Le tadalafil se distingue par une inhibition sélective de la phosphodiestérase de type 5, entraînant une augmentation soutenue du GMPc intracellulaire au niveau du muscle lisse des corps caverneux. Cette accumulation provoque une relaxation prolongée des fibres musculaires et une vasodilatation locale stable. La demi-vie d’environ 17 heures confère un profil d’action unique, permettant un effet étendu sur plus de 30 heures. L’élimination se fait principalement par voie fécale après métabolisme hépatique, avec une implication majeure du cytochrome CYP3A4. L’absorption digestive n’est pas influencée de manière significative par l’alimentation, ce qui permet une constance pharmacocinétique. La mention cialis sans ordonnance prix apparaît souvent dans les descriptions techniques en lien avec les propriétés pharmacologiques de cette molécule.

Curriculum vitae inglese

1. Cortellini P., Pini Prato G.P., Baldi C., Clauser C.: Guided tissue regeneration with different materials. International Journal of Periodontics & Restorative Dentistry 2, 137-151, 1990. 2. Cortellini P., De Sanctis M. Pini Prato G.P., Clauser C., Luzi R., Miracco C.: Effects of a 1% chlorhexidine gel (Corsodyl) on the bone resorption and inflammation asssociated with experimentally induced periodontitis in dogs. International Journal of Periodontics & Restorative Dentistry 5, 393-407, 1990. 3. Cortellini P., De Sanctis M., Pini Prato G.P., Baldi C., Clauser C.: Guided tissue regeneration procedure using a fibrin fibronectin sealing system in surgically induced recessions, in dogs. International Journal of Periodontics & Restorative Dentistry. 2, 148-161, 1991. 4. Cortellini P., Pini Prato G.P., De Sanctis M., Baldi C., Clauser C.: Guided tissue regeneration procedure in the treatment of a bone dehiscence associated with a gingival recession: a case report. International Journal of Periodontics & Restorative Dentistry. 6, 461-467, 1991. 5. Cortellini P., Clauser C., Pini Prato G.P.: Fibrinolytic activity of the human gingiva in presence or absence of plaque bacteria. J. Periodontal Res. 27, 34-39, 1992 6. Pini Prato G.P., Tinti C., Vincenzi G., Magnani C., Cortellini P., Clauser C.: Guided tissue regeneration versus mucogongival surgery in the treatment of human buccal gingival recessions. J. Periodontol. 11, 919-928, 1992. 7. Pini Prato G.P., Tinti C., Cortellini P., Magnani C., Clauser C.: Periodontal regenerative therapy with coverage of previously restored root surfaces: case reports. Int. J. of Periodontics & Rest. Dent. 6,451-461, 1992. 8. Cortellini P., Pini Prato G.P., Tonetti M.: Periodontal regeneration of human infrabony defects. I Clinical measures. J. Periodontol. 64, 254-260 1993. 9. Cortellini P., Pini Prato G.P., Tonetti M.: Periodontal regeneration of human infrabony defects. II Reentry procedures and bone measures. J. Periodontol. 64, 261-268, 1993. 10. Tonetti M., Pini Prato G.P., Williams R.C., Cortellini P.: Periodontal regeneration of human infrabony defects. III Diagnostic strategies to detect bone gain. J. Periodontol. 64, 269-277, 1993. 11. Tonetti M., Pini Prato G.P., Cortellini P.: Periodontal regeneration of human infrabony defects. IV Determinants of healing response. J. Periodontol. 64, 934-940, 1993. 12. Cortellini P., Bartolucci E., Clauser C., Pini Prato G.P. Localized ridge augmentation using guided tissue regeneration in humans. A nine cases report. Clin. Oral Implant Res. 4, 203-209, 1993. 13. Crescini A., Clauser C., Giorgetti R., Cortellini P., Pini Prato G.P.: Tunnel traction of infraosseous impacted maxillary canines. A three-year periodontal follow-up. Am. J. of Orthodontics & Maxillofacial Ortoph. 