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Digital Infrared Thermal Imaging (DITI) research
Here is a selection of the growing body of research supporting the use of DITI for early
diagnosis of abnormalities and monitoring of healing. Here is just a small sample: Gautherie, M., et al. (1983). Thermobiological assessment of benign and malignant
breast diseases. American Journal of Obstetrics & Gynecology, (8)147, pp.861-869.
This study analysed the survival rates of 106 patients in whom the diagnosis of breast
cancer was established as a result of the follow-up of thermographic abnormalities found
on the initial examination when the breasts were apparently healthy (negative physical and
mammographic findings). A 61% increase in survival was noted in the patients who were
followed-up due to initial thermographic abnormalities. The authors summarised the study
by stating that "the findings clearly establish that the early identification of women at high
risk of breast cancer based on the objective thermal assessment of breast health results in
a dramatic survival benefit."
Gautherie, M. & Gros, C.M. (1980). Breast thermography and cancer risk prediction.
Cancer, 45, pp. 51-56.
Thermography is a useful predictor of risk factor for cancer and as an assessment tool for
rapidly growing tumours. Wladisalw, V. E. et al. (1989). Screening thermography of chronic back pain patients
with negative neuromusculoskeletal findings. Thermology, 3, pp. 125-126.
This blind study indicated that thermograph imaging is effective at detecting
Varju, G. et al. (2004). Assessment of hand osteoarthritis: correlation between
thermographic and radiographic methods. Rheumatology, 43(7), pp.915-9.
Thermographic scanning was found to be highly reliable at monitoring changes in
osteoarthritis of the hand. Heyes, G.J. & Mill, A.J. (2004).The neoplastic transformation potential of
mammography X rays and atomic bomb spectrum radiation. Radiation Research,
162, pp. 120-7.
This study suggests that the risks associated with mammography screening may be
approximately five times higher than previously assumed and that the risk-benefit
relationship of mammography exposures may need to be re-examined. Parisky, Y.R. et al. (2003). Efficacy of computerised infrared imaging analysis to
evaluate mammographyically suspicious lesions. American Journal of
Roentgenology, 180, pp.263-269.
In January 2003, Parisky and colleagues published their findings in 875 biopsied lesions
where thermography had an over 95% predictive value and concluded that infrared
imaging was a safe non-invasive procedure that would be a valuable adjunct to
mammography in determining whether a lesion was benign or malignant. Cavalierie, E. et al. (2000) Estrogens as endogenous genotoxic agents – DNA
adducts and mutations. Journal of the National Cancer Institute Monographs, 27,
Estrogens induce tumors in laboratory animals and have been associated with breast and
uterine cancers in humans. In relation to the role of estrogens in the induction of cancer,
we examine formation of DNA adducts by reactive electrophilic estrogen metabolites,
formation of reactive oxygen species by estrogens and the resulting indirect DNA damage
by these oxidants, and, finally, genomic and gene mutations induced by estrogens.
Quinone intermediates derived by oxidation of the catechol estrogens 4-hydroxyestradiol or
4-hydroxyestrone may react with purine bases of DNA to form depurinating adducts that
generate highly mutagenic apurinic sites.
In contrast, quinones of 2-hydroxylated estrogens produce less harmful, stable DNA
adducts. The catechol estrogen metabolites may also generate potentially mutagenic
oxygen radicals by metabolic redox cycling or other mechanisms. Several types of indirect
DNA damage are caused by estrogen-induced oxidants, such as oxidized DNA bases,
DNA strand breakage, and adduct formation by reactive aldehydes derived from lipid
hydroperoxides. Estradiol and the synthetic estrogen diethylstilbestrol also induce
numerical and structural chromosomal aberrations and several types of gene mutations in
cells in culture and in vivo
. In conclusion, estrogens, including the natural hormones
estradiol and estrone, must be considered genotoxic carcinogens on the basis of the
evidence outlined in this chapter. http://jncimono.oxfordjournals.org/cgi/content/abstract/2000/27/75 Keyserlingk. J.R et al. (1998). Infrared imaging of the breast: initial reappraisal using
high-resolution digital technology in 100 successive case of stage I and stage II
breast cancer. The Breast Journal, 4(4).
There is a general consensus that earlier detection of breast cancer should result in
improved survival. Current breast imaging relies primarily on mammography. Despite
better equipment and regulation, variability in interpretation and tisuue density still affect
acuragy. A number of adjuvant imaging techniques are currently being used, including
doppler ultrasound and gadolinium-enhanced MRI, which can detect cancer-induced
neovascularity. In order to assess the potential contribution of currently available high-
resolution digital infrared technology capable of recognizing minute regional vascular flow
related temperature variation, we retrospectively reviewed the relative ability of our
preoperative clinical exam, mammography, and infrared imaging to detect 100 new cases
of ductal carcinoma in situ, stage I and II breast cancer.
While the false-negative rate of infrared imaging was 17%, at least one abnormal infrared
sign was detected in the remaining 83 cases, including 10 of the 15 patients, a slightly
younger cohort, who had nonspecific mammograms. The 85% sensitivity rate of
mamography alone thus increased to 95% when combining both imaging modalities.
Access to infrared information was also pertinent when confronted with the relatively
frequent contributory but equivocal clinical exam (34%) and mammography (19%). The
average size of those tumors undetected by mammography or infrared mamography was
1.66 cm and 1.28 cm, respectively, while the false-positive rate of infrared imaging in
concurrent series of 100 successive benign open breast biopsies was 19%. Our initial
experience would suggest that, when done concomitantly with clinical exam and
mammography, high-resolution digital infrared imaging can provide additional safe,
practical, and objective information. Further evaluation, preferably in controlled prospective
multicenter trials, would provide valuable data. See the full report here:
Hobbins, W. & Amalu, A. Beating breast cancer.
For a very useful article on using Digitial Infrared Thermal Imaging for the early detection
and monitoring of breast cancer see this excellent article available at http://www.breastthermography.com/articles/beating-breast-cancer.doc
R E I N E S P R O G E S T E R O N und G E S T A G E N E Univ. Prof. Dr. Doris M. Gruber und Univ. Prof. DDr. Johannes C. Huber Universitätsklinik für Frauenheilkunde Abteilung für Gynäkologische Endokrinologie und Reproduktionsmedizin Währinger Gürtel 18 –20 A-1090 Wien email: firstname.lastname@example.org www.frauenaerztin-gruber.at Ordination Wiedner Hauptstraße 95/6 A-1050
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