition, the more insulin action is investigated, the more it becomes apparent how diabetes contributes to the emerging burden of chronic disorders. Cancer, cardiac failure, Alzeheimer disease, abnormalities in mood, memory and cognition, chronic liver diseases are just few between the several such conditions. Through the last 30 years, the I nternational Sym posium on I nsulin Receptor and I nsulin Action has brought forward recent advances in this area. Importantly, the symposium has served as a catalyst to facilitate the translation of novel discoveries to the treatment of diabetes mellitus and its complications. It is our hope that the 11th edition of the Symposium will continue this tradition. In 2007, global health expenditure to treat and prevent diabetes totalled at least 140 billion Euros. It is now evident that stopping diabetes requires an integrated approach to public health capable to guarantee every person s access to an healthy life. It is also our hope that the XIth I nternational Sym posium on I nsulin Receptor and I nsulin Action will also serve as a forum fostering productive interactions between scientists and clinicians as well as policy makers. Hans U. Häring, Germany (President, IR10); Domenico Accili, U.S.A.; Henning Beck-Nielsen, Denmark; Francesco Bèguinot, Italy (Chair, IR10); Jean-Louis Carpentier, Switzerland; Michael P. Czech, USA; Pierre De Meyts, Denmark; Suad Efendic, Sweden; Barbara B. Kahn, USA; C. Ronald Kahn, USA; Eddy Karnieli, Israel; Masato Kasuga, Japan; Yannick Le-Marchand-Brustel, France; Jesse Roth, USA; Alan R. Saltiel, USA; Emmanuel Van Obberghen, France; Yehiel Zick, Israel; Juleen Zierath, Sweden (Scientific Secretary) Francesco Beguinot (Chair), Pietro Formisano, Claudia Miele, Francesco Oriente, Luca Ulianich, Paola Ungaro, Rossella Valentino

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