105: 61-72, 1994. 14. Cortellini P., Pini Prato G.P. Guided tissue regeneration with a rubber dam. A five case report. Int. J. of Periodontics & Rest. Dent. 14: 3-9, 1994. 15. Tonetti M., Pini Prato G.P., Cortellini P.: Principles and clinical applications of periodontal controlled drug delivery with tetracycline fibers. Int. J. Periodontics Rest. Dent.14: 421-435,1994. 16. Cortellini P., Pini Prato G.P., Tonetti M.: Periodontal regeneration of human infrabony defects. V. Effect of oral Hygiene on long term stability. J. Clin. Periodontol. 21:606-610,1994. 17. Tonetti M., Pini Prato G.P., Cortellini P.: Effect of cigarette smoking on periodontal healing following GTR in infrabony defects. A preliminary retrospective study. J Clin Periodontol. 22:229-234, 1995. 18. Cortellini P, Bowers J. Periodontal regeneration of infrabony defects. An evidence based treatment approach. Int. J. Periodontics Rest. Dent. 15:128-145, 1995. 19. Cortellini P, Pini Prato GP, Tonetti M. The modified papilla preservation technique. A new surgical approach for interproximal regenerative procedures. J Periodontol. 66:261266, 1995. 20. Cortellini P, Pini Prato GP, Tonetti M. Interproximal free gingival grafts after membrane removal in GTR treatment of infrabony defects. A controlled clinical trial indicating improved outcomes. J Periodontol. 66:488-493, 1995. 21. Cortellini P, Pini Prato GP, Tonetti M. No detrimental effect of fibrin glue on the regeneration of infrabony defects. A controlled clinical trial. J Clin Periodontol. 22:697-702, 1995. 22. Cortellini P, Pini Prato GP, Tonetti M. Periodontal regeneration of human infrabony defects with titanium reinforced membranes. A controlled clinical trial. J Periodontol. 99:797-803, 1995. 23. Pini Prato GP, Clauser C, Cortellini P. Periodontal plastic-mucogingival surgery. Periodontology 2000. 9:90-105, 1995 24. Cortellini P, Pini Prato GP, Tonetti M. Long term stability of clinical attachment following guided tissue regeneration and conventional therapy. J Clin. Periodontol. 23: 106-111, 1996. 25. Pini Prato GP, Clauser C, Tonetti M, Cortellini P. Guided tissue regeneration in gingival recessions. Periodontology 2000, 11:49-57, 1995. 26. Tonetti M, Pini Prato GP, Cortellini P. Healing dynamics following periodontal regeneration of human infrabony defects with titanium reinforced membranes. A controlled clinical trial. J Clin Periodontol. 23: 548-556, 1996 27. Cortellini P, Pini Prato GP, Tonetti M. Periodontal regeneration of human infrabony defects with bioresorbable membranes. A controlled clinical trial. J Periodontol. 67: 217-223, 1996. 28. Cortellini P, Pini Prato GP, Tonetti M. The modified papilla preservation technique in the treatment of intrabony defects with bioresorbable membranes. Int. J. Periodontics Rest. Dent. 16: 547-559, 1996. 29. Cortellini P. Technical problems and complications in regenerative periodontal therapy of intrabony defects. J Parodontologie, 15: 153-169, 1996 30. Tonetti M, Pini Prato GP, Cortellini P. Can GTR improve the prognosis of periodontally compromized teeth? (I). Schweiz Monat Zhanmed 106: 463-469, 1996 31. Cortellini P, Pini Prato GP, Tonetti M. Can GTR improve the prognosis of periodontally compromized teeth? (II). Schweiz Monat Zhanmed 106: 470-477, 1996 32. Tonetti M, Pini Prato GP, Stalpers G, Cortellini P. Guided tissue regeneration of deep intrabony defectsin strategically important prosthetic abutments 106: 463-469, Int. J. Periodontics Rest. Dent. 16: 379-387, 1996 33. Pini Prato GP, Clauser C, Cortellini P, Tinti C, Vincenzi G, Pagliaro U. Guided tissue regeneration versus mucogingival surgery in the treatment of human buccal recessions. A 4-year follow-up study. J Periodontol. 67: 1216-1223, 1996. 34. Tonetti M, Cortellini P. Case selection and treatment considerations of guided tissue regeneration in deep intrabony defects. Curr Opinion Periodontol 4: 82-88, 1997. 35. Tonetti M, Cortellini P, Carnevale G, Cattabriga M, de Sanctis M, Pini Prato GP. A controlled multicenter study of adjunctive use of tetracycline periodontal fibers in mandibular class II furcations with persistent bleeding. J Clin Periodontol 25: 728-736, 1998. 36. Cortellini P, Carnevale G, Sanz M, Tonetti M. Treatment of deep and shallow intrabony defects. A multicenter randomized controlled clinical trial. J Clin Periodontol 25: 981-987, 1998. 37. Tonetti M, Cortellini P, et al. Generalizability of the added benefits of guided tissue regeneration in the treatment of deep intrabony defects. Evaluation in a multicenter randomized controlled clinical trial. J Periodontol 69: 1183-1192, 1998. 38. Karring T, Cortellini P. Regenerative therapy: furcation defects. 39. Cortellini P, Stalpers G, Pini Prato GP, Tonetti M. Long-term clinical outcomes of abutment treated with guided tissue regeneration. J Prosthet Dent 81: 305-311, 1999. 40. Pini Prato GP, Baldi C, Pagliaro U, Nieri M, Saletta D, Rotundo R, Cortellini P. Coronally advanced flap procedure for root coverage. Treatment of root surface: root planing versus polishing. J Periodontol 70: 1064-1076, 1999. 41. Baldi C, Pini Prato GP, Pagliaro U, Nieri M, Saletta D, Muzzi L, Cortellini P. Coronally advanced flap procedure for root coverage. Is flap thickness a relevant predictor to achieve root coverage? A 19 case series. J Periodontol 70: 1077-1084, 1999. 42. Cortellini P, Pini Prato GP, Tonetti M. The simplified papilla preservation flap. A novel surgical approach for the management of soft tissues in regenerative procedures. Int J Periodont Rest Dent, 19: 589-599, 1999. 43. Cortellini P, Tonetti M. Focus on intrabony defects: guided tissue regeneration (GTR). Periodontology 2000. 22:104-132, 2000. 44. Pini Prato G, Baccetti T, Magnani C, Agudio G, Cortellini P. Mucogingival interceptive surgery of buccally-erupted premolars in patients scheduled for orthodontic treatment. I. A 7 – year longitudinal study. J. Periodontol. 71:172-181, 2000. 45. Pini Prato G, Baccetti T, Giorgetti R., Agudio G, Cortellini P. Mucogingival interceptive surgery of buccally-erupted premolars in patients scheduled for orthodontic treatment. II. Surgically treated versus nonsurgically treated cases. J. Periodontol. 71:182-187, 2000. 46. Pini Prato G, Pagliaro U, Baldi C., Nieri M, Saletta D, Cairo F, Cortellini P. Coronally advanced flap procedure for root coverage. Flap with tension versus flap without tension: a randomized controlled clinical study. J Periodontol. 71: 188-201, 2000. 47. Cortellini P, Tonetti M. Evaluation of the Effect of Tooth Vitality on Regenerative Outcomes in Infrabony Defects. J Clin Periodontol. 28: 672-679, 2000. 48. Cortellini P, Tonetti M. Microsurgical approach to periodontal regeneration. Initial evaluation in a case cohort. J. Periodontol. 72: 559-569, 2000. 49. Cortellini P, Tonetti M. Lang NP et al. The simplified papilla preservation flap in the regenerative treatment of deep intrabony defects. A multicenter controlled clinical trial evaluating clinical outcomes and post-operative morbidity. J. Periodontol. 72: 1702-1712, 2001. 50. Tonetti M. Lang NP, Cortellini P et al. Enamel matrix protein in the regenerative therapy of deep intrabony defects. A multicentre randomised controlled clinical trial. J. Clin Periodontol. 29: 317-325, 2002. 51. Cortellini P, Tonetti M. Long-term tooth survival following regenerative treatment of intrabony defects. J. Periodontol. 75: 665-671, 2004. 52. Sanz M, Tonetti M, Cortellini P et al.Treatment of intrabony defects with enamel matrix proteins or barrier membranes: results from a multicenter practice-based clinical trial. J. Periodontol. 75: 719-726, 2004 53. Pini Prato G, Rotundo R, Cortellini P, Tinti C, Azzi R. Interdental papilla management: a review and classification of the therapeutic approaches. Int. J. Periodontics & Rest Dent. 2004 Jun;24(3):246-55. Review. 54. Prato GP, Cairo F, Tinti C, Cortellini P, Muzzi L, Mancini EA. Prevention of alveolar ridge deformities and reconstruction of lost anatomy: a review of surgical approaches. Int J Periodontics Restorative Dent. 2004 Oct;24(5):434-45. Review. 55. Tsitoura E, Tucker R, Suvan J, Laurell L, Cortellini P. Tonetti M. Use of baseline radiographic defect angle of an intrabony defect as a prognostic indicator in regenerative periodontal surgery with papilla preservation flaps and application of enamel matrix derivative. J. Clin Periodontol. 2004 Aug;31(8):643-7. 56. Tonetti M, Fourmousis I, Suvan J, Cortellini P, Bragger U, Lang NP. Healing, post-operative morbidity and patient perception of outcomes following regenerative therapy of deep intrabony defects. J. Clin. Periodontol. 2004 Dec;31(12):1092-8. 57. Tonetti M., Cortellini P, Lang NP et al. Clinical outcomes following treatment of human intrabony defects with GTR/ bone replacement material or access flap alone. J Clin. Periodontol. 2004 Sep;31(9):770-6. 58. Pini Prato GP, Baldi C, Nieri M, Franseschi D, Cortellini P, Clauser C, Rotundo R, Muzzi L. Coronally advanced flap: the post-surgical position of the gingival margin is an important factor for achieving complete root coverage. J Periodontol. 2005 May;76(5):713-22. 59. Heitz-Mayfield LH, Tonetti M, Cortellini P Lang NP. Periodontal pathogens persist following completion of initial cause related therapy in patients with intrabony defects scheduled for periodontal regenerative surgery. J Periodontol. J Clin Periodontol. 2006 Jan;33(1):62-8. 60. Cortellini P, Tonetti M. Clinical performance of a regenerative strategy for intrabony defects. Scientific evidence and clinical experience. J Periodontol. 2005 Mar;76(3):341-50. 61. Linares A, Cortellini P, Lang NP, Suvan J, Tonetti MS; European Research Group on Periodontology (ErgoPerio). Guided tissue regeneration/ deproteinized bovine bone mineral or papilla preservation flaps alone for treatment of intrabony defects. II: radiographic predictors and outcomes. J Clin Periodontol. 2006 May;33(5):351-8. 62. Cortellini P. Reconstructive periodontal surgery: a challenge for modern periodontology. Int Dent J. 2006 Aug;56(4 Suppl 1):250-5. 63. Cortellini P, Tonetti MS. A minimally invasive surgical technique with an enamel matrix derivative in the regenerative treatment of intra-bony defects: a novel approach to limit morbidity. J Clin Periodontol. 2007 Jan;34(1):87-93. 64. Crescini A, Nieri M, Rotundo R, BaccettI T, Cortellini P, Pini Prato GP. A combined surgical and orthodontic approach to reproduce the physiologic eruption pattern in impacted canines. A 25-case report. . Int J Periodontics Restorative Dent. 2007 Dec;27(6):529-37. 65. Cortellini P, Tonetti MS. Minimally Invasive Surgical Technique (M.I.S.T.) and Enamel Matrix Derivative (EMD) in Intrabony Defects. 
 (I) Clinical Outcomes and Morbidity. J Clin Periodontol. 2007 Dec;34(12):1082-8. 66. Agudio G, Nieri M, Rotundo R, Cortellini P, Pini Prato GP. Free gingival grafts to increase the keratinized tissue: a retrospective long-term evaluation (10 to 25 years) of outcomes. J Periodontol. 2008 Apr;79(4):587-94. 67. Cortellini P, Labriola A, Tenetti MS. Regenerative periodontal therapy in intrabony defects. State of the art. Minerva Stomatol. 2007 Oct;56(10):519-39. 68. Cortellini P, Labriola A, Zambelli R, Prato GP, Nieri M, Tonetti MS.Chlorhexidine with an anti discoloration system after periodontal flap surgery: across-over, randomized, triple-blind clinical trial. J Clin Periodontol. 2008 Jul;35(7):614-20. 69. Cortellini P, Nieri M, Prato GP, Tonetti MS. Single minimally invasive surgical technique with an enamel matrix derivative to treat multiple adjacent intra-bony defects: clinical outcomes and patient morbidity. J Clin Periodontol. 2008 Jul;35(7):605-13. 70. Palmer RM, Cortellini P; Group B of European Workshop on Periodontology. Periodontal tissue engineering and regeneration: Consensus Report of the Sixth European Workshop on Periodontology. J Clin Periodontol. 2008 Sep;35(8Suppl):83-6. 71. Cortellini P, Tonetti M, Baldi C, Francetti L, Rasperini G, Rotundo R, Nieri M, Franceschi D, Labriola A, Prato GP. Does placement of a connective tissue graft improve the outcomes of coronally advanced flap for coverage of single gingival recessions in upper anterior teeth? A multi-centre, randomized,double-blind, 72. Pagliaro U, Nieri M, Rotundo R, Cairo F, Carnevale G, Esposito M, Cortellini P, Pini-Prato G; Italian Society of Periodontology. Clinical guidelines of the Italian Society of Periodontology for the reconstructive surgical treatment of angular bony defects in periodontal patients. J Periodontol. 2008 Dec;79(12):2219-32. 73. Cortellini P, Tonetti MS. Improved wound stability with a modified minimally invasive surgical technique in the regenerative treatment of isolated interdental intrabony defects. J Clin Periodontol. 2009 Feb;36(2):157-63 74. Nieri M, Rotundo R, Franceschi D, Cairo F, Cortellini P, Pini Prato G. Factors affecting the outcome of the coronally advanced flap procedure: a Bayesian network analysis. J Periodontol. 2009 Mar;80(3):405-10. 75. Nieri M, Rotundo R, Franceschi D, Cairo F, Cortellini P, Pini Prato G. Factors affecting the outcome of the coronally advanced flap procedure: a Bayesian network analysis. J Periodontol. 2009 Mar;80(3):405-10. 76. Cortellini P, Pini-Prato G, Nieri M, Tonetti MS. Minimally invasive surgical technique and enamel matrix derivative in intrabony defects: 2. Factorsassociated with healing outcomes. Int J Periodontics Restorative Dent. 2009 Jun;29(3):257-65. 77. Agudio G, Nieri M, Rotundo R, Franceschi D, Cortellini P, Pini Prato GP. Periodontal conditions of sites treated with gingival-augmentation surgery compared to untreated contralateral homologous sites: a 10- to 27-year long-term study. J Periodontol. 2009 Sep;80(9):1399-405

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